A collaborative model for research on decisional capacity and informed consent in older patients with schizophrenia: Bioethics unit of a geriatric psychiatry intervention research center

Psychopharmacology

Volumn 171, Issue 1, 2003, Pages 68-74

  Jeste, Dilip V ^a   Dunn, Laura B ^a   Palmer, Barton W ^a   Saks, Elyn ^b   Halpain, Maureen ^a   Cook, Alison ^c   Appelbaum, Paul ^d   Schneiderman, Lawrence ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c Adult Protective Services Inc   (United States)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Aging; Bioethics; Competency; Informed consent; Schizophrenia

Indexed keywords

CLINICAL RESEARCH; COMPETENCE; DECISION MAKING; GERONTOPSYCHIATRY; HUMAN; INFORMED CONSENT; MENTAL CAPACITY; MENTAL PATIENT; PRIORITY JOURNAL; RESEARCH ETHICS; REVIEW; SENESCENCE; TEAMWORK; THEORETICAL MODEL;

ADVISORY COMMITTEES; AGED; BIOETHICAL ISSUES; BIOMEDICAL RESEARCH; DECISION MAKING; HUMANS; INFORMED CONSENT; INTERDISCIPLINARY COMMUNICATION; MENTAL COMPETENCY; PATIENT SELECTION; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 1642496973     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1507-x     Document Type: Review

References (43)

