Mechanisms of β-adrenergic receptor-mediated venodilation in humans

Clinical Pharmacology and Therapeutics

Volumn 75, Issue 1, 2004, Pages 49-59

  Schindler, Christoph ^a   Dobrev, Dobromir ^a   Grossmann, Matthias ^a   Francke, Klaus ^a   Pittrow, David ^a   Kirch, Wilhelm ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR; BISOPROLOL; CALCIUM CHANNEL BLOCKING AGENT; GLIBENCLAMIDE; GLYCERYL TRINITRATE; ISOPRENALINE; METHYLENE BLUE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; TETRYLAMMONIUM;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN EXPERIMENT; HYPERPOLARIZATION; MALE; PRIORITY JOURNAL; VEIN DILATATION;

ADRENERGIC BETA-AGONISTS; ADULT; ASPIRIN; BISOPROLOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GLYBURIDE; HAND; HUMANS; ISOPROTERENOL; MALE; METHYLENE BLUE; OMEGA-N-METHYLARGININE; POTASSIUM CHLORIDE; RECEPTORS, ADRENERGIC, BETA-2; TETRAETHYLAMMONIUM; VASODILATION; VEINS;

EID: 1642441405     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clpt.2003.09.009     Document Type: Article

References (51)

1. Eckly A.E., Stoclet J.C., Lugnier C. Isoprenaline induces endothelium-independent relaxation and accumulation of cyclic nucleotides in the rat aorta. Eur J Pharmacol. 271:1994;237-240.
2. Rebich S., Devine J.O., Armstead W.M. Role of nitric oxide and cAMP in beta-adrenoceptor-induced pial artery vasodilation. Am J Physiol. 268:1995;H1071-1076.
3. Vanhoutte P.M. Endothelial adrenoceptors. J Cardiovasc Pharmacol. 38:2001;796-808.
4. Gray D.W., Marshall I. Novel signal transduction pathway mediating endothelium-dependent beta-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol. 107:1992;684-690.
5. Vanhoutte P.M. How to assess endothelial function in human blood vessels. J Hypertens. 17:1999;1047-1058.
6. Kalra P.R., Anagnostopoulos C., Bolger A.P., Coats A.J., Anker S.D. The regulation and measurement of plasma volume in heart failure. J Am Coll Cardiol. 39:2002;1901-1908.
7. Feng Q., Lambert M.L., Callow I.D., Arnold J.M. Venous neuropeptide Y receptor responsiveness in patients with chronic heart failure. Clin Pharmacol Ther. 67:2000;292-298.
8. Aellig W.H. Use of a linear variable differential transformer to measure compliance of human hand veins in situ. [proceedings] Br J Clin Pharmacol. 8:1979;395P.
9. Grossmann M., Dobrev D., Himmel H.M., Kirch W. Local venous response to N-desethylamiodarone in humans. Clin Pharmacol Ther. 67:2000;22-31.
10. Grossmann M., Dobrev D., Siffert W., Kirch W. Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G-protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T) genes but with serum low density lipoprotein cholesterol. Pharmacogenetics. 11:2001;307-316.
11. Schindler C., Grossmann M., Dobrev D., Francke K., Ravens U., Kirch W. Reproducibility of dorsal hand vein responses to phenylephrine and prostaglandin F2 alpha using the dorsal hand vein compliance method. J Clin Pharmacol. 43:2003;228-236.
12. Abdelmawla A.H., Langley R.W., Szabadi E., Bradshaw C.M. Comparison of the effects of nadolol and bisoprolol on the isoprenaline-evoked dilatation of the dorsal hand vein in man. Br J Clin Pharmacol. 51:2001;583-589.
13. Scheller M, Blobner M, Von Loewenich C, Schneck H, Stadler J, Franke C, et al. The NO synthase inhibitors L-Name and L-NMMA, but not L-arginine, block the mammalian nicotinic acetylcholine receptor channel. Toxicol Lett 1998;100-101:109-13.
14. Joannides R., Haefeli W.E., Linder L., Richard V., Bakkali E.H., Thuillez C., et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 91:1995;1314-1319.
