Reduction in Glycopeptide Resistance in Vancomycin-Resistant Enterococci as a Result of vanA Cluster Rearrangements

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 4, 2004, Pages 1379-1381

  Lee, Wee Gyo ^a,b   Huh, Ji Young ^a   Cho, Sung Ran ^a   Lim, Young Ae ^a  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPEPTIDE; SPACER DNA; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; ENTEROCOCCUS; GENE CLUSTER; GENE REARRANGEMENT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; VANA GENE; VANX GENE; VANY GENE; VANZ GENE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CARBON-OXYGEN LIGASES; CHROMOSOME MAPPING; CHROMOSOMES, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; ENTEROCOCCUS FAECIUM; GENES, BACTERIAL; GENOTYPE; GLYCOPEPTIDES; GRAM-POSITIVE BACTERIAL INFECTIONS; KOREA; MULTIGENE FAMILY; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VANCOMYCIN RESISTANCE;

EID: 1642461344     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.4.1379-1381.2004     Document Type: Article

References (13)

1. Araoz, R., E. Anhalt, L. Rene, M. A. Badet-Denisot, P. Courvalin, and B. Badet. 2000. Mechanism-based inactivation of VanX, a D-alanyl-D-alanine dipeptidase necessary for vancomycin resistance. Biochemistry 39:15971-15979.
2. Arthur, M., and P. Courvalin. 1993. Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob. Agents Chemother. 37:1563-1571.
3. Arthur, M., F. Depardieu, C. Molinas, P. Reynolds, and P. Courvalin. 1995. The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene 154:87-92.
4. Arthur, M., F. Depardieu, P. Reynolds, and P. Courvalin. 1996. Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol. Microbiol. 21:33-44.
5. Arthur, M., C. Molinas, and P. Courvalin. 1992. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174:2582-2591.
6. Arthur, M., C. Molinas, F. Depardieu, and P. Courvalin. 1993. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 175:117-127.
7. Clark, N. C., R. C. Cooksey, B. C. Hill, J. M. Swenson, and F. C. Tenover. 1993. Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob. Agents Chemother. 37:2311-2317.
8. Hashimoto, Y., K. Tanimoto, Y. Ozawa, T. Murata, and Y. Ike. 2000. Amino acid substitutions in the VanS sensor of the VanA-type vancomycin-resistant Enterococcus strains result in high-level vancomycin resistance and low level teicoplanin resistance. FEMS Microbiol. Lett. 185:247-254.
9. Lauderdale, T.-L., L. C. McDonald, Y. R. Shiau, P. C. Chen, H. Y. Wang, J. F. Lai, and M. Ho. 2002. Vancomycin-resistant enterococci from humans and retail chickens in Taiwan with unique VanB phenotype-vanA genotype incongruence. Antimicrob. Agents Chemother. 46:525-527.
10. Murray, B. E., K. V. Singh, J. D. Heath, B. R. Sharma, and G. M. Weinstock. 1990. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J. Clin. Microbiol. 28:2059-2063.
11. Reynolds, P. E., F. Depardieu, S. Dutka-Malen, M. Arhtur, and P. Courvalin. 1994. Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol. Microbiol. 13:1065-1070.
12. Simonsen, G. S., M. R. M. Myhre, K. H. Dahl, Ø. Olsvik, and A. Sundsfjord. 2000. Typeability of Tn1546-like elements in vancomycin-resistance enterococci using long-range PCRs and specific analysis of polymorphic regions. Microb. Drug Resist. 6:49-57.
13. Woodford, N., D. Morrison, B. Cookson, and R. C. George. 1993. Comparison of high-level gentamicin-resistant Enterococcus faecium isolates from different continents. Antimicrob. Agents Chemother. 37:681-684.