Controlling the gap: Myocytes, matrix, and mechanics

Circulation Research

Volumn 96, Issue 5, 2005, Pages 485-487

  Spragg, David D ^a   Kass, David A ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Beta integrins; Connexin43; Extracellular matrix; Mechanotransduction

Indexed keywords

CONNEXIN 43; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; VASCULOTROPIN;

CARDIOMYOPATHY; CELL NUCLEUS; CELL PH; DESMOSOME; DOWN REGULATION; EDITORIAL; EXTRACELLULAR MATRIX; GAP JUNCTION; HEART ARRHYTHMIA; HEART CONTRACTION; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART VENTRICLE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; CELL ADHESION; CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; EXTRACELLULAR MATRIX; GAP JUNCTIONS; HUMANS; MYOCYTES, CARDIAC; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 16244415842     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000160607.30286.54     Document Type: Editorial

References (24)

1. Teunissen BEJ, Bierhuizen MFA. Transcriptional control of myocardial connexins. Cardiovasc Res. 2004;62:246-255.
2. Saffitz JE, Laing JG, Yamada KA. Connexin expression and turnover: implications for cardiac excitability. Circ Res. 2000;86:723-728.
3. Herve JC, Duthe F, Dupont E, Plaisance I, Verrecchia F, Severs NJ, Sarrouilhe D. Dephosphorylating treatments depress gap junctional communication between rat cardiac cells without modifying the connexin43 phosphorylation degree. Journal of Physiology-London. 2000;527: 122P-123P.
4. Duffy HS, Ashton AW, Coombs W, Taffet SM, Delmar M, Spray DC. Regulation of connexin43 protein complexes by intracellular acidification. J Neurochem. 2004;90:29.
5. Dupont E, Matsushita T, Kaba RA, Vozzi C, Coppen SR, Khan N, Kaprielian R, Yacoub MH, Severs NJ. Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol. 2001;33:359-371.
6. Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Reduced content of connexin43 gap-junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation. 1993;88:864-875.
7. Akar FG, Spragg DD, Tunin RS, Kass DA, Tomaselli GF. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ Res. 2004;95:717-725.
8. Kaprielian RR, Gunning M, Dupont E, Sheppard MN, Rothery SM, Underwood R, Pennell DJ, Fox K, Pepper J, Poole-Wilson PA, Severs NJ. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation. 1998;97:651-660.
9. Lerner DL, Chapman Q, Green KG, Saffitz JE. Reversible down-regulation of connexin43 expression in acute cardiac allograft rejection. J Heart Lung Transplant. 2001;20:93-97.
10. Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, Kleber AG, Schuessler RB, Saffitz JE. Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res. 2000;87:656-662.
11. Ai X, Pogwizd SM. Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circ Res. 2005;96:54-63.
12. Petrich BG, Gong XH, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang YB. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res. 2002;91:640-647.
13. Chu GX, Carr AN, Young KB, Lester JW, Yatani A, Sanbe A, Colbert MC, Schwanz SM, Frank KF, Lampe PD, Robbins J, Molkentin JD, Kranias EG. Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. Cardiovasc Res. 2002;54: 105-116.
14. Darrow BJ, Fast VG, Kleber AG, Beyer EC, Saffitz JE. Functional and structural assessment of intercellular communication - Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996;79:174-183.
15. Saffitz JE, Kleber AG. Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart. Circ Res. 2004;94:585-591.
16. Zhuang J, Yamada KA, Saffitz JE, Kleber AG. Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circ Res. 2000;87: 316-322.
17. Pimentel RC, Yamada KA, Kleber AG, Saffitz JE. Autocrine regulation of myocyte Cx43 expression by VEGF. Circ Res. 2002;90:671-677.
18. Shanker AJ, Yamada K, Green KG, Yamada KA, Saffitz JE. Matrix protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load. Circ Res. 2005;96:560-568.
19. Yamamoto K, Dang QN, Maeda Y, Huang H, Kelly RA, Lee RT. Regulation of cardiomyocyte mechanotransduction by the cardiac cycle. Circulation. 2001;103:1459-1464.
20. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad and the ugly. Annu Rev Physiol. 2003;65:45-79.
21. Prestle J, Dieterich S, Preuss M, Bieligk U, Hasenfuss G. Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart. Cardiovasc Res. 1999;43:323-331.
22. Antzelevitch C. The role of electrical heterogeneity in arrhythmogenesis. Journal of Physiology-London. 2002;544:4S-5S.
23. Spragg DD, Akar FG, Tunin RS, Tomaselli GF, Kass DA. Left ventricular dyssynchrony induces gap junction remodeling and conduction defects in late-activated myocardium. Circulation. 2003;108:56.
24. Baldasseroni S, Opasich C, Gorini M, Lucci D, Marchionni N, Marini M, Campana C, Perini G, Deorsola A, Masotti G, Tavazzi L, Maggioni AP. Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: a report from the Italian network on congestive heart failure. Am Heart J. 2002;143:398-405.