Deceptive Multilineage Reconstitution Analysis of Mice Transplanted with Hemopoietic Stem Cells, and Implications for Assessment of Stem Cell Numbers and Lineage Potentials

Journal of Immunology

Volumn 172, Issue 3, 2004, Pages 1548-1552

  Bryder, David ^a   Sasaki, Yutaka ^a   Borge, Ole Johan ^a   Jacobsen, Sten Eirik W ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CD34 ANTIGEN; CD8 ANTIGEN; RB6 8C5 ANTIBODY; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL COUNT; CELL FATE; CELL LINEAGE; CONTROLLED STUDY; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; STEM CELL TRANSPLANTATION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 1642525905     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.3.1548     Document Type: Article

References (27)

1. Anderson, D. J., F. H. Gage, and I. L. Weissman. 2001. Can stem cells cross lineage boundaries? Nat. Med. 7:393.
2. Clarke, D., and J. Frisen. 2001. Differentiation potential of adult stem cells. Curr. Opin. Genet. Dev. 11:575.
3. Spangrude, G. J., S. Heimfeld, and I. L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241:58.
4. Osawa, M., K. Hanada, H. Hamada, and H. Nakauchi. 1996. Long-term lympho-hematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273:242.
5. Forster, I., and K. Rajewsky. 1990. The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc. Natl. Acad. Sci. USA 87:4781.
6. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
7. Audet, J., C. L. Miller, S. Rose-John, J. M. Piret, and C. J. Eaves. 2001. Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 98:1757.
8. Matsuoka, S., Y. Ebihara, M. Xu, T. Ishii, D. Sugiyama, H. Yoshino, T. Ueda, A. Manabe, R. Tanaka, Y. Ikeda, et al. 2001. CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages. Blood 97:419.
9. + bone marrow cells. Exp. Hematol. 26:440.
10. Nichogiannopoulou, A., M. Trevisan, S. Neben, C. Friedrich, and K. Georgopoulos. 1999. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J. Exp. Med. 190:1201.
11. Spangrude, G. J., D. M. Brooks, and D. B. Tumas. 1995. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood 85:1006.
12. Sudo, K., H. Ema, Y. Morita, and H. Nakauchi. 2000. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192:1273.
13. Tajima, F., T. Deguchi, J. H. Laver, H. Zeng, and M. Ogawa. 2001. Reciprocal expression of CD38 and CD34 by adult murine hematopoietic stem cells. Blood 97:2618.
14. Wiesmann, A., R. L. Phillips, M. Mojica, L. J. Pierce, A. E. Searles, G. J. Spangrude, and I. Lemischka. 2000. Expression of CD27 on murine hematopoietic stem and progenitor cells. Immunity 12:193.
15. Zhao, Y., Y. Lin, Y. Zhan, G. Yang, J. Louie, D. E. Harrison, and W. F. Anderson. 2000. Murine hematopoietic stem cell characterization and its regulation in BM transplantation. Blood 96:3016.
16. Bryder, D., V. Ramsfjell, I. Dybedal, K. Theilgaard-Monch, C. M. Hogerkorp, J. Adolfsson, O. J. Borge, and S. E. Jacobsen. 2001. Self-renewal of multipotent long-term repopulating hematopoietic stem cells is negatively regulated by Fas and tumor necrosis factor receptor activation. J. Exp. Med. 194:941.
17. Nilsson, L., I. Astrand-Grundstrom, I. Arvidsson, B. Jacobsson, E. Hellstrom-Lindberg, R. Hast, and S. E. Jacobsen. 2000. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood 96:2012.
18. Bryder, D., and S. E. Jacobsen. 2000. Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro. Blood 96:1748.
19. Harrison, D. E. 1980. Competitive repopulation: a new assay for long-term stem cell functional capacity. Blood 55:77.
20. Uchida, N., A. Tsukamoto, D. He, A. M. Friera, R. Scollay, and I. L. Weissman. 1998. High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J. Clin. Invest. 101:961.
21. + memory T cells by opposing cytokines. Science 288:675.
22. Fleming, T. J., M. L. Fleming, and T. R. Malek. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151:2399.
23. Domen, J., S. H. Cheshier, and I. L. Weissman. 2000. The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of Bcl-2 increases both their number and repopulation potential. J. Exp. Med. 191:253.
24. Shen, F.-W. 1981. Monoclonal antibodies to mouse lymphocyte differentiation alloantigens. In Monoclonal Antibodies and T cell Hybridomas; Perspective and Technical Advances, G. J. Hammerling, U. Hammerling, and J. F. Kearney, ed., p. 25.
25. Domen, J., and I. L. Weissman. 1999. Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate. Mol. Med. Today 5:201.
26. Miller, C. L., and C. J. Eaves. 1997. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc. Natl. Acad. Sci. USA 94:13648.
27. Lagasse, E., and I. L. Weissman. 1996. Flow cytometric identification of murine neutrophils and monocytes. J. Immunol. Methods 197-139.