Gemcitabine and cisplatin in advanced nasopharyngeal carcinoma: A pilot study

Cancer Investigation

Volumn 23, Issue 2, 2005, Pages 123-128

  Jiang, Yu ^a   Wei, Yu Quan ^a   Luo, Feng ^a   Zou, Li Qun ^a   Liu, Ji Yan ^a   Peng, Feng ^a   Huang, Mei Juan ^a   He, Qiu Ming ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Chemotherapy; Cisplatin; Gemcitabine; Nasopharyngeal carcinoma

Indexed keywords

CISPLATIN; FLUOROURACIL; GEMCITABINE;

ADULT; ALOPECIA; ANEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLEEDING; CANCER CHEMOTHERAPY; CANCER GRADING; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EDEMA; FATIGUE; FEBRILE NEUTROPENIA; FEMALE; HEARING LOSS; HUMAN; LUNG TOXICITY; MALE; MEDICAL ASSESSMENT; METASTASIS; MUCOSA INFLAMMATION; NASOPHARYNX CARCINOMA; NAUSEA; NEPHROTOXICITY; NEUROPATHY; NEUTROPENIA; PILOT STUDY; PRIORITY JOURNAL; RASH; RESPONSE TIME; THROMBOCYTOPENIA; TINNITUS; VOMITING;

EID: 16244386581     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1081/CNV-50438     Document Type: Article

References (30)

