A Molecular Elevator

Science

Volumn 303, Issue 5665, 2004, Pages 1845-1849

  Bacljić, Jovica D ^a   Balzani, Vincenzo ^b   Credi, Alberto ^b   Silvi, Serena ^b   Stoddart, J Fraser ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHARACTERIZATION; NANOTECHNOLOGY; SYNTHESIS (CHEMICAL);

MOLECULAR MACHINES; NANOSCALE ELEVATORS;

MOLECULAR DYNAMICS;

NANOPARTICLE;

NANOTECHNOLOGY;

ARTICLE; COMPLEX FORMATION; CYCLIC POTENTIOMETRY; DEVICE; MACROMOLECULE; MOLECULAR EVOLUTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 1642362624     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094791     Document Type: Article

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24. Although multivalency is a concept that is well-established with regard to numerous biological systems, its investigation has been restricted largely to the acquisition of thermodynamic parameters, e.g., association or dissociation constants and free energies, enthalpies, and entropies of complexation. In the present investigation, the opportunity arose to study within a molecularly constrained environment how three equivalent recognition sites respond to being addressed chemically. The fact that they switch in series rather than in parallel is a feature worthy of note. Although many might argue intuitively that multivalency from a mechanistic standpoint has to be a stepwise process, the results presented in this article provide indirect yet convincing experimental evidence for the one-at-a-time mechanism; i.e., by taking single steps rather than moving in concert, the molecular elevator is more reminiscent of a legged animal than it is of the passenger elevator.
25. This research was supported by NSF (CHE-0317170, CHE-9974928, and CHE-0116853) in the United States and the University of Bologna (Funds for selected topics), Ministero dell'Istruzione, dell'Università e della Ricerca (Supramolecular devices project), Fondo per gli Investimenti della Ricerca di Base (RBNE019H9K) and the European Union (Molecular-Level Devices and Machines Network HPRN-CT-2000-00029) in Italy. We thank M. Venturi and P. Ceroni for useful discussions.