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1642394554
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note
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Diaminophosphine oxide 4 is an air- and moisture-stable solid. See the Supporting Information for details of the conversion of 3 to 4.
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25
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1642412279
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note
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Reaction using simple allyl acetate gave less satisfactory results [cat. 5 mol %, keto ester 6g, 48 h, 24%, 63% ee, absolute configuration S].
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1642363712
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See the Supporting Information for details.
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27
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1642405800
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note
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31P NMR measurement of the reaction mixture, which might indicate that several complexes exist in a fast equilibrium.
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1642384915
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note
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At the present stage, we speculate that the nitrogen atoms might fix the nucleophiles in the appropriate position through secondary ligand substrate interaction mediated by Zn metal. For the secondary ligand substrate interaction, see ref 10a-c.
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