A novel RING-finger-like protein Ini1 is essential for cell cycle progression in fission yeast

Journal of Cell Science

Volumn 117, Issue 6, 2004, Pages 967-974

  Oltra, Elisa ^a   Verde, Fulvia ^a   Werner, Rudolf ^a   D'Urso, Gennaro ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Fission yeast; Ini1; Pre mRNA; Ring finger; Wee1

Indexed keywords

CONNEXIN 43; DNA; ESTROGEN; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; PROTEIN INI1; PROTEIN KINASE; RNA PRECURSOR; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL DEATH; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; GENE DELETION; GENETIC ANALYSIS; MITOSIS INHIBITION; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA SPLICING; SCHIZOSACCHAROMYCES POMBE;

AMINO ACID SEQUENCE; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CLONING, MOLECULAR; DNA DAMAGE; DNA REPLICATION; DNA-BINDING PROTEINS; GENES, FUNGAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RNA SPLICING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY, AMINO ACID;

SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 1642386673     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00946     Document Type: Article

References (41)

1. Aubouef, D., Honig, A., Berget, S. M. and O'Malley, B. W. (2002). Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science 298, 416-419.
2. Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A., Ford, J. C., Hoekstra, M. and Carr, A. M. (1996). The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 15, 6641-6651.
3. Bishop, D. T., McDonald, W. H., Gould, K. L. and Forsburg, S. L. (2000). Isolation of an essential Schizosaccharomyces pombe gene, prp31(+), that links splicing and meiosis. Nucleic Acids Res. 28, 2214-2220.
4. Burns, C. G., Ohi, R., Krainer, A. R. and Gould, K. L. (1999). Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 96, 13789-13794.
5. Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K., Markowitz, S. D., Kinzler, K. W. and Vogelstein, B. (1998). Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303.
6. Carr, A. M. and Hoekstra, M. F. (1995). The cellular response to DNA damage. Trends Cell Biol. 5, 32-40.
7. Chen, Z. Q., Lefebvre, D., Bai, X. H., Reaume, A., Rossant, J. and Lye, S. J. (1995). Identification of two regulatory elements within the promoter region of the mouse connexin 43 gene. J. Biol. Chem. 270, 3863-3868.
8. cdc2. Cell 67, 197-211.
9. Goldstrohm, A. C., Greenleaf, A. L. and Garcia-Blanco, M. A. (2001). Co-transcriptional splicing of pre-messenger RNAs: considerations for the mechanism of alternative splicing. Gene 277, 31-47.
10. Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S. et al., (2002). Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nat. Genet. 31, 135-140.
11. Habara, Y., Urushiyama, S., Shibuya, T., Ohshima, Y. and Tani, T. (2001). Mutation in the prp12+ gene encoding a homolog of SAP130/SF3b130 causes differential inhibition of pre-mRNA splicing and arrest of cell-cycle progression in Schizosaccharomyces pombe. Rna 7, 671-681.
12. Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M. and Sakaki, Y. (2001). A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc. Natl. Acad. Sci. USA 98, 4569-4574.
13. Keeney, J. B. and Boeke, J. D. (1994). Efficient Targeted Integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe. Genetics 136, 849-856.
14. Kumagai, A. and Dunphy, W. G. (1991). The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64, 903-914.
15. Lundgren, K., Allan, S., Urushiyama, S., Tani, T., Ohshima, Y., Frendewey, D. and Beach, D. (1996). A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase. Mol. Biol. Cell 7, 1083-1094.
16. Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M. and Beach, D. (1991). mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64, 1111-1122.
17. Maundrell, K. (1993). Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene 123, 127-130.
18. Moreno, S., Klar, A. and Nurse, P. (1991). Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Method. Enzymol. 194, 795-823.
19. Neugebauer, K. M. (2002). On the importance of being co-transcriptional. J. Cell Sci. 115, 3865-3871.
20. Nurse, P. (1975). Genetic control of cell size at cell division in yeast. Nature 256, 547-551.
21. Nurse, P. (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.
22. Ohi, M. D., Link, A. J., Ren, L., Jennings, J. L., McDonald, W. H. and Gould, K. L. (2002). Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol. Cell Biol. 22, 2011-2024.
23. Ohi, R., McCollum, D., Hirani, B., Den Haese, G. J., Zhang, X., Burke, J. D., Turner, K. and Gould, K. L. (1994). The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb. EMBO J. 13, 471-483.
24. Oltra, E., Pfeifer, I. and Werner, R. (2003). Ini, a small nuclear protein that enhances the response of the connexin43 gene to estrogen. Endocrinology 144, 3148-3158.
25. Oltra, E. and Werner, R. (1998). Cloning of a potential regulatory protein involved in Connexin43 gene expression. Amsterdam: IOS Press.
26. cdc2 on tyrosine 15. Proc. Natl. Acad. Sci. USA 89, 2917-2921.
27. cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257, 1955-1957.
28. Potashkin, J., Kim, D., Fons, M., Humphrey, T. and Frendewey, D. (1998). Cell-division-cycle defects associated with fission yeast pre-mRNA splicing mutants. Curr. Genet. 34, 153-163.
29. Potashkin, J., Li, R. and Frendewey, D. (1989). Pre-mRNA splicing mutants of Schizosaccharomyces pombe. EMBO J. 8, 551-559.
30. Raleigh, J. M. and O'Connell, M. J. (2000). The G(2) DNA damage checkpoint targets both Wee1 and Cdc25. J. Cell Sci. 113, 1727-1736.
31. Russell, P. and Nurse, P. (1986). cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell 45, 145-153.
32. Russell, P. and Nurse, P. (1987). Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 49, 559-567.
33. Sazer, S. and Sherwood, S. W. (1990). Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast. J. Cell Sci. 97, 509-516.
34. Schmitt, M. E., Brown, T. A. and Trumpower, B. L. (1990). A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucleic Acids Res. 18, 3091-3092.
35. Sebastian, B., Kakizuka, A. and Hunter, T. (1993). Cdc25 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine- 15. Proc. Natl. Acad. Sci. USA 90, 3521-3524.
36. Shimoseki, M. and Shimoda, C. (2001). The 5′ terminal region of the Schizosaccharomyces pombe mes1 mRNA is crucial for its meiosis-specific splicing. Mol. Genet. Genomics 265, 673-682.
37. Strausfeld, U., Labbé, J.-C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P. and Dorée, M. (1991). Dephophorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature 351, 242-245.
38. Trappe, R., Schulze, E., Rzymski, T., Frode, S. and Engel, W. (2002). The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development. Biochem. Biophys. Res. Commun. 297, 1049-1057.
39. Urushiyama, S., Tani, T. and Ohshima, Y. (1996). Isolation of novel pre-mRNA splicing mutants of Schizosaccharomyces pombe. Mol. Gen. Genet. 253, 118-127.
40. Will, C. L., Urlaub, H., Achsel, T., Gentzel, M., Wilm, M. and Luhrmann, R. (2002). Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J. 21, 4978-4988.
41. Zhao, Y., Goto, K., Saitoh, M., Yanase, T., Nomura, M., Okabe, T., Takayanagi, R. and Nawata, H. (2002). Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor. J. Biol. Chem. 277, 30031-30039.