Simultaneous determination of 6β-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6β-hydroxylation clearance

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 801, Issue 2, 2004, Pages 165-171

  Furuta, Takashi ^a   Mori, Chieko ^a   Suzuki, Atsushi ^a   Shibasaki, Hiromi ^a   Yokokawa, Akitomo ^a   Kasuya, Yasuji ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

6 Hydroxycortisol; Cortisol; CYP3A activity; Phenotyping

Indexed keywords

ASSAYS; CORRELATION METHODS; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC COMPOUNDS;

HUMAN URINE;

BODY FLUIDS;

6BETA HYDROXYHYDROCORTISONE; ACETONITRILE; BECLOMETASONE; CYTOCHROME P450 3A; HYDROCORTISONE; METHYLPREDNISOLONE; POTASSIUM DERIVATIVE; 6 BETA-HYDROXYCORTISOL; ANTIINFECTIVE AGENT; CLARITHROMYCIN; DRUG DERIVATIVE; N DEMETHYLASE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; ELUTION; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; INTERMETHOD COMPARISON; MASS SPECTROMETRY; MONITORING; PH; PHENOTYPE; PRIORITY JOURNAL; REPRODUCIBILITY; SEPARATION TECHNIQUE; STANDARDIZATION; ULTRAVIOLET RADIATION; URINALYSIS; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; SENSITIVITY AND SPECIFICITY; URINE;

ANTI-BACTERIAL AGENTS; ARYL HYDROCARBON HYDROXYLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLARITHROMYCIN; CYTOCHROME P-450 CYP3A; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROCORTISONE; HYDROXYLATION; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 1642482472     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.11.001     Document Type: Article

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