The role of iodine in antisepsis and wound management: A reappraisal

Acta Chirurgica Belgica

Volumn 103, Issue 3, 2003, Pages 241-247

  Selvaggi, G ^a   Monstrey, S ^a   Van Landuyt, K ^a   Hamdi, M ^a   Blondeel, Ph ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Antisepsis; Iodine; Povidone iodine; Wound healing

Indexed keywords

ACETIC ACID DERIVATIVE; ALCOHOL; AMMONIUM DERIVATIVE; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CADEXOMER IODINE; CHLORHEXIDINE; CHLORINE DERIVATIVE; HEXAMIDINE; HEXETIDINE; IODINE; IODOPHOR; POTASSIUM IODATE; POVIDONE IODINE; SODIUM IODIDE;

ALLERGY; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ANTISEPSIS; CONTACT DERMATITIS; CONVULSION; DRUG ACTIVITY; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; HUMAN; IODINE DEFICIENCY; KIDNEY FAILURE; LONG TERM CARE; METABOLIC ACIDOSIS; NEUROTOXICITY; NEWBORN DISEASE; NONHUMAN; PERITONITIS; REVIEW; SIDE EFFECT; THYROID DISEASE; WOUND CARE; WOUND HEALING; WOUND INFECTION;

EID: 1642295132     PISSN: 00015458     EISSN: 25770160     Source Type: Journal    
DOI: 10.1080/00015458.2003.11679417     Document Type: Review

References (57)