1. American Psychological Association Ethics Committee (1992) Ethical principles of psychologists and code of conduct. Am Psychol 47:1597-1611
2. Appelbaum PS (2002) Involving decisionally impaired subjects in research: the need for legislation. Am J Geriatr Psychiatr 10:120-124
3. Appelbaum PS, Grisso T (1995) The MacArthur treatment competence study. I. Mental illness and competence to consent to treatment. Law Hum Behav 19:105-126
4. Baker MT, Taub HA (1983) Readability of informed consent forms for research in a Veterans Administration Medical Center. JAMA 250:2646-2648
5. Beck JC (1988) Determining competency to assent to neuroleptic drug treatment. Hosp Commun Psychiatry 39:1106-1108
6. Beck JC, Staffin RD (1986) Patients' competency to give informed consent to medication. Hosp Commun Psychiatry 37:400-402
7. Bjerrum L, Sogaard J, Hallas J, Kragstrup J (1998) Polypharmacy: correlations with sex, age and drug regimen: a prescription database study. Eur J Clin Pharmacol 54:197-202
8. Carpenter WT, Gold JM, Lahti AC, Queern CA, Conley RR, Bartko JJ, Kovnick J, Appelbaum PS (2000) Decisional capacity for informed consent in schizophrenia research. Arch Gen Psychiatry 57:533-538
9. Christensen K, Haroun A, Schneiderman LJ, Jeste DV (1995) Decision-making capacity for informed consent in the older population. Bull Am Acad Psychiatr Law 23:353-365
10. Doucet J, Chassagne P, Trivalle C, Landrin I, Pauty MD, Kadri N, Menard JF, Bercoff E (1996) Drug-drug interactions related to hospital admissions in older adults: a prospective study of 1000 patients. J Am Geriatr Soc 44:944-948
11. Dunn LB, Jeste DV (2001) Enhancing informed consent for research and treatment. Neuropsychopharmacology 24:595-607
12. Dunn LB, Lindamer LA, Palmer BW, Schneiderman LJ, Jeste DV (2001) Enhancing comprehension of consent for research in older patients with psychosis: a randomized study of a novel educational strategy. Am J Psychiatry 158:1911-1913
13. Dunn LB, Lindamer LA, Palmer BW, Golshan S, Schneiderman LJ, Jeste DV (2002) Improving understanding of research consent in middle-aged and elderly patients with psychotic disorders. Am J Geriatr Psychiatry 10:142-150
14. Fins JJ, Miller FG (2000) Enrolling decisionally incapacitated subjects in neuropsychiatric research. CNS Spect 5:32-42
15. Grisso T, Appelbaum PS (1995) The MacArthur Treatment Competence Study. III. Abilities of patients to consent to psychiatric and medical treatments. Law Hum Behav 19:149-174
16. Grisso T, Appelbaum PS, Mulvey EP, Fletcher K (1995) The MacArthur Treatment Competence Study: II. measures of abilities related to competence to consent to treatment. Law Hum Behav 19:127-148
17. Grossman L, Summers F (1980) A study of the capacity of schizophrenic patients to give informed consent. Hosp Commun Psychiatry 31:205-206
18. Herz DA, Looman JE, Lewis SK (1992) Informed consent: Is it a myth? Neurosurgery 30:453-458
19. Hutson MM, Blaha JD (1991) Patients' recall of preoperative instruction for informed consent for an operation. J Bone Joint Surg 73-A:160-162
20. Irwin M, Lovitz A, Marder SR, Mintz J, Winslade WJ, Van Putten T, Mills MJ (1984) Psychotic patients' understanding of informed consent. Am J Psychiatry 142:1351-1354
21. Jeste DV (2000) Tardive dyskinesia in older patients. J Clin Psychiatry 61:27-32
22. Jeste DV, Alexopoulos GS, Bartels SJ, Cummings J, Gallo JJ, Gottlieb GL, Halpain MC, Palmer BW, Patterson TL, Reynolds CF, Lebowitz BD (1999a) Consensus statement: the upcoming crisis in geriatric mental health: challenges and opportunities. Arch Gen Psychiatry 56:848-853
23. Jeste DV, Lacro JP, Palmer BW, Rockwell E, Harris MJ, Caligiuri M (1999b) Incidence of tardive dyskinesia in early stages of low-dose treatment with typical neuroleptics in older patients. Am J Psychiatry 156:309-311
24. Karlawish JH, Lantos J (1997) Community equipoise and the architecture of clinical research. Cambridge Q Healthcare Ethics 6:385-396
25. Kim SYH, Caine ED, Currier GW, Leibovici A, Ryan JM (2001) Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in research. Am J Psychiatry 158:712-717
26. Kim SYH, Karlawish JHT, Caine ED (2002) Current state of research on decision-making competence of cognitively impaired elderly persons. Am J Geriatr Psychiatry 10:151-165
27. Kramarow E, Lentzner H, Rooks R, Weeks J, Saydah S (1999) Health and aging chartbook, health, United States. National Center for Health Studies, Hyattsville, Md.
28. Marson DC, Earnst KS, Jamil F, Bartolucci A, Harrell LE (2000) Consistency of physicians' legal standard and personal judgments of competency in patients with Alzheimer's disease. J Am Geriatr Soc 48:911-918
29. Michels R (1999) Are research ethics bad for our mental health? N Engl J Med 340:1427-1430
30. National Bioethics Advisory Commission (1998) Research involving persons with mental disorders that may affect decision-making capacity. Report of the Recommendations of the National Bioethics Advisory Commission. National Bioethics Advisory Commission, Rockville, Md.
31. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978) The Belmont Report: ethical principles and guidelines for the protection of human subjects of research
32. Palmer BW, Heaton SC, Jeste DV (1999) Older patients with schizophrenia: challenges in the coming decades. Psychiatr Serv 50:1178-1183
33. Palmer BW, Nayak GV, Dunn LB, Appelbaum PS, Jeste DV (2002) Treatment-related decision-making capacity in middle-aged and older patients with psychosis: a preliminary study using the MacCAT-T and HCAT. Am J Geriatr Psychiatry 10:207-211
34. Reynolds CF (2002) Advancing research in decision-making capacity: An opportunity for leadership - and an obligation of geriatric psychiatry. Am J Geriatr Psychiatry 10:117-119
35. Roberts LW (2000) Evidence-based ethics and informed consent in mental illness research. Arch Gen Psychiatry 57:540-542
36. Roberts LW, Roberts B (1999) Psychiatric research ethics: an overview of evolving guidelines and current ethical dilemmas in the study of mental illness. Biol Psychiatry 46:1025-1038
37. Roberts LW, Warner TD, Brody JL (2000) Perspectives of patients with schizophrenia and psychiatrists regarding ethically important aspects of research participation. Am J Psychiatry 157:67-74
38. Rothman DJ (1987) Ethics and human experimentation: Henry Beecher revisited. N Engl J Med 317:1195-1199
39. Saks ER, Behnke SH (1999) Competency to decide on treatment and research: MacArthur and beyond. J Contemp Legal Issues 10:103-129
40. Saks ER, Dunn LB, Marshall BJ, Nayak GV, Golshan S, Jeste DV (2002) The California Scale of Appreciation: a new instrument to measure the appreciation component of capacity to consent to research. Am J Geriatr Psychiatry 10:166-174
41. Steffens DC, Rama Krishan KR (1998) Psychotherapeutic agents in older adults. Clin Geriatr Med 14:17-31
42. Sugarman J, McCrory DC, Hubal RC (1998) Getting meaningful informed consent from older adults: a structured literature review of empirical research. J Am Geriatr Soc 46:517-524
43. Wirshing DA, Wirshing WC, Marder SR, Liberman RP, Mintz J (1998) Informed consent: assessment of comprehension. Am J Psychiatry 155:1508-1511