Cardiac disease in myasthenia gravis: A literature review

Journal of Clinical Neuromuscular Disease

Volumn 4, Issue 4, 2003, Pages 199-203

  Guglin, Maya ^a   Campellone, Joseph V ^a   Heintz, Kathleen ^a   Parrillo, Joseph E ^a,b  

^a Division of Female Pelvic Medicine and Reconstructive Surgery   (United States)

^b Robert Wood Johnson Medical School ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLINERGIC RECEPTOR; CHOLINESTERASE INHIBITOR; DIGITALIS; MUSCLE ANTIBODY; NEOSTIGMINE; PYRIDOSTIGMINE; RYANODINE RECEPTOR; STEROID;

ATRIOVENTRICULAR DISSOCIATION; BRADYCARDIA; CAUSE OF DEATH; CHOLINESTERASE INHIBITION; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; ELECTROCARDIOGRAM; ELECTROLYTE DISTURBANCE; GUINEA PIG; HEART ARRHYTHMIA; HEART CONDUCTION; HEART DISEASE; HUMAN; HYPOKALEMIA; MALAISE; MEDICAL LITERATURE; MYASTHENIA GRAVIS; MYOCARDITIS; NONHUMAN; POPULATION RESEARCH; PRIORITY JOURNAL; QRS COMPLEX; REVIEW; SUDDEN DEATH; SYMPTOMATOLOGY; TACHYCARDIA; THYMECTOMY; THYMOMA;

EID: 1642444185     PISSN: 15220443     EISSN: None     Source Type: Journal    
DOI: 10.1097/00131402-200306000-00006     Document Type: Review

References (65)

