Activation of p38 mitogen-activated protein kinase in the early and peak phases of autoimmune neuritis in rat sciatic nerves

Brain Research

Volumn 1040, Issue 1-2, 2005, Pages 208-213

  Moon, Changjong ^a   Ahn, Meejung ^a   Kim, Heechul ^a   Lee, Yongduk ^a   Koh, Chang Sung ^b   Matsumoto, Yoh ^c   Shin, Taekyun ^a  

^a Jeju National University   (South Korea)

^b SHINSHU UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Demyelination; Experimental autoimmune neuritis; p38 MAPK; Sciatic nerve

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BLOOD VESSEL; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MACROPHAGE; NICK END LABELING; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SCHWANN CELL; SCIATIC NERVE; SCIATIC NEUROPATHY; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE; WESTERN BLOTTING;

EID: 16244382069     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.01.089     Document Type: Article

References (16)

1. M. Ahn, C. Moon, Y. Lee, C.S. Koh, K. Kohyama, N. Tanuma, Y. Matsumoto, H.-M. Kim, S.-R. Kim, and T. Shin Activation of extracellular signal-regulated kinases in the sciatic nerves of rats with experimental autoimmune neuritis Neurosci. Lett. 372 2004 57 61
2. C. Bonvin, A. Guillon, M.X. van Bemmelen, P. Gerwins, G.L. Johnson, and C. Widmann Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis Cell Signalling 14 2002 123 131
3. L. Chang, and M.K. Karin Mammalian MAP kinase signaling cascades Nature 410 2001 37 40
4. G. Conti, P.L. Baron, E. Scarpini, C. Vedeler, A. Rostami, D. Pleasure, and G. Scarlato Low-affinity nerve growth factor receptor expression in sciatic nerve during P2-peptide induced experimental allergic neuritis Neurosci. Lett. 199 1995 135 138
5. G. Conti, E. Scarpini, A. Rostami, S. Livraghi, P.L. Baron, D. Pleasure, and G. Scarlato Schwann cell undergoes apoptosis during experimental allergic neuritis (EAN) J. Neurol. Sci. 161 1998 29 35
6. T.P. Garrington, and G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr. Opin. Cell Biol. 11 1999 211 218
7. R. Gold, H.P. Hartung, and K.V. Toyka Animal models for autoimmune demyelinating disorders of the nervous system Mol. Med. Today 6 2000 88 91
8. H.P. Hartung, and K.V. Toyka T-cell and macrophage activation in experimentally induced autoimmune neuritis and Guillain-Barré syndrome Ann. Neurol. 27 1990 S57 S63
9. G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912
10. Y. Lee, and T. Shin Expression of constitutive endothelial and inducible nitric oxide synthase in the sciatic nerve of Lewis rats with experimental autoimmune neuritis J. Neuroimmunol. 126 2002 78 85
11. C. Moon, S. Kim, M. Wie, H. Kim, J. Cheong, J. Park, Y. Jee, N. Tanuma, Y. Matsumoto, and T. Shin Increased expression of p53 and Bax in the spinal cords of rats with experimental autoimmune encephalomyelitis Neurosci. Lett. 289 2000 41 44
12. R.R. Myers, Y. Sekiguchi, S. Kikuchi, B. Scott, S. Medicherla, A. Protter, and W.M. Campana Inhibition of p38 MAP kinase activity enhances axonal regeneration Exp. Neurol. 184 2003 606 614
13. T. Shin, M. Ahn, K. Jung, S. Heo, D. Kim, Y. Jee, Y.K. Lim, and E.J. Yeo Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis J Neuroimmunol. 140 2003 118 125
14. A. Weishaupt, W. Bruck, T. Hartung, K.V. Toyka, and R. Gold Schwann cell apoptosis in experimentally induced autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-alpha Neurosci. Lett. 306 2001 77 80
15. Z. Xia, M. Dickens, J. Raingeaud, R.J. Davis, and M.E. Greenberg Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270 1995 1326 1331
16. U.K. Zettl, R. Gold, H.P. Hartung, and K.V. Toyka Apoptotic cell death of T-lymphocytes in experimental autoimmune neuritis of the Lewis rat Neurosci. Lett. 176 1994 75 79