Discrepancy between in vitro and in vivo dose variability for a pressurized metered dose inhaler and a dry powder inhaler

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 11, Issue SUPPL. 1, 1998, Pages

  Borgstrom L ^a   Asking, L ^a   Beckman, O ^a   Bondesson, E ^a   Kallen A ^a   Olsson, B ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TERBUTALINE;

CONFERENCE PAPER; DOSE CALCULATION; DRUG FORMULATION; DRY DEPOSITION; DRY POWDER; HUMAN; LUNG INFILTRATE; METERED DOSE INHALER; STANDARDIZATION;

EID: 0031833291     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1998.11.suppl_1.s-59     Document Type: Conference Paper

References (7)

1. Borgström, L., E. Derom, E. Ståhl, E. Wåhlin-Boll, and R. Pauwels. 1996. The inhalation device influences lung deposition and bronchodilating effect of terbutaline. Am. J. Respir. Crit. Care Med. 153:1636-1640.
2. Newman, S.P. 1993. Scintigraphic assessment of therapeutic aerosols. Crit. Rev. Ther. Drug Carr. Systems. 10:65-109.
3. Borgström, L., and M. Nilsson. 1990. A method for determination of the absolute pulmonary bioavailability of inhaled drugs: Terbutaline. Pharm. Res. 7:1068-1070.
4. Borgström, L., S. Newman, A.A. Weisz, and F. Morén. 1992. Pulmonary deposition of inhaled terbutaline: Comparison of scanning gamma camera and urinary excretion methods. J. Pharm. Sci. 81:753-755.
5. Newman, S., K. Steed, G. Hooper, A. Källén, and L. Borgström. 1995. Comparison of gamma scintigraphy and a pharmacokinetic technique for assessing pulmonary deposition of terbutaline sulphate delivered by pressurized metered dose inhaler. Pharm. Res. 12:231-236.
6. Beckman, O., E. Bondesson, L. Asking, A. Källén, and L. Borgström. 1996. Intra- and interindividual variations in pulmonary deposition via Turbuhaler and a pMDI. J. Aerosol Med.
7. Svartengren, K., P-Å. Lindestad, M. Svartengren, K. Philipsson, G. Bylin, and P. Camner. 1995. Added external resistance reduces oropharyngeal deposition and increases lung deposition of aerosol particles in asthmatics. Am. J. Resp. Crit. Care Med. 152:32-37.