15. Vallance P., Collier J., Moncada S. Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo. Cardiovasc Res. 23:1989;1053-1057.
16. Marcelin-Jimenez G., Escalante B. Functional and cellular interactions between nitric oxide and prostacyclin. Comp Biochem Physiol C Toxicol Pharmacol. 129:2001;349-359.
17. Adeagbo A.S., Triggle C.R. Varying extracellular [K+] a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed . J Cardiovasc Pharmacol. 21:1993;423-429.
18. Nishikawa Y., Stepp D.W., Chilian W.M. In vivo location and mechanism of EDHF-mediated vasodilation in canine coronary microcirculation. Am J Physiol. 277:1999;H1252-1259.
19. Gold M.E., Wood K.S., Byrns R.E., Buga G.M., Ignarro L.J. L-arginine-dependent vascular smooth muscle relaxation and cGMP formation. Am J Physiol. 259:1990;H1813-1821.
20. Strobel W.M., Luscher T.F., Simper D., Linder L., Haefeli W.E. Substance P in human hand veins in vivo tolerance, efficacy, potency, and mechanism of venodilator action . Clin Pharmacol Ther. 60:1996;435-443.
21. Pickkers P., Hughes A.D., Russel F.G., Thien T., Smits P. Thiazide-induced vasodilation in humans is mediated by potassium channel activation. Hypertension. 32:1998;1071-1076.
22. Satake N., Fujimoto S., Shibata S. The potentiation of nitroglycerin-induced relaxation by PKG inhibition in rat aortic rings. Gen Pharmacol. 27:1996;701-705.
23. Satake N., Shibata S. Potentiation of the relaxing action of isoproterenol by forskolin in rabbit aortic rings the involvement of beta 2-adrenoceptors . Gen Pharmacol. 28:1997;753-756.
24. Robertson B.E., Schubert R., Hescheler J., Nelson M.T. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol. 265:1993;299-303.
25. Archer S.L., Huang J.M., Hampl V., Nelson D.P., Shultz P.J., Weir E.K. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 91:1994;7583-7587.
26. Cardillo C., Kilcoyne C.M., Quyyumi A.A., Cannon R.O. 3rd, Panza J.A. Decreased vasodilator response to isoproterenol during nitric oxide inhibition in humans. Hypertension. 30:1997;918-921.
27. Dawes M., Chowienczyk P.J., Ritter J.M. Effects of inhibition of the L-arginine/nitric oxide pathway on vasodilation caused by beta-adrenergic agonists in human forearm. Circulation. 95:1997;2293-2297.
28. Nakashima M., Vanhoutte P.M. Isoproterenol causes hyperpolarization through opening of ATP-sensitive potassium channels in vascular smooth muscle of the canine saphenous vein. J Pharmacol Exp Ther. 272:1995;379-384.
29. Ferro A., Queen L.R., Priest R.M., Xu B., Ritter J.M., Poston L., et al. Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol. 126:1999;1872-1880.
30. Yang Z.H., von Segesser L., Bauer E., Stulz P., Turina M., Luscher T.F. Different activation of the endothelial L-arginine and cyclooxygenase pathway in the human internal mammary artery and saphenous vein. Circ Res. 68:1991;52-60.
31. Blackman D.J., Morris-Thurgood J.A., Atherton J.J., Ellis G.R., Anderson R.A., Cockcroft J.R., et al. Endothelium-derived nitric oxide contributes to the regulation of venous tone in humans. Circulation. 101:2000;165-170.
32. Collier J., Vallance P. Biphasic response to acetylcholine in human veins in vivo the role of the endothelium . Clin Sci (Lond). 78:1990;101-104.
33. Ferro A., Kaumann A.J., Brown M.J. Beta 1- and beta 2-adrenoceptor- mediated relaxation in human internal mammary artery and saphenous vein unchanged beta- and alpha-adrenoceptor responsiveness after chronic beta 1-adrenoceptor blockade . Br J Pharmacol. 109:1993;1053-1058.
