메뉴 건너뛰기




Volumn 103, Issue 7, 2004, Pages 2617-2623

In vivo neutralization of a C2 domain-specific human anti-Factor VIII inhibitor by an anti-idiotypic antibody

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8 INHIBITOR; IDIOTYPIC ANTIBODY; LEUCINE; METHIONINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B14C12; MONOCLONAL ANTIBODY BO2C11; NEUTRALIZING ANTIBODY; PHENYLALANINE; RECOMBINANT BLOOD CLOTTING FACTOR 8; UNCLASSIFIED DRUG;

EID: 1642324071     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-07-2207     Document Type: Article
Times cited : (33)

References (35)
  • 1
    • 85085673263 scopus 로고
    • A meta-analysis based on eight long-term followup studies concerning inhibitors associated with crude or intermediate purity FVIII products
    • Briët E, Rosendaal FR, Kreuz W. A meta-analysis based on eight long-term followup studies concerning inhibitors associated with crude or intermediate purity FVIII products. Throm Haemost. 1994;72:162-164.
    • (1994) Throm Haemost , vol.72 , pp. 162-164
    • Briët, E.1    Rosendaal, F.R.2    Kreuz, W.3
  • 2
    • 0026548917 scopus 로고
    • Incidence of FVIII and FIX inhibitors in hemophiliacs
    • Ehrenforth S, Kreuz W, Sharrer I, et al. Incidence of FVIII and FIX inhibitors in hemophiliacs [letter]. Lancet. 1992;339:594.
    • (1992) Lancet , vol.339 , pp. 594
    • Ehrenforth, S.1    Kreuz, W.2    Sharrer, I.3
  • 3
    • 0035194439 scopus 로고    scopus 로고
    • Recombinant factor VIIa (Novoseven) as a hemostatic agent
    • Hedner U. Recombinant factor VIIa (Novoseven) as a hemostatic agent. Semin Hematol. 2001;38(suppl 12):43-47.
    • (2001) Semin Hematol , vol.38 , Issue.SUPPL. 12 , pp. 43-47
    • Hedner, U.1
  • 4
  • 5
    • 0027050152 scopus 로고
    • Epitope mapping of human factor VIII inhibitor antibodies by site-directed mutagenesis of a factor VIII polypeptide
    • Ware J, MacDonald M, Lo M, de Graaf S, Fulcher C. Epitope mapping of human factor VIII inhibitor antibodies by site-directed mutagenesis of a factor VIII polypeptide. Blood Coagul Fibrinolysis. 1992;3:703-716.
    • (1992) Blood Coagul Fibrinolysis , vol.3 , pp. 703-716
    • Ware, J.1    MacDonald, M.2    Lo, M.3    De Graaf, S.4    Fulcher, C.5
  • 6
    • 0028307976 scopus 로고
    • Factor VIII inhibitors: Structure and function in autoantibody and hemophilia A patients
    • Hoyer L, Scandella D. Factor VIII inhibitors: structure and function in autoantibody and hemophilia A patients. Semin Hematol. 1994;31(2 Suppl 4):1-5.
    • (1994) Semin Hematol , vol.31 , Issue.2 SUPPL. 4 , pp. 1-5
    • Hoyer, L.1    Scandella, D.2
  • 7
    • 0032528496 scopus 로고    scopus 로고
    • Mechanisms and kinetics of FVIII inactivation: Study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor
    • Jacquemin M, Desqueper B, Benhida A, et al. Mechanisms and kinetics of FVIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor. Blood. 1998;92:496-501.
    • (1998) Blood , vol.92 , pp. 496-501
    • Jacquemin, M.1    Desqueper, B.2    Benhida, A.3
  • 8
    • 0035412387 scopus 로고    scopus 로고
    • Structure of FVIII C2 domain-immunoglobulin G4kappa Fab complex: Identification of an inhibitory antibody epitope on the surface of FVIII
    • Spiegel P, Jacquemin M, Saint-Remy JM, Stoddard B, Pratt K. Structure of FVIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of FVIII. Blood. 2001;98:13-19.
    • (2001) Blood , vol.98 , pp. 13-19
    • Spiegel, P.1    Jacquemin, M.2    Saint-Remy, J.M.3    Stoddard, B.4    Pratt, K.5
  • 10
    • 0027938488 scopus 로고
    • Healthy subjects produce both anti-factor VIII and specific anti-idiotypic
    • Gilles JG, Saint-Remy JM. Healthy subjects produce both anti-factor VIII and specific anti-idiotypic. J Clin Invest. 1994;94:1496-1505.
    • (1994) J Clin Invest , vol.94 , pp. 1496-1505
    • Gilles, J.G.1    Saint-Remy, J.M.2
  • 11
    • 0029920320 scopus 로고    scopus 로고
    • Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A
    • Gilles JG, Desqueper B, Lenk H, Vermylen J, Saint-Remy JM. Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A. J Clin Invest. 1996;97:1382-1388.
    • (1996) J Clin Invest , vol.97 , pp. 1382-1388