1. FLEISCHER W., REIMER K. Povidone-Iodine in Antisepsis-State of the Art. Dermatology, 1997, 195 (suppl 2) : 3-9.
2. GERSHENFELD L. Povidone-iodine as a topical antiseptic. Am J Surg, 1957, 94 : 938-939.
3. DAVAINE M. D. Recherches sur le traitment des maladies charbonneuses chez l'homme. Bull Acad Natl Med Paris, 1880, 9 : 757.
4. GULLIVER G. Wound Care. Arguments over iodine. Nursing Time, 1999, 95 (27) : 68-70.
5. SCHELANSKI H. A., SHELANSKI M. V. PVP-iodine : History, toxicity and therapeutic uses. J Int Coll Surg, 1956, 25 : 727-737.
6. LAWRENCE J. C. The use of iodine as an antiseptic agent. J Wound Care, 1998, 7 (8) : 421-5.
7. th edn). Martindale eds. London : The Pharmaceutical Press, 1989.
8. th ed. Lea & Febiger, Philadelphia, Pa., 1991 : 152-166.
9. HIGGINS D. G. Povidone iodine : the tamed iodine. Chemist and Druggist, 1975, August 30, 274-275.
10. LACEY R. W., CATTO A. Action of povidone-iodine against methicillin sensitive and -resistant cultures of Staphylococcus aureus. Postgrad Med J, 1993, 69 : (suppl 3), S78-S83.
11. BERKELMAN R. L., HOLLAND B. W., HANDERSON R. L. Increased bactericidal activity of dilute preparations of povidone-iodine solutions. J Clin Microbiol, 1982, 15 : 635-639.
12. RACKUR H. New aspects of mechanism of action of povidone-iodine. J Hosp Infect, 1985, 6 (suppl A) : 13-23.
13. MAYER D. A. Povidone-Iodine and Wound Healing : A Critical Review. Wounds, 1993, 5 (1) : 14-23.
14. JENG D. K., SEVERIN J. E. Povidone iodine gel alcohol : a 30-second onetime application preoperative skin preparation. Am J Infect Control, 1998 Oct, 26 (5) : 488-94.
15. CAHUZAC J. P., LARENG B., PRERE M. F., DENIS P., GREIG G. Evaluation de l'activité bactericide de la PVP-I at de la chlorhexidine. Therapeutique, Abstract Hospital N 11, Oct, 1991 : 27-30.
16. REVERDY M. E., MARTRA A., ALLAERT F. A., NONY P., FRENEY J. Cinetique de bactericide de la PVP-I, solution dermique, sur la flore residente du pli du coude, après application de 15 ou 30 secondes. Med Mal Infect, 1997, 27 : 711-4.
17. CALFEE D. P., FARR B. M. Comparison of four antiseptic preparations for skin in the prevention of contamination of percutaneously drawn blood cultures : a randomized trial. J Clin Microbiol, 2002 May, 40 (5) : 1660-5.
18. ARATA T., MURAKAMI T., HIRAI Y. Evaluation of povidone-iodine alcoholic solution for operative site disinfection. Postgrad Med J, 1993, 69 Suppl 3 : S93-6.
19. KUTARSKI P. W., GRUNDY H. C. To dry or not to dry? An assessment of the possible degradation in efficiency of preoperative skin preparation caused by wiping skin dry. Annals of Royal College of Surgeons of England (1993) vol. 75, 181-185.
20. SUNDBERG J. A retrospective review of cadexomer iodine in the treatment of chronic wounds. Wounds, 1997, 9 : 68-86.
21. GORDON J. Clinical significance of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in UK hospitals and the relevance of povidone-iodine in their control. Postgrad Med J, 1993, 69 (suppl 3) : 106-115.
22. th ed. Lea & Febiger, Philadelphia, Pa, 1991 : 441-444.
23. SPRINGTHORPE V. S., SATTER S. A. Chemical disinfection of virus-contaminated surfaces. Crit Rev Environ Control, 1990, 20 : 169-229.
24. RUTALA W. A. APIC guidelines for selection and use of disinfectants. Am J Infect Control, 1995, 23 : 313-342.
25. LARSON E. L. Antiseptics. In : OLMSTAD R. N. (ed.). APIC infection control & applied epidemiology : principles & practices. Mosby-Year Book, Inc., St. Louis, Mo., 1996 : 19-1, 19-7, G1-G17.
26. MUNSON. Principles of Pharmacology, Chapman & Hall, 1995.
27. PIERARD G. E., PIERARD-FRANCHIMONT C., ARRESE J. E. Povidone-iodine wash solution in the prevention of superficial fungal infections, predictive evaluation using the corneofungimetry bioassay. Eur J Clin Pharmacol, 1997, 53 (2) : 101-104.
28. GOLDENHEIM D. In vitro efficacy of povidone-iodine solution and cream against methicillin-resistant Staphylococcus aureus. Postgrad Med J, 1993, 69 (suppl.3) : S62-S65.
29. MCLURE A. R. In-vitro evaluation of povidone-iodine and chlorexidine against methicilin-resistant Staphylococcus aureus. J of Hospital Infection, 1992, 21 : 291-299.
30. BLOCK C., ROBENSHTOK E., SIMHON A., SHAPIRO M. Evaluation of chlorexidine and povidone iodine activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis using a surface test. J Hosp Infect, 2000 Oct, 46 (2): 147-152.
