Synthesis of 2-Alkylamino-3-fluoropyridines Using Buchwald Conditions

Synthetic Communications

Volumn 34, Issue 5, 2004, Pages 759-766

  Munson, Peter M ^a   Thompson, Wayne J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

2 Alkylamino 3 fluoropyridine; Buchwald conditions; Palladium catalyst; Tetrahydrofuran

Indexed keywords

2 AMINO 3 FLUOROPYRIDINE; 2 CHLORO 3 FLUOROPYRIDINE; FLUORINE DERIVATIVE; PALLADIUM; PYRIDINE DERIVATIVE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 1642387841     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120028348     Document Type: Article

References (5)

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2. de Viedma, A.G.; Martinez-Barrasa, V.; Burgos, C.; Izquierdo, M.L.; Alvarez-Builla, J. N-Azinylpyridinium N-aminides: intermediates for the ragioselective synthesis of 3-fluoro-2-aminopyridine derivatives. J. Org. Chem. 1999, 64, 1007.
3. Sanchez, J.P.; Rogowski, J.W. An efficient synthesis of 6-fluoronalidixic acid and its conversion to enoxacin. J. Heterocycl. Chem. 1987, 24, 215.
4. Wagaw, S.; Buchwald, S.L. The synthesis of aminopyridines: a method employing palladium-catalyzed carbon-nitrogen bond formation. J. Org. Chem. 1996, 61, 7240.
5. Link, W.J.; Borne, R.F.; Setliff, F.L. New 2,3-dinalopyridines. Potential precursors for 2,3-dehydropyridine. J. Heterocycl. Chem. 1967, 4, 641.