Randomized trial of sildenafil for the treatment of erectile dysfunction in spinal cord injury

Annals of Neurology

Volumn 46, Issue 1, 1999, Pages 15-21

  Giuliano, François ^a   Hultling, Claes ^b   El Masry, Wagih S ^c   Smith, Mike D ^d   Osterloh, Ian H ^d   Orr, Malcolm ^d   Maytom, Murray ^e  

^a BICÊTRE HOSPITAL   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Centre for Spinal Studies   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^e PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERANCE; DRUG WITHDRAWAL; ERECTILE DYSFUNCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT SATISFACTION; PENIS PROSTHESIS; PRIORITY JOURNAL; QUALITY OF LIFE; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; SPINAL CORD INJURY; STATISTICAL ANALYSIS; SYMPATHETIC INNERVATION;

ADMINISTRATION, ORAL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMANS; IMPOTENCE; MALE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; SPINAL CORD INJURIES;

EID: 0033048386     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(199907)46:1<15::AID-ANA5>3.0.CO;2-U     Document Type: Article

References (30)

1. Smith EM, Bodner DR. Sexual dysfunction after spinal cord injury. Urol Clin North Am 1993;20:535-542
2. Gutierrez PA, Young RR, Vulpe M. Spinal cord injury: an overview. Urol Clin North Am 1993;20:373-382
3. Levi R, Hultling C, Seiger A. The Stockholm Spinal Cord Injury Study: 2. Associations between clinical patient characteristics and post-acute medical problems. Paraplegia 1995;33:585-594
4. NIH Consensus Development Panel on Impotence. Impotence. JAMA 1992;270:83-90
5. Bodner DR, Lindan R, Leffler E, et al. The application of intracavernous injection of vasoactive medications for erection in men with spinal cord injury. J Urol 1987;138:310-311
6. Bodner DR, Leffler B, Frost F. The role of intracavernous injection of vasoactive medication for the restoration of erection in spinal cord injured males: a three year follow-up. Paraplegia 1992;30:118-120
7. Heller L, Keren O, Aloni R, Davidoff G. An open trial of vacuum penile tumescence: constriction therapy for neurological impotence. Paraplegia 1992;30:550-553
8. Watanabe T, Chancellor MB, Rivas DA, et al. Epidemiology of current treatment for sexual dysfunction in spinal cord injured men in the USA model spinal cord injury centers. J Spinal Cord Med 1996;19:186-189
9. Collins KP, Hackler RH. Complications of penile prostheses in the spinal cord injury population. J Urol 1988;140:984-985
10. Kimoto Y, Iwatsubo E. Penile prostheses for the management of the neuropathic bladder and sexual dysfunction in spinal cord injury patients: long term follow up. Paraplegia 1994;32: 336-339
11. Derry FA, Dinsmore WW, Fraser M, et al. Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury. Neurology 1999;51:1629-1633
12. Giuliano FA, Rampin O, Benoit G, Jardin A. Neural control of penile erection. Urol Clin North Am 1995;22:747-766
13. Giuliano F, Bernabé J, Brown K, et al. Erectile response to hypothalamic stimulation in rats: role of peripheral nerves. Am J Physiol 1997;273:R1990-R1997
14. Sjostrand NO, Klinge E. Principal mechanisms controlling penile retraction and protrusion in rabbits. Acta Physiol Scand 1979;106:199-214
15. Courtois FJ, Charvier KF, Leriche A, Raymond DP. Sexual function in spinal cord injury men. I. Assessing sexual capability. Paraplegia 1993;31:771-784
16. Schmidt MH, Schmidt HS. The ischiocavernosus and bulbospongiosus muscles in mammalian penile rigidity. Sleep 1993; 16:171-183
17. Rampin O, Bernabé J, Giuliano F. Spinal control of penile erection. World J Urol 1997;15:2-13
18. Saenz de Tejada I, Moroukian P, Tessier J, et al. Trabecular smooth muscle modulates the capacitor function of the penis: studies on a rabbit model. Am J Physiol 1991;260:H1590-H1595
19. Andersson K-E, Wagner G. Physiology of penile erection Physiol Rev 1995;75:191-236
20. Burnett AL. Nitric oxide in the penis: physiology and pathology. J Urol 1997;157:320-324
21. Boolell M, Allen MJ, Ballard SA, et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 1996;8:47-52
22. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol 1996;78:257-261
23. Goldstein I, Lue TF, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338: 1397-1404
24. Ditunno JF Jr, Young W, Donovan WH, Creasey G. The international standards booklet for neurological and functional classification of spinal cord injury. Paraplegia 1994;32:70-80
25. Rosen RC, Riley A, Wagner G, et al. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-830
26. Conte MR. Development and use of self-report techniques for assessing sexual function: a review and critique. Arch Sex Behav 1983;12:555-576
27. Andersen BL, Broffitt B. Is there a reliable and valid self-report measure of sexual behavior? Arch Sex Behav 1988;17:509-525
28. Biering-Sørensen F, Sønksen J. Penile erection in men with spinal cord or cauda equina lesions. Semin Neurol 1992;12:98-105
29. Chapelle PA, Durand J, Lacert P. Penile erection following complete spinal injury in man. Br J Urol 1980;52:216-219
30. Comarr AE. Sexual function among patients with spinal cord injury. Urol Int 1970;25:134-168