Is acne really a disease?: A theory of acne as an evolutionarily significant, high-order psychoneuroimmune interaction timed to cortical development with a crucial role in mate choice

Medical Hypotheses

Volumn 62, Issue 3, 2004, Pages 462-469

  Bloom, Dale F ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACNE; BRAIN DEVELOPMENT; EVOLUTION; HUMAN; HUMAN RELATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; REPRODUCTION; REVIEW; SEXUAL SELECTION;

EID: 1642310999     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.11.003     Document Type: Article

References (59)

1. Perrett DI, May KA, Yoshikawa S. Facial shape and judgments of female attractiveness. Nature 1994;386:239-42.
2. Miller GF. How mate choice shaped human nature: A review of sexual selection and human evolution. In: Crawford C, Krebs D, editors. Handbook of evolutionary psychology: Ideas, issues, and applications. Lawrence Erlbaum; 1998. p. 87-129.
3. Singh D. Waist-to-hip ratio (WHR): A defining morphological feature of health and female attractiveness. J Pers Soc Psychol 1993;65(2):293-307.
4. Szalay FS, Costello RK. Evolution of permanent estrus displays in hominids. J Hum Evol 1991;20:439-64.
5. Low B, Alexander RM, Noonan KM. Human hips, breasts, and buttocks: Is fat deceptive? Ethol Sociobiol 1987;8:249-57.
6. Moller AP, Pomiankowski A. Fluctuating asymmetry and sexual selection. Genetica 1993;89:267-79.
7. Thornhill R, Gangaestad SW. Human facial beauty: Averageness, symmetry, and parasite resistance. Human Nature 1993;4(3):237-69.
8. Bergfeld W. The evaluation and management of acne: Economic considerations. J Am Acad Dermatol 1995;5:S52-6.
9. Toyoda M, Morohashi M. Pathogenesis of acne. Med Electron Microsc 2001;34(1):29-40.
10. Leyden JJ. The evolving role of Propionibacterium acnes in acne. Semin Cutan Med Surg 2001;20:139-43.
11. Thiboutot D. Hormones and acne: Pathophysiology, clinical evaluation, and therapies. Semin Cutan Med Surg 2001;20:144-53.
12. Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol 1995;5:515-25.
13. Leyden JJ. Therapy for acne vulgaris. N Engl J Med 1997;336:1156-62.
14. Thiboutot DM. An overview of acne and its treatment. Cutis 1996;57:8-12.
15. Webster GF. Inflammation in acne vulgaris. J Am Acad Dermatol 1995;33(2 Pt 1):247-53.
16. Koreck A, Pivarcsi A, Dobozy A, Kemeny L. The role of innate immunity in the pathogenesis of acne. Dermatology 2003;206(2):96-105.
17. Jappe U. Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy. Acta Derm Venereol 2003;83:241-8.
18. Gollnick H. Current concepts of the pathogenesis of acne. Drugs 2003;63(15):1579-96.
19. Lee DJ, Van Dyke GS, Kim J. Update on pathogenesis and treatment of acne. Curr Opin Pediatr 2003;15:405-10.
20. Stewart ME, Downing DT, Cook JS, Hansen JR, Strauss JS. Sebaceous gland activity and serum dehydroepiandroste-one sulfate levels in boys and girls. Arch Dermatol 1992;128:1345-8.
21. Knaggs HE, Holland DB, Morris C, Wood EJ, Cunliffe WJ. Quantification of cellular proliferation in acne using the monoclonal antibody Di-67. J Soc Invest Dermatol 1994;102:89-92.
22. Cunliffe W, Forster R. Androgen control of the pilosebaceous duct? Br J Dermatol 1987;116:449.
23. Lookingbill D, Abrams B, Ellis C, et al. Inocoterone and acne. Arch Dermatol 1992;128:1197-200.
24. Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol 1986;14(2 Pt 1):221-5.
25. Guy R, Green MR, Kealey T. Modeling acne in vitro. J Invest Dermatol 1996;106:176-82.
26. Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003;63(15):1579-96.
27. Thiboutot D, Harris G, Iles V, Cimis G, Gilliland K, Hagari S. Activity of the type 1 5a-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J Invest Dermatol 1995;105:209-14.
28. Lucky AW, Biro FM, Simbartl LA, Morrison JA, Sorg NW. Predictors of severity of acne vulgaris in young adolescent girls: Results of a five-year longitudinal study. J Pediatr 1997;130:30-9.
29. White GM. Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris. J Am Acad Dermatol 1998;39(2 Pt 3):S34-37.
30. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton B, Brand-Miller J. Acne vulgaris: A disease of western civilization. Arch Dermatol 2002;138:1584-90.