34. Chalon S., Tejura B., Moreno H. Jr, Urae A., Blaschke T.F., Hoffman B.B. Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins. Br J Clin Pharmacol. 47:1999;91-98.
35. Xiao J., Zhou Z.H., Ye F., Deng H.W., Li Y.J. On the mechanism of the protective effects of nitroglycerin and nicorandil in cardiac anaphylaxis. Naunyn Schmiedebergs Arch Pharmacol. 363:2001;407-413.
36. Nishio E., Watanabe Y. The involvement of reactive oxygen species and arachidonic acid in alpha 1-adrenoceptor-induced smooth muscle cell proliferation and migration. Br J Pharmacol. 121:1997;665-670.
37. Cohen R.A., Plane F., Najibi S., Huk I., Malinski T., Garland C.J. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery. Proc Natl Acad Sci U S A. 94:1997;4193-4198.
38. Pedro M.A., Augusto O., Barbeiro H.V., Carvalho M.H., da-Luz P.L., Laurindo F.R. Nonspecific blockade of vascular free radical signals by methylated arginine analogues. Braz J Med Biol Res. 31:1998;749-755.
39. Zhang Y., Bissing J.W., Xu L., Ryan A.J., Martin S.M., Miller F.J. Jr, et al. Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. J Am Coll Cardiol. 38:2001;546-554.
40. Levi R.C., Alloatti G., Penna C., Gallo M.P. Guanylate-cyclase-mediated inhibition of cardiac ICa by carbachol and sodium nitroprusside. Pflugers Arch. 426:1994;419-426.
41. Koesling D., Friebe A. Soluble guanylyl cyclase structure and regulation . Rev Physiol Biochem Pharmacol. 135:1999;41-65.
42. Ignarro L.J., Fukuto J.M., Griscavage J.M., Rogers N.E., Byrns R.E. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate comparison with enzymatically formed nitric oxide from L-arginine . Proc Natl Acad Sci U S A. 90:1993;8103-8107.
43. Prehn J.L., Bevan J.A. Facial vein of the rabbit. Intracellularly recorded hyperpolarization of smooth muscle cells induced by beta-adrenergic receptor stimulation. Circ Res. 52:1983;465-470.
44. Goto K., Fujii K., Abe I. Impaired beta-adrenergic hyperpolarization in arteries from prehypertensive spontaneously hypertensive rats. Hypertension. 37:2001;609-613.
45. Satake N., Shibata M., Shibata S. The inhibitory effects of iberiotoxin and 4-aminopyridine on the relaxation induced by beta 1- and beta 2-adrenoceptor activation in rat aortic rings. Br J Pharmacol. 119:1996;505-510.
46. van der Zypp A., Kang K.B., Majewski H. Age-related involvement of the endothelium in beta-adrenoceptor-mediated relaxation of rat aorta. Eur J Pharmacol. 397:2000;129-138.
47. von der Weid P.Y. ATP-sensitive K+ channels in smooth muscle cells of guinea-pig mesenteric lymphatics role in nitric oxide and beta-adrenoceptor agonist-induced hyperpolarizations . Br J Pharmacol. 125:1998;17-22.
48. Csont T., Szilvassy Z., Fulop F., Nedeianu S., Pali T., Tosaki A., et al. Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats a cyclic GMP-independent activation of KATP . Br J Pharmacol. 128:1999;1427-1434.
49. Landau R., Dishy V., Wood A.J., Stein C.M., Smiley R.M. Disproportionate decrease in alpha- compared with beta-adrenergic sensitivity in the dorsal hand vein in pregnancy favors vasodilation. Circulation. 106:2002;1116-1120.
50. Simonsen U., Wadsworth R.M., Buus N.H., Mulvany M.J. In vitro simultaneous measurements of relaxation and nitric oxide concentration in rat superior mesenteric artery. J Physiol. 516:1999;271-282.
51. Dishy V., Sofowora G.G., Xie H.G., Kim R.B., Byrne D.W., Stein C.M., et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med. 345:2001;1030-1035.