    • Gilles, J.G.1    Desqueper, B.2    Lenk, H.3    Vermylen, J.4    Saint-Remy, J.M.5
  • 12
    • 0030584423 scopus 로고    scopus 로고
    • Tolerance to factor VIII inhibitors in hemophilia a patients: A French twist
    • Pascual V, Capra J. Tolerance to factor VIII inhibitors in hemophilia a patients: a French twist. J Clin Invest. 1996;97:1357-1358.
    • (1996) J Clin Invest , vol.97 , pp. 1357-1358
    • Pascual, V.1    Capra, J.2
  • 13
    • 0027488655 scopus 로고
    • Anti-FVIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotopic restriction
    • Gilles JG, Arnout J, Vermylen J, Saint-Remy JM. Anti-FVIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotopic restriction. Blood. 1993;82:2452-2461.
    • (1993) Blood , vol.82 , pp. 2452-2461
    • Gilles, J.G.1    Arnout, J.2    Vermylen, J.3    Saint-Remy, J.M.4
  • 14
    • 0037089416 scopus 로고    scopus 로고
    • Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII
    • van den Brink E, Bril W, Turenhout E, et al. Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. Blood. 2002;99:2828-2834.
    • (2002) Blood , vol.99 , pp. 2828-2834
    • Van Den Brink, E.1    Bril, W.2    Turenhout, E.3
  • 15
    • 0033962015 scopus 로고    scopus 로고
    • A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor
    • Jacquemin M, Benhida A, Peerlinck K, et al. A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor. Blood. 2000;95:156-163.
    • (2000) Blood , vol.95 , pp. 156-163
    • Jacquemin, M.1    Benhida, A.2    Peerlinck, K.3
  • 16
    • 0024844388 scopus 로고
    • Conformations of immunoglobulin hypervariable regions
    • Chothia C, Lesk AM, Tramontano A, et al. Conformations of immunoglobulin hypervariable regions. Nature. 1989;342:877-883.
    • (1989) Nature , vol.342 , pp. 877-883
    • Chothia, C.1    Lesk, A.M.2    Tramontano, A.3
  • 17
    • 0021097529 scopus 로고
    • How good are predictions of protein secondary structure?
    • Kabsch W, Sander C. How good are predictions of protein secondary structure? FEBS Lett. 1983;155:179-182.
    • (1983) FEBS Lett , vol.155 , pp. 179-182
    • Kabsch, W.1    Sander, C.2
  • 18
    • 0023984847 scopus 로고
    • Optimal alignments in linear space
    • Myers E, Miller W. Optimal alignments in linear space. Comput Appl Biosci. 1988;4:11-17.
    • (1988) Comput Appl Biosci , vol.4 , pp. 11-17
    • Myers, E.1    Miller, W.2
  • 19
  • 20
    • 0037178807 scopus 로고    scopus 로고
    • Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8
    • Villard S, Piquer D, Raut S, Leonetti JP, Saint-Remy JM, Granier C. Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8. J Biol Chem. 2002;277:232-239.
    • (2002) J Biol Chem , vol.277 , pp. 232-239
    • Villard, S.1    Piquer, D.2    Raut, S.3    Leonetti, J.P.4    Saint-Remy, J.M.5    Granier, C.6
  • 21
    • 0036565867 scopus 로고    scopus 로고
    • Anti-thrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model
    • Singh I, Smith A, Vanzieleghem B, et al. Anti-thrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model. Blood. 2002;99:3235-3240.
    • (2002) Blood , vol.99 , pp. 3235-3240
    • Singh, I.1    Smith, A.2    Vanzieleghem, B.3
  • 22
    • 9144271163 scopus 로고    scopus 로고
    • Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development
    • d'Oiron R, Lavergne J.-M., Lavend'homme R, et al. Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. Blood. 2004;103:155-157.
    • (2004) Blood , vol.103 , pp. 155-157
    • D'Oiron, R.1    Lavergne, J.-M.2    Lavend'homme, R.3
  • 23
    • 0033621486 scopus 로고    scopus 로고
    • Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism
    • Saenko E, Yakhyaev A, Mikhailenko I, Strickland D, Sarafanov A. Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism. J Biol Chem. 1999;274:37685-37692.
    • (1999) J Biol Chem , vol.274 , pp. 37685-37692
    • Saenko, E.1    Yakhyaev, A.2    Mikhailenko, I.3    Strickland, D.4    Sarafanov, A.5
  • 24
    • 0033588163 scopus 로고    scopus 로고
    • The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein
    • Lenting P, Neels J, van den Berg B, et al. The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein. J Biol Chem. 1999;274:23734-23739.