31. Freyre E, Rebaza R, Sami D, Lozada C. The prevalence of facial acne in Peruvian adolescents and its relation to their ethnicity. J Adolesc Health 1998;22:480-4.
32. Wilkins JWJ, Voorhees JJ. Prevalence of nodulocystic acne in white and Negro males. Arch Dermatol 1970;102:631-4.
33. Hamilton J, Terada H, Mestler G. Greater tendency to acne in white American than in Japanese populations. J Clin Endocrinol Metab 1964;24:267-72.
34. Walton S, Wyatt E, Cunliffe WJ. Genetic control of sebum excretion and acne: A twin study. Br J Dermatol 1988;118:393-6.
35. Goulden V, McGeown CH, Cunliffe WJ. The familial risk of adult acne: A comparison between first-degree relatives of affected and unaffected individuals. Br J Dermatol 1999;141:297-300.
36. Bataille V, Snieder H, MacGregor AJ, Sasieni P, Spector TD. The influence of genetics and environmental factors in the pathogenesis of acne: A twin study of acne in women. J Invest Dermatol 2002;119(6):1317-22.
37. Dreno B, Poli F. Epidemiology of acne. Dermatology 2003;206(1):7-10.
38. Kellett S, Gilbert P. Acne: A biopsychosocial and evolutionary perspective with a focus on shame. Brit J Health Psychol 2001;6:1-24.
39. Jowett S, Ryan T. Skin disease and handicap: An analysis of the impact of skin conditions. Soc Sci Med 1985;20(4):425-9.
40. Wagner KD, Wagner Jr RF. Impact of acne on human sexuality. Med Aspects of Human Sexuality 1985;19(6):252-5.
41. Wallon E, Newton JN, Klassen A, Stewart-Brown SL, Ryan TJ, Finlay AY. The quality of life in acne: A comparison with general medical conditions using generic questionnaires. Br J Dermatol 1999;140(4):672-6.
42. Jowett S, Ryan T. Skin disease and handicap: An analysis of the impact of skin conditions. Soc Sci Med 1985;20(4):425-9.
43. Ponce de Leon MS, Zollikofer CP. Neanderthal cranial ontogeny and its implications for late hominid diversity. Nature 2001;412(6846):534-8.
44. Fuster JM. Frontal lobe and cognitive development. Neurocytol 2002;31(3-5):373-85.
45. Kaplan HS, Lancaster JB, Hill KR, Hurtado AM. A theory of human life history evolution: Diet, intelligence, and longevity. Evol Anthropol 2000;9:156-83.
46. Kaplan HS. Evolution and our reproductive physiology. Science 2001;293:809-10.
47. Cox G. De Virginibus Puerisque: The function of the human foreskin considered from an evolutionary perspective. Med Hypotheses 1995;45:617-21.
48. Blount JD, Metcalfe NB, Birkhead TR, Surai PF. Carotenoid modulation of immune function and sexual attractiveness in zebra finches. Science 2003;300:125-7.
49. Fink B, Grammer K, Thornhill RJ. Human (Homo sapiens) facial attractiveness in relation to skin texture and color. J Comp Psychol 2001;115(1):92-9.
50. Chen W, Zouboulis CC, Fritsch M, et al. Heterogeneity and quantitative differences of type 1 5α-reductase expression in cultured skin epithelial cells. Dermatology 1998;196(1): 51-2.
51. Akamatsu H, Zouboulis CC, Orfanos CE. Control of human sebocyte proliferation in vitro by testosterone and 5-alpha-dihydrotestoterone is dependent on the localization of the sebaceous glands. J Invest Dermatol 1992;99(4):509-11.
52. Pierard GE. Follicule to follicule heterogeneity of sebum excretion. Dermatologica 1986;173:61-5.
53. Rosenfield RL, Deplewski D. Role of androgens in the developmental biology of the pilosebaceous unit. Am J Med 1995;98(suppl 1A):80S-8S.
54. Monk B, Cunliffe WJ, Layton AM, Rhodes DJ. Acne induced by inhaled corticosteroids. Clin Exp Dermatol 1993;18:148-50.
55. American Medical Association Council on Drugs. Oral contraceptives: Current status of therapy. J Am Med Assoc December 28 1970;214(13):2316-21.
56. Evans NA. Gym and tonic: A profile of 100 male steroid users. Br J Sports Med 1997;31(1):54-8.
57. Alesci S, Bornstein SR. Neuroimmunoregulation of androgens in the adrenal gland and the skin. Horm Res 2000;54(5-6):281-6.
58. Frisch R. Weight at menarche: Similarity for well-nourished and undernourished girls at differing ages, and evidence for historical constancy. Pediatrics 1972;50:445-50.
59. Ader R, Felton DL, Cohen N, editors. Psychoneuroimmunology. 3rd ed. New York: Academic Press; 1991.