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Volumn 122, Issue 10, 2000, Pages 2401-2402

Intramolecular catalysis of the cis-trans isomerization of proline peptide bonds in cyclic disulfide-containing peptides [16]

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; PEPTIDE; PROLINE;

EID: 0034653635     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja993901k     Document Type: Letter
Times cited : (27)

References (23)
  • 12
    • 46549094371 scopus 로고
    • trans|) and t is a variable delay during which transfer of magnetization occurs by interchange between the cis and trans isomers. The inversion-transfer method used here is described in the following: Robinson. G.; Kuchel, P. W.; Chapman, B. E.; Doddrell, D. M.; Irving, M. G. J. Magn. Reson. 1985, 63, 314-319.
    • (1985) J. Magn. Reson. , vol.63 , pp. 314-319
    • Robinson, G.1    Kuchel, P.W.2    Chapman, B.E.3    Doddrell, D.M.4    Irving, M.G.5
  • 13
    • 0343547818 scopus 로고
    • Rate constants were obtained from the inversion-transfer data by methods described in the following: Mariappan, S. V. S.; Rabenstein, D. L. J. Magn. Reson. 1992, 100, 13830-13837.
    • (1992) J. Magn. Reson. , vol.100 , pp. 13830-13837
    • Mariappan, S.V.S.1    Rabenstein, D.L.2
  • 15
    • 0343111947 scopus 로고    scopus 로고
    • note
    • 3
  • 17
    • 0343547819 scopus 로고    scopus 로고
    • note
    • The molecular mechanics simulations show that 1b and 2b interconvert among an ensemble of random conformations.
  • 18
    • 0343547816 scopus 로고    scopus 로고
    • note
    • The Monte Carlo molecular mechanics simulations were performed using Macromodel V6.5 and the OPLS force field. A 10 000 structure conformational search was performed, with each structure minimized by PRCG. The solvent for simulation was water.
  • 19
    • 0030939835 scopus 로고    scopus 로고
    • Intramolecular catalysis of cis-to-trans isomerization by an intramo-lecular N-H⋯N hydrogen bond to the imide nitrogen has also been demonstrated with a series of acyl-prolyl-amide model compounds. However, the rate of trans-to-cis isomerization is inhibited due to a shift of the hydrogen bond to the oxygen of the amide bond in the Irans isomer. The model compounds were studied in organic solvents to mimic the desolvated environment of the FKBP active site and to minimize interferences from the formation of hydrogen bonds to water. (a) Cox, C.; Young, V. G., Jr.; Lectka, T. J. Am. Chem. Soc. 1997, 119, 2307-2308.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 2307-2308
    • Cox, C.1    Young V.G., Jr.2    Lectka, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.