Dysregulation of Hypoxia Inducible Factor-1α Head and Neck Squamous Cell Carcinoma Cell Lines Correlates with Invasive Potential

Laryngoscope

Volumn 114, Issue 3, 2004, Pages 418-423

  Cohen, Noam A ^a   Lai, Stephen Y ^a   Ziober, Amy F ^a   Ziober, Barry L ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypoxia inducible factor 1 ; Invasion; Tumorigenesis

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CANCER RADIOTHERAPY; CARCINOGENESIS; CONTROLLED STUDY; ERYTHROPOIESIS; GENE MUTATION; GLYCOLYSIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HYPOXIA; MALIGNANT TRANSFORMATION; NEOVASCULARIZATION (PATHOLOGY); ONCOGENE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL HYPOXIA; CELL LINE; HEAD AND NECK NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM INVASIVENESS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 1642361242     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200403000-00006     Document Type: Article

References (28)

1. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene. Proc Natl Acad Sci U S A 1991;88:5680-5684.
2. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-5454.
3. Wang GL, Semenza, GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513-21518.
4. Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor. J Biol Chem 1995;270:1230-1237.
5. 2 tension. Proc Natl Acad Sci U S A 1995;92:5510-5514.
6. Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-78.
7. Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, FujiiKuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A 1997;94:4273-4278.
8. Flamme I, Frolich T, vonReutern M, Kappel A, Damert A, Risau W, HRF: a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev 1997;63:51-60.
9. Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3α. Gene Exp 1998;7:205-213.
10. 2-regulated prolyl hydroxylation. Science 2001;292:468-472.
11. Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor la by the ubiquitin-proteasome pathway. J Biol Chem 1999;274:6519-6525.
12. Warburg OH. In: Dickens, F, trans. The Metabolism of Tumours. London: Constable; 1930:11-25.
13. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-364.
14. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities for cancer therapy. Cancer Res 1998;58:1408-1416.
15. Dachs GU, Patterson AV, Firth JD, et al. Targeting gene expression to hypoxic tumor cells. Nat Med 1997;3:515-520.
16. Talks KT, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers and tumor-associated macrophages. Am J Pathol 2000;157:411-421.
17. Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1 alpha in brain tumors Cancer 2000;88:2606-2618.
18. Zhong H, Agani F, Baccala AA, et al. Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer. Cancer Res 1998;58:5280-5284.
19. Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-2916.
20. Ziober BL, Chen YQ, Ramos DM, Waleh N, Kramer RH. Expression of the α7β1 laminin receptor suppresses melanoma growth and metastatic potential. Cell Growth Diff 1999;10:479-490.
21. Semenza GL. Signal transduction to hypoxia-inducible factor-1. Biochem Pharm 2002;64:993-998.
22. Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002;277:23111-23115.
23. Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT. EMBO J 1998;17:5085-5094.
24. Hellwig-Burgel T, Rutkowski K, Metzen E, Fandrey J, Jelkmann W. Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1. Blood 1999;94:1561-1567.
25. Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000;27:26765-26771.
26. Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, et al. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: role of the p22(phox)-containing NADPH oxidase. Circ Res 2001;89:47-54.
27. Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-1545.
28. Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T. Normoxic induction of hypoxia-inducible factor 1α by insulin interleukin-1β involves the phosphatidylinositol 3-kinase pathway FEBS Lett 2002;512:157-162.