Solid-Phase Synthesis of Positively Charged Deoxynucleic Guanidine (DNG) Tethering a Hoechst 33258 Analogue: Triplex and Duplex Stabilization by Simultaneous Minor Groove Binding

Journal of the American Chemical Society

Volumn 126, Issue 12, 2004, Pages 3736-3747

  Reddy, Putta Mallikarjuna ^a   Bruice, Thomas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DNA; FLUORESCENCE; MOLECULAR STRUCTURE; PH EFFECTS;

SOLID-PHASE SYNTHESIS;

GENETIC ENGINEERING;

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; AMINO ACID; DEOXYNUCLEIC GUANIDINE; DOUBLE STRANDED DNA; GUANIDINE DERIVATIVE; SINGLE STRANDED DNA; THYMIDINE DEOXYNUCLEIC GUANIDINE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; AT RICH SEQUENCE; BASE MISPAIRING; BINDING SITE; CONJUGATE; DNA BINDING; DNA DRUG COMPLEX; FLUORESCENCE; MELTING POINT; MOLECULAR STABILITY; PH; SOLID; SOLID PHASE SYNTHESIS; SYNTHESIS;

BASE SEQUENCE; BISBENZIMIDE; DNA; DRUG STABILITY; GUANIDINES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 1642374335     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja031557s     Document Type: Article

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