Characterisation of [123I]iomazenil distribution in a rat model of focal cerebral ischaemia in relation to histopathological findings

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 31, Issue 1, 2004, Pages 64-70

  Kaji, Tomohito ^a   Kuge, Yuji ^a   Yokota, Chiaki ^b   Tagaya, Masafumi ^c   Inoue, Hiroyasu ^b   Shiga, Tohru ^a   Minematsu, Kazuo ^b   Tamaki, Nagara ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c Department of Radiology   (Japan)

Author keywords

123I iomazenil; Cerebral ischaemia; Cyclooxygenase 2; DNA fragmentation; Neuronal viability

Indexed keywords

CYCLOOXYGENASE 2; DNA FRAGMENT; IOMAZENIL I 123; MICROTUBULE ASSOCIATED PROTEIN 2; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUMAZENIL; IOMAZENIL; RADIOACTIVE IODINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN SCINTISCANNING; CALCULATION; CELL VIABILITY; DIAGNOSTIC IMAGING; DRUG DISTRIBUTION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR DYNAMICS; NEUROIMAGING; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; EVALUATION; METABOLIC CLEARANCE RATE; METABOLISM; PATHOLOGY; SCINTISCANNING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; VALIDATION STUDY;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; FLUMAZENIL; IODINE RADIOISOTOPES; MALE; METABOLIC CLEARANCE RATE; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 1642471699     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-003-1319-6     Document Type: Article

References (28)

1. Garcia JH, Lassen NA, Weiller C, Sperling B, Nakagawara J. Ischemic stroke and incomplete infarction. Stroke 1996; 27:761-765.
2. Garcia JH, Liu KF, Ye ZR, Gutierrez JA. Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats. Stroke 1997; 28:2303-2310.
3. Nakagawara J, Sperling B, Lassen NA. Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil. Stroke 1997; 28:124-132.
4. Heiss WD, Graf R, Fujita T, Ohta K, Bauer B, Lötten J, Wienhard K. Early detection of irreversibly damaged ischemic tissue by flumazenil positron emission tomography in cats. Stroke 1997; 28:2045-2052.
5. Heiss WD, Kracht LW, Thiel A, Grond M, Pawlik G. Penumbral probability thresholds of cortical flumazenil binding and blood flow prediction tissue outcome in patients with cerebral ischaemia. Brain 2001; 124:20-29.
6. 14C-labeled 2-deoxyglucose autoradiography and histological examination. Nucl Med Commun 1996; 16:443-446.
7. 99mTc-HMPAO in experimental brain ischemia. Nucl Med Commun 1995; 16:581-590.
8. 123I]IMZ and SPECT. Stroke 1995; 26:2267-2271.
9. Dong Y, Fukuyama H, Nabatame H, Yamauchi H, Shibasaki H, Yonekura Y. Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. Stroke 1997; 28:1776-1782.
10. Toyama H, Matsumura K, Nakashima H, Takeda K, Takeuchi A, Koga S, Yoshida T, Ichise M. Characterization of neuronal damage by iomazenil binding and cerebral blood flow in an ischemic rat model. Ann Nucl Med 1998; 12:267-273.
11. Watanabe Y, Nakano T, Yutani K, Nishimura H, Kusuoka H, Nakamura H, Nishimura T. Detection of viable cortical neurons using benzodiazepine receptor imaging after reversible focal ischaemia in rats: comparison with regional cerebral blood flow. Eur J Nucl Med 2000; 27:308-313.
12. al-Tikriti MS, Dey HM, Zoghbi SS, Baldwin RM, Zea-Ponce Y, Innis RB. Dual-isotope autoradiographic measurement of regional blood flow and benzodiazepine receptor availability following unilateral middle cerebral artery occlusion. Eur J Nucl Med 1994; 21:196-202.
13. Nogawa S, Zhang F, Ross ME, Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 1997; 17:2746-2755.
14. Sairanen T, Ristimaki A, Karjalainen-Lindsberg ML, Paetau A, Kaste M, Lindsberg PJ. Cyclooxygenase-2 is induced globally in infarcted human brain. Ann Neurol 1998; 43:738-747.
15. Iadecola C, Forster C, Nogawa S, Clark HB, Ross ME. Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. Acta Neuropathol (Berl) 1999; 98:9-14.
16. Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA. Cyclooxygenase-2 contributes to N-methyl-D-asparatate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther 2000; 293:417-425.
17. Takedera T, Yumoto H, Tozuka Y, Ohyashiki T. Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells. Neurosci Lett 2002; 317:61-64.
18. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119:493-501.
19. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniotomy in rats. Stroke 1989; 20:84-91.
20. Minematsu K, Li L, Fisher M, Sotak CH, Davis MA, Fiandaca MS. Diffusion-weighted magnetic resonance imaging:rapid and quantitative detection of focal brain ischemia. Neurology 1992; 42:235-240.
21. Kuge Y, Minematsu K, Yamaguchi T, Miyake Y. Nylon monofilament for intraluminal middle cerebral artery occlusion in rats. Stroke 1995; 26:1655-1658.
22. Sternberger LA, Sternberger NH. The unlabeled antibody method: comparison of peroxidase-antiperoxidase with avidin-biotin complex by a new method of quantification. J Histochem Cytochem 1986; 34:599-605.
23. Tagaya M, Liu K, Copeland B, Seiffert D, Engler R, Garcia JH, Zoppo GJ. DNA scission after focal brain ischemia/temporal differences in two species. Stroke 1997; 28:1245-1254.
24. 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent. Part 4. Report on clinical usefulness in diagnosis of cerebrovascular diseases. Kaku Igaku 1996; 33:329-344.
25. Moriwaki H, Matsumoto M, Hashikawa K, Oku N, Ishida M, Seike Y, Fukuchi K, Hori M, Nishimura T. Iodine-123-iomazenil and iodine-123-iodoamphetamine SPECT in major cerebral artery occlusive disease. J Nucl Med 1998; 39:1348-1353.
26. Matsuoka Y, Okazaki M, Zhao H, Asai S, Ishikawa K, Kitamura Y. Phosphorylation of c-Jun and its localization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia. J Cereb Blood Flow Metab 1999; 19:1247-1255.
27. Heiss WD, Grond M, Thiel A, Ghaemi M, Sobesky J, Bauer B, Wienhard K. Permanent cortical damage detected by flumazenil positron emission tomography in acute stroke. Stroke 1998; 29:454-461.
28. 2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke 2000; 31:366-369.