    • (1999) J Biol Chem , vol.274 , pp. 23734-23739
    • Lenting, P.1    Neels, J.2    Van Den Berg, B.3
  • 25
    • 0037235949 scopus 로고    scopus 로고
    • Engineered antibodies
    • Hudson P, Souriau C. Engineered antibodies. Nat Med. 2003;9:129-134.
    • (2003) Nat Med , vol.9 , pp. 129-134
    • Hudson, P.1    Souriau, C.2
  • 26
    • 0036263042 scopus 로고    scopus 로고
    • New insights into the binding interfaces of coagulation factors V and VIII and their homologues: Lessons from high resolution crystal structures
    • Fuentes-Prior P, Fujikawa K, Pratt K. New insights into the binding interfaces of coagulation factors V and VIII and their homologues: lessons from high resolution crystal structures. Curr Protein Pept Sci. 2002;3:313-339.
    • (2002) Curr Protein Pept Sci , vol.3 , pp. 313-339
    • Fuentes-Prior, P.1    Fujikawa, K.2    Pratt, K.3
  • 27
    • 0023274159 scopus 로고
    • FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting
    • Fulcher C, de Graaf Mahoney S, Zimmerman T. FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood. 1987;69:1475-1480.
    • (1987) Blood , vol.69 , pp. 1475-1480
    • Fulcher, C.1    De Graaf Mahoney, S.2    Zimmerman, T.3
  • 28
    • 0035278835 scopus 로고    scopus 로고
    • In hemophilia A and autoantibody inhibitor patients: The factor VIII A2 domain and light chain are most immunogenic
    • Scandella DH, Nakai H, Felch M, et al. In hemophilia A and autoantibody inhibitor patients: the factor VIII A2 domain and light chain are most immunogenic. Thromb Res. 2001;101:377-385.
    • (2001) Thromb Res , vol.101 , pp. 377-385
    • Scandella, D.H.1    Nakai, H.2    Felch, M.3
  • 29
    • 0033923626 scopus 로고    scopus 로고
    • Phage display technology: A tool to explore the diversity of inhibitors to blood coagulation factor VIII
    • Voorberg J, van den Brink EN. Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII. Semin Thromb Hemost. 2000;26:143-150.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 143-150
    • Voorberg, J.1    Van Den Brink, E.N.2
  • 30
    • 0029998402 scopus 로고    scopus 로고
    • Recommendations for the treatment of factor VIII inhibitors: From the UK Haemophilia Centre Directors' Organisation Inhibitor Working Party
    • Hay C, Colvin B, Ludlam CA, Hill F, Preston F. Recommendations for the treatment of factor VIII inhibitors: from the UK Haemophilia Centre Directors' Organisation Inhibitor Working Party. Blood Coagul Fibrinolysis. 1996;7:134-138.
    • (1996) Blood Coagul Fibrinolysis , vol.7 , pp. 134-138
    • Hay, C.1    Colvin, B.2    Ludlam, C.A.3    Hill, F.4    Preston, F.5
  • 32
    • 0036493712 scopus 로고    scopus 로고
    • Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: Clinical and immune responses in 35 patients
    • Timmerman J, Debra K, Czerwinski D, et al. Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood. 2002;99:1517-1526.
    • (2002) Blood , vol.99 , pp. 1517-1526
    • Timmerman, J.1    Debra, K.2    Czerwinski, D.3
  • 33
    • 0028127935 scopus 로고
    • Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein
    • Vuist W, Levy R, Maloney D. Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein. Blood. 1994;83:899-906.
    • (1994) Blood , vol.83 , pp. 899-906
    • Vuist, W.1    Levy, R.2    Maloney, D.3
  • 34
    • 0025276998 scopus 로고
    • Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells
    • Benhamou L, Cazenave P, Sarthou P. Anti-immunoglobulins induce death by apoptosis in WEHI-231 B lymphoma cells. Eur J Immunol. 1990;20:1405-1407.
    • (1990) Eur J Immunol , vol.20 , pp. 1405-1407
    • Benhamou, L.1    Cazenave, P.2    Sarthou, P.3
  • 35
    • 0035205962 scopus 로고    scopus 로고
    • Ig-binding receptors on human NK cells as effector and regulatory surface molecules
    • Sulica A, Morel P, Metes D, Herberman R. Ig-binding receptors on human NK cells as effector and regulatory surface molecules. Int Rev Immunol. 2001;20:371-414.
    • (2001) Int Rev Immunol , vol.20 , pp. 371-414
    • Sulica, A.1    Morel, P.2    Metes, D.3    Herberman, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.