Apomorphine sublingual as primary or secondary treatment for erectile dysfunction in patients with spinal cord injury

BJU International

Volumn 93, Issue 1, 2004, Pages 100-104

  Strebel, R T ^a,b   Reitz, A ^a   Tenti, G ^a,b   Curt, A ^a   Hauri, D ^b   Schurch, B ^a  

^a BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Apomorphine; Dopamine D2; Erectile dysfunction; Receptors; Spinal cord injury

Indexed keywords

APOMORPHINE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ERECTILE DYSFUNCTION; EVALUATION; EVOKED SOMATOSENSORY RESPONSE; FATIGUE; HEADACHE; HUMAN; MALE; NAUSEA; NEUROPHYSIOLOGY; PRIORITY JOURNAL; PUDENDAL NERVE; QUESTIONNAIRE; SIDE EFFECT; SPINAL CORD INJURY; SYMPATHETIC TONE; VERTIGO; VISUAL IMPAIRMENT;

ADMINISTRATION, SUBLINGUAL; ADULT; APOMORPHINE; DOPAMINE AGONISTS; ELECTROPHYSIOLOGY; HUMANS; IMPOTENCE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SPINAL CORD INJURIES; TREATMENT OUTCOME; URODYNAMICS;

EID: 1642538373     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2004.04565.x     Document Type: Article

References (25)

1. Althof SE, Levine SB. Clinical approach to the sexuality of patients with spinal cord injury. Urol Clin North Am 1993; 20: 527-34
2. Giuliano F, Hulting C, El Masry WS et al. Randomized trial of sildenafil for the treatment of erectile dysfunction in spinal cord injury. Sildenafil Study Group. Ann Neurol 1999; 46: 15-21
3. Schmid DM, Schurch B, Hauri D. Sildenafil in the treatment of sexual dysfunction in spinal cord injured male patients. Eur Urol 2000; 38: 184-93
4. Sanchez-Ramos A, Vidal J, Jauregui ML et al. Efficacy, safety and predictive factors of therapeutic success with sildenafil for erectile dysfunction in patients with different spinal cord injuries. Spinal Cord 2001; 39: 637-43
5. Derry F, Hulting C, Seftel AD, Sipski ML. Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review. Urology 2002; 60 (Suppl. 2): 49-57
6. Melis MR, Argiolas A, Gessa GL. Apomorphine-induced penile erection and yawning: site of action in brain. Brain Res 1987; 415: 98-104
7. Chen KK, Chan JY, Chang LS. Dopaminergic neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat. J Urol 1999; 162: 237-42
8. Stief C, Padley RJ, Perdok RJ, Sleep DJ. Cross-study review of the clinical efficacy of apomorphine SL 2 and 3 mg: Pooled data from three placebo-controlled, fixed-dose crossover studies. Eur Urol 2002; Suppl. 1: 12-20
9. Dula E, Bukofzer S, Perdok R, George M and the Apomorphine SL Study Group. Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction. Eur Urol 2001; 39: 558-3
10. Bukofzer S, Livesey N. Safety and tolerability of apomorphine SL (Uprima). Int J Impot Res 2001; 13 (Suppl. 3): S40-4
11. Sachs BD. Placing erection in context: the reflexogenic-psychogenic dichotomy reconsidered. Neurosci Biobehav Rev 1995; 19: 211-24
12. Giuliano F, Allard J, Rampin O et al. Spinal proerectile effect of apomorphine in the anesthetized rat. Int J Impot Res 2001; 13: 110-5
13. Giuliano F, Allard J, Rampin O et al. Proerectile effect of systemic apomorphine: existence of a spinal site of action. J Urol 2002; 167: 402-6
14. Maynard FM Jr, Bracken MB, Creasey G et al. International standards for neurological and functional classification of spinal cord injury. American Spinal Injury Association. Spinal Cord 1997; 35: 266-74
15. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-30
16. Opsomer RJ, Guerit JM, Wese FX, Van Cangh PJ. Pudendal cortical somatosensory evoked potentials. J Urol 1986; 135: 1216-8
17. Courtois FJ, Gonnaud PM, Charvier KH, Leriche A, Raymond DP. Sympathetic skin responses and psychogenic erections in spinal cord injured men. Spinal Cord 1998; 36: 125-31
18. Schafer W, Abrams P, Liao L et al. Good urodynamic practices, uroflowmetry, filling cystometry, and pressure-flow studies. Neurourol Urodyn 2002; 21: 261-74
19. Bors E, Cormarr AE. Neurological Urology. Basel: Karger, 1971
20. Courtois FJ, Charvier KF, Leriche A, Raymond DP. Sexual function in spinal cord injury men. I. Assessing sexual capability. Paraplegia 1993; 31: 771-84
21. Hackett GI. What do patients expect from erectile dysfunction therapy? Eur Urol 2002; Suppl. 1: 4-11
22. Montorsi F. The role of apomorphine in the treatment of erectile dysfunction. Eur Urol 2002; Suppl. 1: 4-11
23. Hatzichristou D, Saenz de Tejada I, Sleep DJ, Perdok R. Time to erection with Uprima® (apomorphine SL) 2 and 3 mg in men with erectile dysfunction (ED). Int J Impot Res 2002; 13 (Suppl. 4): S50
24. Ralph DJ, Sleep DJ, Perdok RJ, Padley RJ. Adverse events and patient tolerability of Apomorphine SL 2 and 3 mg: A cross-study analysis of phase II and III studies. Eur Urol 2002; Suppl. 1: 21-7
25. Bukofzer S, Livesey N. Safety and tolerability of apomorphine SL (Uprima®). Int J Impot Res 2001; 13 (Suppl. 3): S40-4