Cytogenetic study of metronidazole and three metronidazole analogues in cultured human lymphocytes with and without metabolic activation

Toxicology in Vitro

Volumn 18, Issue 3, 2004, Pages 319-324

  Gómez Arroyo, Sandra ^a   Melchor Castro, Sara ^a   Villalobos Pietrini, Rafael ^a   Camargo, Estela Meléndez ^b   Salgado Zamora, Héctor ^b   Campos Aldrete, Ma Elena ^b  

^a Lab de Citogenetica Ambiental   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Analysis of variance; ANOVA; BrdU; Bromodeoxyuridine; Cell proliferation kinetics; CPK; Metronidazole; Nitroimidazole derivatives; Replication index and mitotic index; SCE; Sister chromatid exchange; Sister chromatid exchange test;

Indexed keywords

1 (4 FLUOROPHENACYL) 2 METHYL 4 NITROIMIDAZOLE; 1 (4 METHOXYPHENACYL) 2 METHYL 4 NITROIMIDAZOLE; 1 (4 METHYLPHENACYL) 2 METHYL 4 NITROIMIDAZOLE; ANTIINFECTIVE AGENT; METRONIDAZOLE; NITROIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL KINETICS; CELL PROLIFERATION; CHROMATID EXCHANGE; CONTROLLED STUDY; CYTOGENETICS; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENTAMOEBA HISTOLYTICA; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; METABOLIC ACTIVATION; MITOSIS INDEX; NONHUMAN; STATISTICAL SIGNIFICANCE;

ANTI-INFECTIVE AGENTS; BIOTRANSFORMATION; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYTOGENETIC ANALYSIS; HUMANS; LYMPHOCYTES; METRONIDAZOLE; MITOTIC INDEX; SISTER CHROMATID EXCHANGE;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; PROTOZOA;

EID: 1642303816     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2003.09.006     Document Type: Article

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