1. Hofstad H, Ohm OJ, Mork SJ, et al. Heart disease in myasthenia gravis. Acta Neurol Scand. 1984;70:176-184.
2. Rowland LP, Hoefer PFA, Aranow H, et al. Fatalities in myasthenia gravis. A review of 39 cases with 26 autopsies. Neurology. 1956;6:307.
3. Kohn PM, Tucker HJ, Kozokoff NJ. The cardiac manifestations of myasthenia gravis with particular reference to electrocardiographic abnormalities. Am J Med Sci. 1965;249:561-569.
4. Weigert C. Pathologisch-anatomischer Beitrag zur Erb's schen Krankenheit. Neurol Zentralbl. 1901;20:597.
5. Rottino A, Poppitti R, Rao J. Myocardial lesions in myasthenia gravis. Arch Pathol. 1942;34:557-561.
6. Taquini AC, Cooke WT, Schwab RS. Observations on the cardiovascular system in myasthenia gravis. Am Heart J 1940;20: 611.
7. Brem J, Wechsler HF. Myasthenia gravis associated with thymoma. Report of two cases with autopsy. Arch Intern Med. 1934;54:901-915.
8. Barton FE, Branch CF. Studies on myasthenia gravis: Report of a case with necropsy. JAMA. 1937;109:2044-2048.
9. Davies MJ, Pomerance A, Teare RD. Idiopathic giant cell myocarditis - a distinctive clinico-pathological entity. Br Heart J. 1975;37:192-195.
10. Gibson TC. The heart in myasthenia gravis. Am Heart J. 1975; 90:389-396.
11. Kloin JE. Pernicious anemia and giant cell myocarditis. New association. Am J Med. 1985;78:355-360.
12. Russell DS. Histological changes in the striped muscles in myasthenia gravis. J Pathol Bacteriol. 1953;65:279.
13. Kilgallen CM, Jackson E, Bankoff M, et al. A case of giant cell myocarditis and malignant thymoma: A postmortem diagnosis by needle biopsy. Clin Cardiol. 1998;21:48-51.
14. Huvos AG, Pruzanski W. Smooth muscle involvement in primary muscle diseases. 3. Myasthenia gravis. Arch Pathol. 1967; 84:280-285.
15. Held H, Bass L. [Myocardial involvement in myasthenia gravis pseudoparalytica.] Z Kardiol. 1973;62:450-465.
16. Feeley KM, Harris J, Suvarna SK. Necropsy diagnosis of myocarditis: A retrospective study using CD45RO immunohistochemistry. J Clin Pathol. 2000;53:147-149.
17. Genkins G, Papatestas AE, Horowitz SH, et al. Studies in myasthenia gravis: Early thymectomy. Electrophysiologic and pathologic correlations. Am J Med. 1975;58:517-524.
18. Glennon PE, Petersen ME, Sheppard MN. Fatal giant cell myocarditis after resection of thymoma. Heart. 1996;75:531-532.
19. Pentz WH. Advanced heart block as a manifestation of a paraneoplastic syndrome from malignant thymoma. Chest. 1999;116: 1135-1136.
20. Clinical conferences at The Johns Hopkins Hospital. Thymoma with myositis and myocarditis. Johns Hopkins Med J. 1977;140: 69-75.
21. Oosterhius HJGH. Studies in myasthenia gravis. Part 1. A clinical study of 180 patients. J Neurol Sci. 1964;1:512-546.
22. Kanzato N, Nakasone I, Sunagawa O, et al. [Giant-cell myocarditis without a symptom of heart failure seen in a patient with myasthenia gravis and concurrent Hashimoto's disease.] Rinsho Shinkeigaku. 2001;41:813-817.
23. Namba T, Brunner NG, Grob D. Association of myasthenia gravis with pemphigus vulgaris, Candida albicans infection, polymyositis and myocarditis. J Neurol Sci. 1973;20:231-242.
24. Namba T, Grob D. Autoantibodies and myasthenia gravis, with special reference to muscle ribonucleoprotein. Ann N Y Acad Sci. 1966;135:606-630.
25. Reznik M. Two cases of myasthenic syndrome with thymoma, polymyositis, myocarditis, and thyroiditis. J Neurol Sci. 1974;22: 341-351.
26. Klein HO, Lennartz KJ. [On syntropy of myasthenia gravis, polymyositis, myocarditis and thymoma; at the same time a contribution to pathogenesis.] Dtsch Med Wochenschr. 1966;91:1727-1730.
27. de Jongste MJ, Oosterhuis HJ, Lie KI. Intractable ventricular tachycardia in a patient with giant cell myocarditis, thymoma and myasthenia gravis. Int J Cardiol. 1986;13:374-378.
28. Burke JS, Medline NM, Katz A. Giant cell myocarditis and myositis associated with thymoma and myasthenia gravis. Arch Pathol. 1969;88:359-366.
29. Bourgeois-Droin C, Sauvanet A, Lemarchand F, et al. [Thymoma associated with myasthenia, erythroblastopenia, myositis and giant cell myocarditis. One case (author's transl.).]. Nouv Presse Med 1981;10:2097-2098, 2103-2094.
30. Tomimoto H, Akiguchi I, Kameyama M, et al. [Giant cell myositis and myocarditis associated with myasthenia gravis and thymoma - an autopsy case.] Rinsho Shinkeigaku. 1985;25:688-693.
31. Luomanmaki K, Hokkanen E, Heikkila J. Electrocardiogram in myasthenia gravis. Analysis of a series of 97 patients. Ann Clin Res. 1969;1:236-245.
32. Buyukozturk K, Ozdemir C, Kohen D. Electrocardiographic findings in 24 patients with myasthenia gravis. Acta Cardiol. (Brux). 1976;31:301-305.
33. Ashok PP, Ahuja GK, Manchanda SC, et al. Cardiac involvement in myasthenia gravis. Acta Neurol Scand. 1983;68:113-120.
34. Mygland A, Gilhus NE, Hofstad H, et al. [Heart disease in myasthenia gravis.] Tidsskr Nor Laegeforen. 1990;110: 1209-1211.
