Low-dose intravaginal estradiol delivery using a Silastic vaginal ring for estrogen replacement therapy in postmenopausal women: A review

European Journal of Contraception and Reproductive Health Care

Volumn 8, Issue 4, 2003, Pages 217-224

  Sarkar, N N ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Climacteric symptoms; Estrogen deficiency; Hot flush; Maturation index; Night sweat; Urogenital tract; Vaginal pH

Indexed keywords

ESTRADIOL; MENORING; PROGESTERONE; SILASTIC;

CELL MATURATION; CELL PROLIFERATION; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; ESTROGEN THERAPY; FEMALE; HUMAN; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; LOW DRUG DOSE; MENOPAUSAL SYNDROME; META ANALYSIS; MUCOSA CELL; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SUSTAINED RELEASE PREPARATION; VAGINA MUCOSA; VAGINA PESSARY; VAGINA RING; VULVA;

EID: 1642503901     PISSN: 13625187     EISSN: None     Source Type: Journal    
DOI: 10.1080/ejc.8.4.217.224     Document Type: Review

References (25)

1. Bachmann GA. The clinical platform for the 17-beta-estradiol vaginal releasing ring. Am J Obstet Gynecol 1998;178:8257-60
2. Shaupe D. HRT dosing regimens: continuous versus cyclic - pros and cons. Int J Fertil 2001;46:7-15
3. Henriksson L, Stjernquist M, Boquist L, Cedergren I, Selinus I. A one-year multi-centre study of efficacy and safety of a continuous, low-dose, estradiol-releasing vaginal ring (Estring) in postmenopausal women with symptoms and signs of urogenital aging. Am J Obstet Gynecol 1996;174:85-92
4. Smith P. Estrogen and the urogenital tract: studies on estradiol hormone receptors and a clinical study on a new estradiol releasing vaginal ring. Acta Obstet Gynecol Scand 1993;72(Suppl 157):1-26
5. Eriksen B. A randomised, open, parallel-group study on the preventive effect of an estradiol releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women. Am J Obstet Gynecol 1999; 180:1072-9
6. Schmidt G, Andersson SB, Nordle O, Johansson CJ, Gunersson PO. Release of 17-beta estradiol from a vaginal ring in postmenopausal women: pharmacokinetic evaluation. Gynecol Obstet Invest 1994;38: 253-60
7. Smith P, Heimer G, Lindskog M, Ulmsten U. Estradiol releasing vaginal ring for treatment of postmenopausal urogenital atrophy. Maturitus 1993;16:145-54
8. Holmgren PA, Lindskog M, von Schoulz B. Vaginal ring for continuous low-dose release of estradiol in the treatment of urinogenital atrophy. Maturitus 1989;11; 55-63
9. Gabrielsson J, Wallenbeck Z, Birgerson L. The pharmacokinetic data on estradiol in light of the estring concept. Estradiol and estring pharmacokinetics. Acta Obstet Gynecol Scand 1996;75(Suppl 163):26-31
10. Johnston A. Estrogen - pharmacokinetics and pharmacodynamics with a special reference to vaginal administration and the new estradiol formulation - Estring® Acta Obstet Gynecol Scand 1996;75(Suppl 163):16-25
11. Lose G, Englev K. Estradiol-releasing vaginal ring versus oestriol vaginal pessaries in the treatment of bothersome lower urinary tract symptoms. Br J Obstet Gynaecol 2000;107:1029-34
12. Casper F, Petri K, Benninghoff B. Continuous, low dosage estradiol administration with a vaginal ring: a placebo-controlled study. Zentralbl Gynakol 1998;120: 449-53
13. Barentsen R, van de Weijer PH, Schram JH. Continuous low-dose estradiol released from a vaginal ring versus estriol vaginal cream for urogenital atrophy. Eur J Obstet Gynecol Reprod Biol 1997;71:73-80
14. Ayton RA, Darling GM, Murkies AL, et al. A comparative study of safety and efficacy of continuous low-dose estradiol released from a vaginal ring compared with conjugated equine estrogen vaginal cream in the treatment of postmenopausal urogenital atrophy. Br J Obstet Gynaecol 1996;103:351-8
15. Bachmann G. Estradiol releasing vaginal ring delivery system for urogenital atrophy. Expenence over past decade. J Reprod Med 1998;43:991-8
16. Buckler H, Al-Azzawi F, UK-VR Multi-centre trial group. The effect of a novel vaginal ring delivering estradiol acetate on climacteric symptoms in postmenopausal women. Br J Obstet Gynaecol 2003;110:753-9
17. Al-Azzawi F, Buckler H, UK-VR trial group. Comparison of a novel vaginal ring delivering estradiol acetate versus oral estradiol for relief of vasomotor menopausal symptoms. Climacteric 2003;6:118-27
18. Hamada AL, Maruo T, Samoto T, et al. Estradiol/ progesterone releasing vaginal rings for hormone replacement therapy in postmenopausal women. Gynecol Endocrinol 2003;17:247-54
19. Botsis D, Kassanos D, Kalogirou D, Antoniou G, Karakitsos P, Zourlas PA. A comparative study of an estradiol-releasing vaginal ring versus tibolone in postmenopausal women: a transvaginal colour Doppler study. Maturitus 1997;27:77-93
20. Antoniou G, Kalogirou D, Karakitsos P, Antoniou D, Kalogirou O, Giannikos L. Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints versus estradiol releasing vaginal ring with a vaginal progesterone suppository: clinical and endometrial responses. Maturitus 1997; 26:103-11
21. Kalogirou D, Antoniou G, Karakitsos P, Kalogirou O, Antoniou D, Giannikos L. A comparative study of the effects of an estradiol-releasing vaginal ring combined with an oral gestogen versus transdermal estrogen combined with a levonorgestrel-releasing IUD: clinical findings and endometrial response. Int J Fertil Menopausal Study 1996;41:522-7
22. Weisberg E, Fraser I-S, Baker J, et al. A randomised comparison of the effects on vaginal and cervical epithelium of a placebo vaginal ring with non-use of ring. Contraception 2000;62:83-9
23. Naessen T, Rodriguez-Macias K, Lithel H. Serum lipid profile unproved by ultra-low doses of 17-beta-estradiol in elderly women. J Clin Endocrinol Metab 2001;86:2757-62
24. Henriksson L, Stjernquist M, Boquist L, Alander U, Selinus I. A comparative multi-center study of the effects of continuous low-dose estradiol released from a new vaginal ring versus estriol vaginal pessaries in postmenopausal women with symptoms and signs of urogenital atrophy. Am J Obstet Gynecol 1994;171: 624-32
25. Casper F, Petri E. Local treatment of urogenital atrophy with an estradiol releasing vaginal ring: a comparative and placebo-controlled multi-centre study. Vaginal ring group. Int Urogynecol Pelvic Floor Dysfunct 1999; 10:171-6