Targeting protein homodimerization: A novel drug discovery system

FEBS Letters

Volumn 579, Issue 10, 2005, Pages 2065-2070

  Furuta, Eiji ^a   Yamamoto, Kaneyoshi ^a   Tatebe, Daisuke ^a   Watabe, Kounosuke ^b   Kitayama, Takashi ^a   Utsumi, Ryutaro ^a  

^a KINKI UNIVERSITY   (Japan)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotics; Histidine kinase inhibitor; Homodimerization; Two component system; YycG

Indexed keywords

1 DODECYL 2 ISOPROPYLIMIDAZOLE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; IMIDAZOLE DERIVATIVE; PROTEIN HISTIDINE KINASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL GENE; BACTERICIDAL ACTIVITY; DIMERIZATION; DRUG IDENTIFICATION; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; GENETIC CODE; HIGH THROUGHPUT SCREENING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; STAPHYLOCOCCUS AUREUS;

EID: 16344375867     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.02.056     Document Type: Article

References (27)

1. C. Walsh Antibiotics: actions, origins, resistance 2003 American Society for Microbiology Publishing Washington, DC
2. M. Matsushita, and D.K. Janda Histidine kinase as targets for new antimicrobial agents Bioorg. Med. Chem. 10 2002 855 867
3. J.F. Barrett, and J.A. Hoch Two-component signal transduction as a target for microbial anti-infective therapy Antimicrob. Agents Chemother. 42 1998 1529 1536
4. M.J. Macielag, and R. Goldschmidt Inhibitors of bacterial two-component signaling systems Exp. Opin. Invest. Drugs 9 2000 2351 2369
5. A. Howell, S. Dubrac, K.K. Andersen, D. Noone, J. Fert, T. Msadek, and K. Devine Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach Mol. Microbiol. 49 2003 1639 1655
6. S. Dubrac, and T. Msadek Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus J. Bacteriol. 186 2004 1175 1181
7. P.K. Martin, T. Li, D. Sun, D.P. Biek, and M.B. Schmid Role in cell permeability of an essential two-component system in Staphylococcus aureus J. Bacteriol. 181 1999 3666 3673
8. T. Watanabe, Y. Hashimoto, K. Yamamoto, K. Hirao, A. Ishihama, M. Hino, and R. Utsumi Isolation and characterization of inhibitors of the essential histidine kinase, YycG in Bacillus subtilis and Staphylococcus aureus J. Antibiot. 56 2003 1045 1052
9. C. Fabret, and J.A. Hoch A two-component signal transduction system essential for growth of Bacillus subtilis: Implications for anti-infective therapy J. Bacteriol. 180 1998 6375 6383
10. L. Hancock, and M. Perego Two-component signal transduction in Enterococcus faecalis J. Bacteriol. 184 2002 5819 5825
11. M.G. Surette, M. Levit, Y. Liu, G. Lukat, E.G. Ninfa, A. Ninfa, and J.B. Stock Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis J. Biol. Chem. 271 1996 939 945
12. T. Tanaka, S.K. Saha, C. Tomomori, R. Ishima, D. Liu, K.I. Tong, H. Park, R. Dutta, L. Qin, M.B. Swindells, T. Yamazaki, A.M. Ono, M. Kainosho, M. Inouye, and M. Ikura NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ Nature 396 1998 88 92
13. Y. Hidaka, H. Park, and M. Inouye Demonstration of dimer formation of the cytoplasmic domain of a transmembrane osmosensor protein, EnvZ, of Escherichia coli using Ni-histidine tag affinity chromatography FEBS Lett. 400 1997 238 242
14. C. Tomomori, T. Tanaka, R. Dutta, H. Park, S.K. Saha, Y. Zhu, R. Ishima, D. Liu, K.I. Tong, H. Kurokawa, H. Qian, M. Inouye, and M. Ikura Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ Nat. Struct. Biol. 6 1999 729 734
15. J.P. Throup, K.K. Koretke, A.P. Bryant, K.A. Ingraham, A.F. Chalker, Y. Ge, A. Marra, N.G. Wallis, J.R. Brown, D.J. Holmes, M. Rosenberg, and M.K Burnham A genomic analysis of two-component signal transduction in Streptococcus pneumoniae Mol. Microbiol. 35 2000 566 576
16. S.H. Park, and R.T. Raines Genetic selection for dissociative inhibitors of designated protein-protein interactions Nat. Biotechnol. 18 2000 847 851
17. H. Makinoshima, A. Nishimura, and A. Ishihama Fractionation of Escherichia coli cell populations at different stages during growth transition to stationary phase Mol. Microbiol. 43 2002 269 279
18. G. Karimova, J. Pidoux, A. Ullmann, and D. Ladant A bacterial two-hybrid system based on a reconstituted signal transduction pathway Proc. Natl. Acad. Sci. USA 95 1998 5752 5756
19. A. Blondel, and H. Bedouelle Engineering the quaternary structure of an exported protein with a leucine zipper Protein Eng. 4 1991 457 461
20. N. Raman, P.N. Black, and C.C. DiRusso Characterization of the fatty acid-responsive transcription factor FadR. Biochemical and genetic analyses of the native conformation and functional domains J. Biol. Chem. 272 1997 30645 30650
21. I. Martinez-Argudo, J. Martin-Nieto, P. Salinas, R. Maldonado, M. Drummond, and A. Contreras Two-hybrid analysis of domain interactions involving NtrB and NtrC two-component regulators Mol. Microbiol. 40 2001 169 178
22. R.G. Zhang, Y. Kim, T. Skarina, S. Beasley, R. Laskowski, C. Arrowsmith, A. Edwards, A. Joachimiak, and A. Savchenko Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family J. Biol. Chem. 277 2002 19183 19190
23. L.J. Donald, D.J. Hosfield, S.L. Curvelier, W. Ens, K.G. Standing, and H.W. Duckworth Mass spectrometric study of the Escherichia coli repressor proteins, IclR and GclR, and their complexes with DNA Protein Sci. 10 2001 1370 1380
24. K. Yamamoto, and A. Ishihama Two different modes of transcription repression of the Escherichia coli acetate operon by IclR Mol. Microbiol. 47 2003 183 194
25. L. Gui, A. Sunnarborg, B. Pan, and D.C. LaPorte Autoregulation of iclR, the gene encoding the repressor of the glyoxylate bypass operon J. Bacteriol. 178 1996 321 324
26. K. Yamamoto, T. Kitayama, S. Minagawa, T. Watanabe, S. Sawada, T. Okamoto, and R. Utsumi Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis Biosci. Biotechnol. Biochem. 65 2001 2306 2310
27. W.C. Noble, Z. Virani, and R.G. Cree Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus FEMS Microbiol. Lett. 72 1992 195 198