Design and Analysis of Group Sequential Clinical Trials with Multiple Primary Endpoints

Biometrics

Volumn 60, Issue 1, 2004, Pages 134-145

  Kosorok, Michael R ^a   Shi, Yuanjun ^a   DeMets, David L ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Alpha spending function; Beta spending function; Multivariate outcomes; Sample size; Time to event data

Indexed keywords

CARDIOLOGY; ERRORS; HOSPITALS;

ALPHA-SPENDING FUNCTION; BETA-SPENDING FUNCTION; DESIGN AND ANALYSIS; ERROR RATE; MULTIVARIATE OUTCOME; SAMPLE SIZES; SEQUENTIAL CLINICAL TRIALS; TIME TO EVENTS; TIME-TO-EVENT DATA; TREATMENT EFFECTS;

MEDICAL APPLICATIONS;

EXPERIMENTAL DESIGN; MEDICINE; STATISTICAL ANALYSIS;

ANALYTICAL ERROR; ARTICLE; BIOMETRY; CLINICAL TRIAL; DEATH; DECISION MAKING; HOSPITALIZATION; HUMAN; HYPOTHESIS; MATHEMATICAL ANALYSIS; METHODOLOGY; OUTCOMES RESEARCH; SAMPLING; SIMULATION; TIME;

EID: 1642414943     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2004.00146.x     Document Type: Article

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