1. Gunven, P.; Klein, G.; Henle, G.; Henle, W.; Clifford, P. Epstein-Barr virus in Burkitt's lymphoma and nasopharyngeal carcinoma. Antibodies to EBV associated membrane and viral capsid antigens in Burkitt lymphoma patients. Nature 1970, 228 (276), 1053-1056.
2. Chien, Y.C.; Chen, J.Y.; Liu, M.Y.; Yang, H.I.; Hsu, M.M.; Chen, C.J.; Yang, C.S. Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. N. Engl. J. Med. 2001, 345 (26), 1877-1882.
3. Hoe, J.W. Computed tomography of nasopharyngeal carcinoma. A review of CT appearances in 56 patients. Eur. J. Radiol. 1989, 9 (2), 83-90.
4. King, A.D.; Ahuja, A.T.; Leung, S.F.; Lam, W.W.; Teo, P.; Chan, Y.L.; Metreweli, C. Neck node metastases from nasopharyngeal carcinoma: MR imaging of patterns of disease. Head Neck 2000, 22 (3), 275-281.
5. Tsao, S.Y.; Shiu, W.C. Radiotherapy and chemotherapy for nasopharyngeal carcinoma. Ear Nose Throat. J. 1990, 69 (4), 272-278.
6. Chan, A.T.; Teo, P.M.; Leung, T.W.; Johnson, P.J. The role of chemotherapy in the management of nasopharyngeal carcinoma. Cancer 1998, 82 (6), 1003-1012.
7. Merino, O.R.; Lindberg, R.D.; Fletcher, G.H. An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1977, 40 (1), 145-151.
8. Cheng, S.H.; Yen, K.L.; Jian, J.J.; Tsai, S.Y.; Chu, N.M.; Leu, S.Y.; Chan, K.Y.; Tan, T.D.; Cheng, J.C.; Hsieh, C.Y.; Huang, A.T. Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials. Int. J. Radiat. Oncol. Biol. Phys. 2001, 50 (3), 717-726.
9. Teo, P.; Shiu, W.; Leung, S.F.; Lee, W.Y. Prognostic factors in nasopharyngeal carcinoma investigated by computer tomography - an analysis of 659 patients. Radiother. Oncol. 1992, 23 (2), 79-93.
10. Lin, J.C.; Jan, J.S.; Hsu, C.Y. Outpatient weekly chemotherapy in patients with nasopharyngeal carcinoma and distant metastasis. Cancer 1998, 83 (4), 635-640.
11. Gebbia, V.; Zerillo, G.; Restivo, G.; Speciale, R.; Cupido, G.; Lo, Bue, P.; Ingria, F.; Gallina, S.; Spatafora, G.; Testa, A. Chemotherapeutic treatment of recurrent and/or metastatic nasopharyngeal carcinoma: a retrospective analysis of 40 cases. Br. J. Cancer 1993, 68 (1), 191-194.
12. Nabhan, C.; Krett, N.; Gandhi, V.; Rosen, S. Gemcitabine in hematologic malignancies. Curr. Opin. Oncol. 2001, 13 (6), 514-521.
13. Carmichael, J. The role of gemcitabine in the treatment of other tumours. Br. J. Cancer 1998, 78 (Suppl. 3), 21-25.
14. Braakhuis, B.J.M.; Ruiz, van Haperen, V.W.T.; Welters, M.J.P.; Peters, G.J. Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur. J. Cancer 1995, 31A (13-14), 2335-2340.
15. Huisman, C.; Giaccone, G.; van Groeningen, C.J.; Sutedja, G.; Postmus, P.E.; Smit, E.F. Combination of gemcitabine and cisplatin for advanced non-small cell lung cancer: a phase II study with emphasis on scheduling. Lung Cancer 2001, 33 (2-3), 267-275.
16. Philip, P.A.; Zalupski, M.M.; Vaitkevicius, V.K.; Arlauskas, P.; Chaplen, R.; Heilbrun, L.K.; Adsay, V.; Weaver, D.; Shields, A.F. Phase II study of gemcitabine and cisplatin in the treatment of patients with advanced pancreatic carcinoma. Cancer 2001, 92 (3), 569-577.
17. Peters, G.J.; Bergman, A.M.; Ruiz, van Haperen, V.W.; Veerman, G.; Kuiper, C.M.; Braakhuis, B.J. Interaction between cisplatin and gemcitabine in vitro and in vivo. Semin. Oncol. 1995, 22 (4 Suppl. 11), 72-79.
18. Van Moorsel, C.J.; Pinedo, H.M.; Veerman, G.; Bergman, A.M.; Kuiper, C.M.; Vermorken, J.B.; van der Vijgh, W.J.; Peters, G.J. Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines. Br. J. Cancer 1999, 80 (7), 981-990.
19. Lund, B.; Neijt, J.P. Gemcitabine in cisplatin-resistant ovarian cancer. Semin. Oncol. 1996, 23 (5 Suppl. 10), 72-76.
20. Ma, B.B.; Tannock, I.F.; Pond, G.R.; Edmonds, M.R.; Siu, L.L. Chemotherapy with gemcitabine-containing regimens for locally recurrent or metastatic nasopharyngeal carcinoma. Cancer 2002, 95 (12), 2516-2523.
21. Foo, K.F.; Tan, E.H.; Leong, S.S.; Wee, J.T.; Tan, T.; Fong, K.W.; Koh, L.; Tai, B.C.; Lian, L.G.; Machin, D. Gemcitabine in metastatic nasopharyngeal carcinoma of the undifferentiated type. Ann. Oncol. 2002, 13 (1), 150-156.
22. Ngan, R.K.; Yiu, H.H.; Lau, W.H.; Yau, S.; Cheung, F.Y.; Chan, T.M.; Kwok, C.H.; Chiu, C.Y.; Au, S.K.; Foo, W.; Law, C.K.; Tse, K.C. Combination gemcitabine and cisplatin chemotherapy for metastatic or recurrent nasopharyngeal carcinoma: report of a phase II study. Ann. Oncol. 2002, 13 (8), 1252-1258.
23. Soto Parra, H.; Cavina, R.; Latteri, F.; Sala, A.; Dambrosio, M.; Antonelli, G.; Morenghi, E.; Alloisio, M.; Ravasi, G.; Santoro, A. Three-week versus four-week schedule of cisplatin and gemcitabine: results of a randomized phase II study. Ann. Oncol. 2002, 13 (7), 1080-1086.
24. Choo, R.; Tannock, I. Chemotherapy for recurrent or metastatic carcinoma of the nasopharynx. Cancer 1991, 68 (10), 2120-2124.
25. Dugan, M.; Choy, D.; Ngai, A.; Sham, J.; Choi, P.; Shiu, W.; Leung, T.; Leung, T.; Teo, P.; Prasad, U.; Lee, S. Multicenter phase II trial of mitoxantrone in patients with advanced nasopharyngeal carcinoma in Southeast Asia: an Asian-Oceanian Clinical Oncology Association Group study. J. Clin. Oncol. 1993, 11 (1), 70-76.
26. Boussen, H.; Cvitkovic, E.; Wendling, J.L.; Azli, N.; Bachouchi, M.; Mahjoubi, R.; Kalifa, C.; Wibault, P.; Schwaab, G.; Armand, J.P. Chemotherapy of metastatic and/or recurrent undifferentiated nasopharyngeal carcinoma with cisplatin; bleomycin; and fluorouracil. J. Clin. Oncol. 1991, 9 (9), 1675-1681.
27. Teo, P.M.; Kwan, W.H.; Lee, W.Y.; Leung, S.F.; Johnson, P.J. Prognosticators determining survival subsequent to distant metastasis from nasopharyngeal carcinoma. Cancer 1996, 77(12), 2423-2431.
28. Hui, E.P.; Leung, S.F.; Au, J.S.; Zee, B.; Tung, S.; Chua, D.; Sze, W.M.; Law, C.K.; Leung, T.W.; Chan, A.T. Lung metastasis alone in nasopharyngeal carcinoma: a relatively favorable prognostic group. A study by the Hong Kong nasopharyngeal carcinoma study group. Cancer 2004, 101 (2), 300-306.
29. Kurnianda, J.; Pardjono, E.; Adiwiyono, A.; Purwanto, I.; Hariwiyanto, B.; Haryadi, B.; Kusumo, H.; Rahardjo, B.; Buter, J.; Giaccone, G. Combination of gemcitabine and cisplatin (GC) chemotherapy for advanced or recurrent nasopharyngeal cancer (NPC): a phase II study. J. Clin. Oncol. 2004, 22 (14S), 5577 (Meeting Abstracts).
30. Zhang, L.; Guan, Z.Z.; Zhang, Y. Phase II study of gemcitabine single agent for patients with advanced nasopharyngeal carcinoma (NPC) who failed to first line platinum-based chemotherapy. J. Clin. Oncol. 2004, 22 (14S), 5612 (Meeting Abstracts).