35. Mygland A, Tysnes OB, Matte R, et al. Anti-cardiac ryanodine receptor antibodies in thymoma-associated myasthenia gravis. Autoimmunity. 1994;17:327-331.
36. Arsura EL, Brunner NG, Namba T, et al. Adverse cardiovascular effects of anticholinesterase medications. Am J Med Sci. 1987; 293:18-23.
37. Morpurgo M, Beulcke G, Colombo B, et al. [The heart in myasthenia gravis. Electrocardiographic, cardiodynamic and kinetocardiographic aspects in 18 cases.] Schweiz Med Wochenschr. 1976; 106:443-449.
38. Johannessen KA, Mygland A, Gilhus NE, et al. Left ventricular function in myasthenia gravis. Am J Cardiol. 1992;69:129-132.
39. Zhang TH. [Detection of a negligible lesion of heart function in myasthenia gravis by noninvasive technics.] Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1987;20:276-279.
40. Strauss AJL, Seegal BC, Hsu KC, et al. Immunofluorescence demonstration of muscle- binding, complement-fixing serum globulin fraction in myasthenia gravis. Soc Exp Biol Med. 1960; 105:184.
41. Connor RI, Lefvert AK, Benes SC, et al. Incidence and reactivity patterns of skeletal and heart (SH) reactive autoantibodies in the sera of patients with myasthenia gravis. J Neuroimmunol. 1990; 26:147-157.
42. Beutner EH, Witebsky E, Ricken D, et al. Studies on autoantibodies in myasthenia gravis. JAMA. 1962;182:146.
43. Mehl VS, Lang RW. Myasthenia gravis. Identification of skeletal and heart muscle antigens not related to the acetylcholine receptor. J Neuroimmunol. 1984;6:347-360.
44. Cossio PM, Cornejo L, Herrera M, et al. Skeletal and heart muscle antibodies in myasthenia gravis. A new immunofluorescence pattern. Biomedicine. 1973;19:261-266.
45. Beutner EH, Witebsky E, Djanian AY. Serologic studies of myasthenia gravis. Ann N Y Acad Sci. 1965;124:709-729.
46. Aarli JA, Skeie GO, Mygland A, et al. Muscle striation antibodies in myasthenia gravis. Diagnostic and functional significance. Ann N Y Acad Sci. 1998;841:505-515.
47. Kalden JR, Williamson WG, Irvine WJ. Experimental myasthenia gravis, myositis and myocarditis in guinea-pigs immunized with subcellular fractions of calf thymus or calf skeletal muscle in Freund's complete adjuvant. Clin Exp Immunol. 1973;13:79-88.
48. Aarli JA, Flood PR, Gilhus NE, et al. Non-receptor striated muscle antibodies in sera from patients with myasthenia gravis. Monogr Allergy. 1988;25:128-134.
49. Aarli JA. Titin, thymoma, and myasthenia gravis. Arch Neurol. 2001;58:869-870.
50. Mygland A, Aarli JA, Hofstad H, et al. Heart muscle antibodies in myasthenia gravis. Autoimmunity. 1991;10:263-267.
51. Somnier FE, Skeie GO, Aarli JA, et al. EMG evidence of myopathy and the occurrence of titin autoantibodies in patients with myasthenia gravis. Eur J Neurol. 1999;6:555-563.
52. Mygland A, Aarli JA, Matte R, et al. Ryanodine receptor antibodies related to severity of thymoma associated myasthenia gravis. J Neurol Neurosurg Psychiatry. 1994;57:843-846.
53. Romi F, Skeie GO, Aarli JA, et al. The severity of myasthenia gravis correlates with the serum concentration of titin and ryanodine receptor antibodies. Arch Neurol. 2000;57:1596-1600.
54. Mygland A, Vincent A, Newsom-Davis J, et al. Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia. Arch Neurol. 2000;57:527-531.
55. Eng H, Magnusson Y, Matell G, et al. Beta 2-adrenergic receptor antibodies in myasthenia gravis. J Autoimmun. 1992;5:213-227.
56. Xu B, Yi Q, Pirskanen R, et al. Decreased beta2-adrenergic receptor density on peripheral blood mononuclear cells in myasthenia gravis. J Autoimmun. 1997;10:401-406.
57. Xu BY, Pirskanen R, Lefvert AK. Antibodies against beta1 and beta2 adrenergic receptors in myasthenia gravis. J Neuroimmunol. 1998;91:82-88.
58. Magnusson Y, Marullo S, Hoyer S, et al. Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin Invest. 1990;86:1658-1663.
59. Gilbert EM, Olsen SL, Renlund DG, et al. beta-adrenergic receptor regulation and left ventricular function in idiopathic dilated cardiomyopathy. Am J Cardiol. 1993;71:23C-29C.
60. Vernino S, Cheshire WP, Lennon VA. Myasthenia gravis with autoimmune autonomic neuropathy. Anton Neurosci. 2001;88: 187-192.
61. Kornfeld P, Osserman KE. Studies in myasthenia gravis. Evaluation of cardiac conduction. J Mt Sinai Hosp N Y. 1962;29:330-333.
62. Chisholm JC Jr, Gilson A. Rare cardiopulmonary complications of chronically decompensated myasthenia gravis. J Natl Med Assoc. 1980;72:997-998.
63. Wanner WR, Williams TE, Fulkerson PK, et al. Postoperative pericarditis following thymectomy for myasthenia gravis. A prospective study. Chest. 1983;83:647-649.
64. Guillan RA, Zelman S, Smalley RL, et al. Malignant thymoma associated with myasthenia gravis, and evidence of extrathoracic metastases. An analysis of published cases and report of a case. Cancer. 1971;27:823-830.
65. Jaklitsch MT, Byrne JG, Mery C. Thymoma encasing last patent vein graft to the heart. J Thorac Cardiovasc Surg. 1999;118:561-563.