31. MCDONNEL G., RUSSEL D. Antiseptics and Disinfectants : activity, action and resistance. Clinical Microbiology Reviews, 1999 Jan : 147-179.
32. KUNISADA T., YAMADA K., ODA S., HARA O. Investigation on the efficacy of povidone-iodine against antiseptic-resistant species. Dermatology, 1997, 195 (suppl 2) : 14-8.
33. KRAMER S. A. Effect of povidone-iodine on wound healing : a review. J Vasc Nurs, 1999 Mar, 17 (1) : 17-23.
34. LINEAWEAVER W., HOWARD R., SOUCY D., MCMORRIS S., FREEMAN J., CRAIN C., ROBERTSON J., RUMLEY T. Topical Antimicrobial Toxicity. Arch Surg, 1985, 120 (3) : 267-270.
35. GILCHRIST B. Should iodine be reconsidered in wound management? Journal of wound care, 1997, 6 (3) : 148-150.
36. MOORE K. Iodine Realeased from the Wound Dressing Iodosorb Modulates the Secretion of Cytokines by Human Macrophages responding to Bacterial Lipopolysaccharide. Int Biochem Cell Biol, 1997, 29(1): 163-171.
37. BENNET L. L., ROSENBLUM R. S., PERLOV C., DAVIDSON J. M., BARTON R. M., NANNEY L. B. An in vivo comparison of topical agents on wound repair. Plastic and Reconstructive Surgery, 2001 Sep, 108 (3) : 675-685.
38. FUMAL I., BRAHAM C., PAQUET P., PIERARD-FREANCHIMONT C., PIERARD G. E. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora : a proof-of-concept study. Dermatology, 2002, 204 Suppl 1 : 70-4.
39. SCHMIDT R., KIRBY A., CHUNG L. Cadexomer iodine formulations may modulate the redox environment of wounds. In : Iodine and Wound Physiology. Cambridge : Information Transfer Ltd, 1995.
40. RUSSEL A. D., DAY M. J. Antibiotic and biocide resistance in bacteria. Microbios, 1996, 85 (342) : 45-65.
41. HEIR E., LANGSRUD S., SIDHU M. S., STEINBAKK M. Can disinfectants contribute to antibiotic resistance? Tidsskr Nor Laegeforen, 2001, 121 (27): 3201-6.
42. JONES R. D. Bacterial resistance and topical antimicrobial wash products. Am J Infect Control, 1999, 27 (4) : 351-363.
43. LANKER KLOSSNER B., WIDMER H. R., FREY F. Nondevelopment of Resistance by Bacteria during Hospital Use of Povidone-Iodine. Dermatology, 1997, 195 (suppl 2) : 10-13.
44. MICOCK G. Methicillin / antiseptic-resistant Staphylococcus aureus. Lancet, 1985 Oct 26, 2 (8461) : 949-50.
45. SHIRASHI T., OKA R., NAKAGAWA Y. Pharmaceutical and bacteriological study on povidone-iodine sugar ointment. Dermatology, 1997, 195 (Suppl 2) : 100-3.
46. PAYNE D. N., GIBSON S. A. W., LEWIS R. Antiseptics : a forgotten weapon in the control of antibiotic resistant bacteria in hospital and community settings? J Roy Soc Health, 1998, 118 (1) : 18-22.
47. CAMPISTOL J. M., ABAD C., NOGUE S., BERTRAN A. Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation. J cardiovasc Surg Torino, 1988, 28 : 410-412.
48. ZEC N., DONOVAN J. W., AUFIERO T. X., KINCAID R. L., DEMERS L. M. Seizures in a patient treated with continuous povidone-iodine mediastinal irrigation (letter). N Engl J Med, 1992, 326 : 1784).
49. KEATING J. P., NEILL M., HILL G. L. Sclerosing encapsulationg peritonitis after intraperitoneal use of povidone iodine. Aust NZ J Surg, 1997, 67 : 742-744.
50. LINDER N., DAVIDOVITCH N., REICHMAN B., KUINT J., HEGESH J., LUBIN D., SACK J. Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. J Pediatr, 1997, 131 : 434-439.
51. BROWN R. S., BLOOMFIELD S., BEDNAREK F. J., MITCHELL M. L., BRAVERMAN L. E. Routine skin cleansing with povidone-iodine is not a common cause of transient neonatal hypothyroidism in North America : A retrospective controlled study. Thyroid, 1997, 7 : 395-400.
52. STEEN M. Review of the use of povidone-iodine (PVP-I) in the treatment of burns. Postgrad Med J, 1993, 69 (suppl) 3 : S84-92.
53. OKANO M. Irritant contact dermatitis caused by povidone-iodine (letter). J Am Acad Dermatol, 1989, 20 : 860.
54. TOSTI A., VINCENZI C., BARDAZZI F., MARIANI R. Allergic contact dermatitis due to povidone-iodine. Contact Dermatitis, 1990, 23 : 197-198.
55. POHL-MARKL H., NEUMANN R. Polyvinylpyrrolidon-Jod (PVP-Jod) -Seine Bedeutung fur die Dermatologie. Z Hautkr, 1988, 63: 1009-1015.
56. JUHASZ I. Experiences with the use of povidone-iodine-containing local therapeutics in dermatological surgery and in the treatment of burns : testing for allergic sensitization in postsurgery patients. Dermatology, 2002, 204 Suppl. 1 : 52-8.
57. SHETTY K. R., DUTHIE E. H. Jr. Thyrotoxicosos induced by topical iodine application. Arch Intern Med, 1990, 150 : 2400-2401.