pH-Dependent Chemoselective Synthesis of α-Amino Acids. Reductive Amination of α-Keto Acids with Ammonia Catalyzed by Acid-Stable Iridium Hydride Complexes in Water

Journal of the American Chemical Society

Volumn 126, Issue 10, 2004, Pages 3020-3021

  Ogo, Seiji ^a   Uehara, Keiji ^a   Abura, Tsutomu ^a   Fukuzumi, Shunichi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID; ALPHA AMINO ACID; AMMONIA; CARBONYL DERIVATIVE; IRIDIUM;

AMINATION; ARTICLE; CATALYSIS; CHEMOSENSITIVITY; MOLECULAR STABILITY; PH MEASUREMENT; PROTON TRANSPORT; SYNTHESIS;

AMINATION; AMINO ACIDS; AMMONIA; CATALYSIS; HYDROGEN-ION CONCENTRATION; IRIDIUM; KETO ACIDS; OXIDATION-REDUCTION; WATER;

EID: 1642294099     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja031633r     Document Type: Article

References (19)

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14. 4 acts as an amine source as well as a hydride ion source.
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16. 2 was confirmed by GC analysis.
17. a value of HCOOH is 3.6 at 25 °C.
18. 1H NMR.
19. 4 = 1(277.5 μmol)/200 (55.5 mmol)/4000 (1.11 mol), 80 °C, 24 h.