Cytoplasmic expression of nm23 predicts the potential for cerebral metastasis in patients with primary cutaneous melanoma

Melanoma Research

Volumn 14, Issue 1, 2004, Pages 23-27

  Sarris, Maria ^a,b,e   Scolyer, Richard A ^c   Konopka, Michael ^d   Thompson, John F ^b,c   Harper, Clive G ^b,c   Lee, Soon C ^b,c  

^a Neurosci Inst Schizophrenia A   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d SKIN AND CANCER FOUNDATION AUSTRALIA   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Brain metastases; Melanoma; nm23

Indexed keywords

ADULT; ARTICLE; BRAIN CANCER; BRAIN METASTASIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; METASTASIS; MULTIGENE FAMILY; NM23 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CANCER;

EID: 1642276564     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200402000-00004     Document Type: Article

References (34)

1. Akslen LA, Hove LM, Hartveit F. Metastatic distribution in malignant melanoma. A 30-year autopsy study. Invasion Metastasis 1987; 7 (5):253-263.
2. Fidler IJ. Critical determinants of cancer metastasis: rationale for therapy. Cancer Chemother Pharmacol 1999; 43 (suppl):S3-10.
3. Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339 (6219):58-61.
4. Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80 (3):200-204.
5. Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS. Identification of a second human nm23 gene, nm23-H2. Cancer Res 1991; 51 (1):445-449.
6. Freije JM, MacDonald NJ, Steeg PS. Differential gene expression in tumor metastasis: nm23. Curr Top Microbiol Immunol 1996; 213 (pt 2):215-232.
7. Liotta LA, Steeg PS. Clues to the function of Nm23 and Awd proteins in development, signal transduction, and tumor metastasis provided by studies of Dictyostelium discoideum. J Natl Cancer Inst 1990; 82 (14):1170-1172.
8. Nickerson JA, Wells WW. The microtubule-associated nucleoside diphosphate kinase. J Biol Chem 1984; 259 (18):11297-11304.
9. Steeg PS, de la Rosa A, Flatow U, MacDonald NJ, Benedict M, Leone A. Nm23 and breast cancer metastasis. Breast Cancer Res Treat 1993; 25 (2):175-187.
10. MacDonald NJ, De la Rosa A, Benedict MA, Freije JM, Krutsch H, Steeg PS. A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. J Biol Chem 1993; 268 (34):25780-25789.
11. Leone A, Flatow U, King CR, Sandeen MA, Margulies IM, Liotta LA, Steeg PS. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 1991; 65 (1):25-35.
12. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 1989; 49 (18):5185-5190.
13. Hennessy C, Henry JA, May FE, Westley BR, Angus B, Lennard TW. Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis. J Natl Cancer Inst 1991; 83 (4):281-285.
14. Lee CS, Pirdas-Zivcic A. nm23-H1 protein immunoreactivity in cancers of the gallbladder, extrahepatic bile ducts and ampulla of Vater. Pathology 1994; 26 (4):448-452.
15. Cohn KH, Wang FS, Desoto-LaPaix F, Solomon WB, Patterson LG, Arnold MR, et al. Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma. Lancet 1991; 338 (8769):722-724.
16. Barnes R, Masood S, Barker E, Rosengard AM, Coggin DL, Crowell T, et al. Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am J Pathol 1991; 139 (2):245-250.
17. Florenes VA, Aamdal S, Myklebost O, Maelandsmo GM, Bruland OS, Fodstad O. Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res 1992; 52 (21):6088-6091.
18. Francis B, Overmeyer J, John W, Marshall E, Haley B. Prevalence of nucleoside diphosphate kinase autophosphorylation in human colon carcinoma versus normal colon homogenates. Mol Carcinog 1989; 2 (3):168-178.
19. Lacombe ML, Sastre-Garau X, Lascu I, Vonica A, Wallet V, Thiery JP, Veron M. Overexpression of nucleoside diphosphate kinase (Nm23) in solid tumours. Eur J Cancer 1991; 27 (10):1302-1307.
20. Sarris M, Lee CS. Increased expression of nm23 protein in colorectal adenocarcinoma. J Histotechnol 2000; 23 (2):133-137.
21. McDermott NC, Milburn C, Curran B, Kay EW, Barry Walsh C, Leader MB. Immunohistochemical expression of nm23 in primary invasive malignant melanoma is predictive of survival outcome. J Pathol 2000; 190 (2):157-162.
22. van den Oord JJ, Maes A, Stas M, Nuyts J, De Wever I, De Wolf-Peeters C. Prognostic significance of nm23 protein expression in malignant melanoma. An immunohistochemical study. Melanoma Res 1997; 7 (2):121-128.
23. Easty DJ, Maung K, Lascu I, Veron M, Fallowfield ME, Hart IR, et al. Expression of NM23 in human melanoma progression and metastasis. Br J Cancer 1996; 74 (1):109-114.
24. Holmes SC, MacKie RM. The value of Nm23 expression as an independent prognostic indicator in primary thick melanoma J Cutan Pathol 1996; 23 (4):344-349.
25. Saitoh K, Takahashi H, Yamamoto M, Kishi H, Parsons PG. Expression of metastasis suppressor gene product, nm23 protein, is not inversely correlated with the tumour progression in human malignant melanomas. Histopathology 1996; 29 (6):497-505.
26. Royds JA, Cross SS, Silcocks PB, Scholefield JH, Rees RC, Stephenson TJ. Nm23 'anti-metastatic' gene product expression in colorectal carcinoma. J Pathol 1994; 172 (3):261-266.
27. Hirayama R, Sawai S, Takagi Y, Mishima Y, Kimura N, Shimada N, et al. Positive relationship between expression of anti-metastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst 1991; 83 (17):1249-1250.
28. Radinsky R, Weisberg HZ, Staroselsky AN, Fidler IJ. Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms. Cancer Res 1992; 52 (20):5808-5814.
29. Sawan A, Lascu I, Veron M, Anderson JJ, Wright C, Horne CH, Angus B. NDP-K/nm23 expression in human breast cancer in relation to relapse, survival, and other prognostic factors: an immunohistochemical study. J Pathol 1994; 172 (1):27-34.
30. Xerri L, Grob JJ, Battyani Z, Gouvernet J, Hassoun J, Bonerandi JJ. NM23 expression in metastasis of malignant melanoma is a predictive prognostic parameter correlated with survival. Br J Cancer 1994; 70 (6):1224-1228.
31. Reichrath J, Seyfried P, Braun R, Muller SM, Baum HP, Bahmer FA. Expression of NM23 protein in acquired melanocytic nevi, malignant melanoma and metastases of malignant melanoma: an immunohistological assessment in human skin. Dermatology 1997; 194 (2):136-139.
32. Rusciano D. Differentiation and metastasis in melanoma. Crit Rev Oncog 2000; 11 (2):147-163.
33. Seregard S, Oskarsson M, Spangberg B. Differential expression of nm23 H-1 protein in conjunctival melanoma and potential precursor lesions. Exp Eye Res 1999; 69 (6):671-676.
34. Bodey B, Bodey B Jr, Groger AM, Siegel SE, Kaiser HE. Nm23/nucleoside diphosphate (NDP) kinase expression in human malignant melanomas: significance and implications in tumor biology. Anticancer Res 1997; 17 (1A):505-511.