Induction of opsonic antibodies to the γ-D-glutamic acid capsule of Bacillus anthracis by immunization with a synthetic peptide-carrier protein conjugate

FEMS Immunology and Medical Microbiology

Volumn 40, Issue 3, 2004, Pages 231-237

  Wang, Taia T ^a   Fellows, Patricia F ^b   Leighton, Terrance J ^a   Lucas, Alexander H ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Antibodies; Bacillus anthracis; Capsule; Poly D glutamic acid

Indexed keywords

ANTHRAX VACCINE; DEXTRO GLUTAMIC ACID; EPITOPE; GAMMA DEXTRO GLUTAMIC ACID NONAMER PEPTIDE; IMMUNOGLOBULIN G ANTIBODY; KEYHOLE LIMPET HEMOCYANIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL CELL; BACTERIAL MEMBRANE; CELL ENCAPSULATION; CONJUGATE; CONTROLLED STUDY; COVALENT BOND; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN INDUCTION;

ANIMALS; ANTHRAX VACCINES; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL CAPSULES; CARRIER PROTEINS; EPITOPES; HEMOCYANIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MICE; MICE, INBRED BALB C; OPSONIN PROTEINS; PHAGOCYTOSIS; POLYGLUTAMIC ACID; VACCINATION; VACCINES, CONJUGATE;

EID: 1642375741     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(03)00366-3     Document Type: Article

References (21)

1. Dixon T.C., Meselson M., Guillemin J., Hanna P.C. Anthrax. N. Engl. J. Med. 341:1999;815-826.
2. Mock M., Fouet A. Anthrax. Annu. Rev. Microbiol. 55:2001;647-671.
3. Hanby W.E., Rydon H.N. The capsule substance of Bacillus anthracis. Biochem. J. 40:1946;297-309.
4. Makino S.-I., Uchida I., Terakado N., Sasakawa C., Yoshikawa M. Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis. J. Bacteriol. 171:1989;722-729.
5. Turnbull P.C.B. Anthrax vaccines: past, present and future. Vaccine. 9:1991;533-539.
6. Leppla S.H., Robbins J.B., Schneerson R., Shiloach J. Development of improved vaccine for anthrax. J. Clin. Invest. 110:2002;141-144.
7. Brossier F., Levy M., Mock M. Anthrax spores make an essential contribution to vaccine efficacy. Infect. Immun. 70:2002;661-664.
8. Goodman J.W., Nitecki D.E. Studies on the relation of a prior immune response to immunogenicity. Immunology. 13:1967;577-583.
9. Maurer P.H. Antigenicity of polypeptides (poly alpha amino acids). XII. Immunological studies with synthetic polymers containing only D- or D- and L-α amino acids. J. Exp. Med. 121:1965;339-349.
10. Robbins J.B., Schneerson R., Anderson P., Simth D.H. The 1996 Albert Lasker Medical Research Awards, Prevention of systemic infections, especially meningitis, caused by Haemophilus influenzae type b. Impact on public health and implications for other polysaccharide-based vaccines. J. Am. Med. Assoc. 276:1996;1181-1185.
11. Leonard C.G., Housewright R.D., Thorne C.B. Effects of metallic ions on glutamyl polypeptide synthesis by Bacillus anthracis. J. Bacteriol. 76:1958;499-503.
12. Yoon S.H., Do J.H., Lee S.Y., Chang H.N. Production of poly-γ-glutamic acid feD-batch culture of Bacillus licheniformis. Biotechnol. Lett. 22:2000;585-588.
13. Jansen W.T.M., Gootjes J., Zelle M., Madore D.V., Verhoef J., Snippe H., Verheul A.F.M. Use of highly encapsulated Streptococcus pneumoniae strains in a flow cytometry assay for assessment of the phagocytic capacity of serotype-specific antibodies. Clin. Diagn. Lab. Immunol. 5:1998;703-710.
14. Ashiuchi M., Misono H. Biochemistry and molecular genetics of poly-γ-glutamate synthesis. Appl. Microbiol. Biotechnol. 59:2002;9-14.
15. Goodman J.W., Nitecki D.E., Stoltenberg I.M. Immunochemical studies on the poly-γ-D-glutamyl capsule of Bacillus anthracis. III. The activity with rabbit antisera of peptides derived from the homologous polypeptide. Biochemistry. 7:1968;706-710.
16. Schneerson R., Kubler-Kielb J., Liu T.-Y., Dai Z.-D., Leppla S.H., Yergey A., Backlund P., Shiloach J., Majadly F., Robbins J.B. Poly(γ-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine. Proc. Nat. Acad. Sci. USA. 100:2003;8945-8950.
17. Rhie G.-E., Roehrl M.H., Mourez M., Collier R.J., Mekalanos J.J., Wang J.Y. A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc. Nat. Acad. Sci. USA. 100:2003;10925-10930.
18. Borio L., et al. Death due to bioterrorism-related inhalational anthrax. J. Am. Med. Assoc. 286:2001;2554-2559.
19. Grinberg L.M., et al. Quantitative pathology of inhalational anthrax I: quantative microscopic findings. Mod. Pathol. 14:2001;482-495.
20. Anderson G.G., et al. Intracellular bacterial biofilm-like pods in urinary tract infections. Science. 301:2003;105-107.
21. Parsek M.R., Singh P.K. Bacterial biofilms: an emerging link to disease pathogenesis. Annu. Rev. Microbiol. 57:2003;677-701.