Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes

Cardiovascular Research

Volumn 59, Issue 4, 2003, Pages 854-862

  Lyngdorf, L G ^a   Gregersen, S ^a   Daugherty, A ^b   Falk, E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Apolipoprotein E deficient mice; Atherosclerosis; Food restriction; Gold thioglucose; Insulin resistance; Obesity; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN E; AUROTHIOGLUCOSE; SODIUM CHLORIDE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DISEASE COURSE; EXPERIMENTAL MODEL; FEMALE; FOOD; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LEAN BODY WEIGHT; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; STARVATION;

ANIMALS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; AUROTHIOGLUCOSE; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; FEMALE; FOOD DEPRIVATION; INSULIN; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MYOCARDIUM; OBESITY; TIME FACTORS; TRIGLYCERIDES; WEIGHT GAIN;

EID: 1642347935     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00506-6     Document Type: Article

References (34)

1. Grundy S.M., Benjamin I.J., Burke G.L., et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 100:1999;1134-1146.
2. Gerstein H.C., Yusuf S. Dysglycaemia and risk of cardiovascular disease. Lancet. 347:1996;949-950.
3. Stamler J., Caggiula A., Grandits G.A., Kjelsberg M., Cutler J.A. Relationship to blood pressure of combinations of dietary macronutrients. Findings of the Multiple Risk Factor Intervention Trial (MRFIT). Circulation. 94:1996;2417-2423.
4. Assmann G., Schulte H. The Prospective Cardiovascular Munster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J. 116:1998;1713-1724.
5. Nakashima Y., Plump A.S., Raines E.W., Breslow J.L., Ross R. ApoE-deficient mice develop lesions of all phases of the atherosclerosis throughout the arterial tree. Arterioscler Thromb. 14:1994;133-140.
6. Le Marchand-Brustel Y. Molecular mechanisms of insulin action in normal and insulin-resistant states. Exp Clin Endocrinol Diabetes. 107:1999;126-132.
7. Daugherty A., Manning M.W., Cassis L.A. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest. 105:2000;1605-1612.
8. Paigen B., Morrow A., Holmes P.A., Mitchell D., Williams R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 68:1987;231-240.
9. Maffei M., Fei H., Lee G.H., et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA. 92:1995;6957-6960.
10. Blair S.C., Caterson I.D., Cooney G.J. Insulin response to a spontaneously ingested standard meal during the development of obesity in GTG-injected mice. Int J Obes Relat Metab Disord. 20:1996;319-323.
11. Fei H., Okano H.J., Li C., et al. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA. 94:1997;7001-7005.
12. Steinbeck K., Caterson I.D., Turtle J.R. The activity of the pyruvate dehydrogenase complex in heart muscle in the previously obese mouse model. Biosci Rep. 6:1986;1071-1075.
13. Hirano T., Takahashi T., Saito S., et al. Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E. Am J Physiol Endocrinol Metab. 281:2001;E665-E669.
14. Schreyer S.A., Vick C., Lystig T.C., Mystkowski P., Leboeuf R.C. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab. 282:2002;E207-E214.
15. Bergen H.T., Monkman N., Mobbs C.V. Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight. Brain Res. 734:1996;332-336.
16. Zhang S.H., Reddick R.L., Piedrahita J.A., Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 258:1992;468-471.
17. Dansky H.M., Charlton S.A., Sikes J.L., et al. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 19:1999;1960-1968.
18. Surwit R.S., Kuhn C.M., Cochrane C., McCubbin J.A., Feinglos M.N. Diet-induced type II diabetes in C57BL/6J mice. Diabetes. 37:1988;1163-1167.
19. Ahren B., Simonsson E., Scheurink A.J., et al. Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice. Metabolism. 46:1997;97-106.
20. West D.B., Boozer C.N., Moody D.L., Atkinson R.L. Dietary obesity in nine inbred mouse strains. Am J Physiol. 262:1992;R1025-R1032.
21. Nishina P.M., Naggert J.K., Verstuyft J., Paigen B. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism. 43:1994;554-558.
22. Merat S., Casanada F., Sutphin M., Palinski W., Reaven P.D. Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arterioscler Thromb Vasc Biol. 19:1999;1223-1230.
23. Russell J.C., Graham S.E., Richardson M. Cardiovascular disease in the JCR:LA-cp rat. Mol Cell Biochem. 188:1998;113-126.
24. Veniant M.M., Sullivan M.A., Kim S.K., et al. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest. 106:2000;1501-1510.
25. Nordestgaard B.G., Stender S., Kjeldsen K. Reduced atherogenesis in cholesterol-fed diabetic rabbits. Giant lipoproteins do not enter the arterial wall. Arteriosclerosis. 8:1988;421-428.
26. 1 mice. Mohr U., Dungworth D.L., Capen C.C., Carlton W.W., Sundberg J.P., Ward S.M. Pathobiology of the Aging Mouse. vol. 1:1996;21-26 ILSI Press, Washington.
27. Gresham G.A. Is atheroma a reversible lesion? Atherosclerosis. 23:1976;379-391.
28. Reckless J., Metcalfe J.C., Grainger D.J. Tamoxifen decreases cholesterol sevenfold and abolishes lipid lesion development in apolipoprotein E knockout mice. Circulation. 95:1997;1542-1548.
29. Tangirala R.K., Casanada F., Miller E., et al. Effect of the antioxidant N,N′ -diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice. Arterioscler Thromb Vasc Biol. 15:1995;1625-1630.
30. Smith J.D., Trogan E., Ginsberg M., et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci USA. 92:1995;8264-8268.
31. Guo Z., Mitchell-Raymundo F., Yang H., et al. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev. 123:2002;1121-1131.
32. Ravn H.B., Korsholm T.L., Falk E. Oral magnesium supplementation induces favorable antiatherogenic changes in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 21:2001;858-862.
33. Tangirala R.K., Rubin E.M., Palinski W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res. 36:1995;2320-2328.
34. Matsuo T., Shino A. Induction of diabetic alterations by goldthioglucose-obesity in KK, ICR and C57BL mice. Diabetologia. 8:1972;391-397.