Decreased β2-adrenergic receptor density on peripheral blood mononuclear cells in myasthenia gravis

Journal of Autoimmunity

Volumn 10, Issue 4, 1997, Pages 401-406

  Xu, Bi Ying ^a   Yi, Qing ^a   Pirskanen, Ritva ^a   Matell, George ^a   Eng, Hubert ^a   Lefvert, Ann Kari ^a  

^a STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Autoantibody; Autoimmune disease; Myasthenia gravis; Radioligand binding assay; Receptor; 2 adrenergic

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; AUTOANTIBODY; CYCLIC AMP; IMMUNOGLOBULIN G;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; MONONUCLEAR CELL; MYASTHENIA GRAVIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; SECOND MESSENGER; BLOOD; CASE CONTROL STUDY; DOWN REGULATION; IMMUNOLOGY; KINETICS; METABOLISM; MIDDLE AGED; RADIOASSAY; SKELETAL MUSCLE;

ADULT; AGED; AUTOANTIBODIES; CASE-CONTROL STUDIES; CYCLIC AMP; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOGLOBULIN G; KINETICS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MYASTHENIA GRAVIS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-2; SECOND MESSENGER SYSTEMS;

EID: 0031195503     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1997.0141     Document Type: Article

References (27)

1. Lefvert A.K. Human and experimental myasthenia gravis. Autoimmunity: Physiology and Disease. 1994;Wiley-Liss, Inc. New York.
2. Sundewall A.C., Lefvert A.K. Anti-acetylcholine receptor antibodies in primary biliary cirrhosis. Acta. Med. Scand. 217:1985;519-525.
3. Meyer S.E., Stull J.T. Cyclic AMP in skeletal muscle. Ann. N.Y. Acad. Sci. 185:1971;433-448.
4. Elfellah M.S., Reid J.L. The role of skeletal muscle β-adrenoceptors in the regulation of plasma potassium. J. Auton. Pharmacol. 7:1987;175-184.
5. Marsden C.D., Meadow J.C. The effect of adrenaline on the contraction of muscle. J. Physiol. 207:1970;429-448.
6. Sjogaard G. Water and electrolyte fluxes during exercise and their relation to muscle fatigue. Acta. Physiol. Scand. 128:1986;129-136.
7. Cross R.J., Jackson J.C., Brooks W.H., Sparks D.L., Markesbery W.R., Roszman T.L. Neuroimmunomodulation: impairment of humoral immune responsiveness by 6-hydroxydopamine treatment. Immunology. 57:1986;145-152.
8. Depelchin A., Letesson J.J. Adrenaline influence on the immune response II. Its effects through action on the suppressor T cells. Immunol. Lett. 3:1981;207-213.
9. 2. J. Autoimmun. 5:1992;213-227.
10. 22. Clin. Exp. Immunol. 103:1996;133-140.
11. Brodde O.E. Molecular pharmacology of β-adrenoceptors. J. Cardiovasc. Pharm. Suppl. 4:1986;S16-S20.
12. Oosterhuis H.H.G.H. Studies in myasthenia gravis. Part 1. A clinical study of 180 patients. J. Neurol. Sci. 1:1964;512-546.
13. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. Suppl. 94:1968;21-23.
14. DeBlasi A., Maisel A.S., Feldman R.D., Ziegler M.G., Fratelli M., DiLallo M., Smith D.A., Lai C.-Y.C., Motulsky H.J. In vivo regulation of β-adrenergic receptors on human mononuclear leukocytes: assessment of receptor number, location, and function after posture change, exercise, and isoproterenol infusion. J. Clin. Endocrinol. Metab. 63:1986;847-847.
15. Scatchard G. The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51:1949;660-672.
16. 2. Pharmacotherapy. 14(2):1994;162-172.
17. Magnusson Y., Höyer Y.S., Lengagne R., Chapot M.P., Guillet J.G., Hjalmarson Å., Strosberg A.D., Hoebeke J. Antigenic analysis of the second extra-cellular loop of the human beta-adrenergic receptors. Clin. Exp. Immunol. 78:1989;42-48.
18. 2. Biochemistry. 29:1990;2335-2342.
19. 22. Am. J. Physiol. 258:1990;E1-E1.
20. Aarons R.D., Nies A.S., Gal J., Hegstrand L.R., Molinoff P.B. Elevation of β-adrenergic receptor density in human lymphocytes after propranolol administration. J. Clin. Invest. 65:1980;949-957.
21. Maisel A.S., Motulsky H.J., Insel P.A. Life cycles of cardiac α1- and β-adrenergic receptors. Biochem. Pharmacol. 36(1):1987;1-6.
22. Noji T., Tashiro M., Yagi H., Nagashima K., Suzuki S., Kuroume T. Adaptive regulation of β-adrenergic receptors in children with insulin dependent diabetes mellitus. Horm. Metabol. Res. 18:1986;604-606.
23. 2. Eur. J. Pediatr. 152:1993;797-801.
24. Karaszewski J.W., Reder A.T., Anlar B., Kim W.C., Arnason B.G.W. Increased lymphocyte β-adrenergic receptor density in progressive multiple scherosis is specific for the CD8+, CD28-suppressor cell. Ann. Neurol. 30:1991;42-47.
25. Zoukos Y., Leonard J.P., Thomaides T., Thompson A.J., Cuzner M.L. β-adrenergic receptor density and function of peripheral blood mononuclear cells are increased in multiple sclerosis: a regulatory role for cortisol and interleukin-1. Ann. Neurol. 31:1992;657-662.
26. Baerwald C., Graefe C., von Wichert P., Krause A. Decreased density of β-adrenergic receptors on peripheral blood mononuclear cells in patients with rheumatoid arthritis. J. Rheumatol. 19:1992;204-209.
27. 2. Eur. J. Clin. Invest. 22(Suppl. 1):1992;47-51.