Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection [2]

Transplantation

Volumn 79, Issue 6, 2005, Pages 736-

  Vu, Minh Diem ^a   Li, Yongsheng ^a   Strom, Terry B ^a   Li, Xian Chang ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CD28 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

DRUG POTENCY; GRAFT REJECTION; GRAFT SURVIVAL; HOST; IMMUNOSTIMULATION; LETTER; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE;

ANIMALS; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; GRAFT REJECTION; GRAFT SURVIVAL; MICE; MODELS, ANIMAL; MYCOPHENOLIC ACID; SKIN TRANSPLANTATION;

EID: 16244371003     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000146966.14808.44     Document Type: Letter

References (5)

1. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
2. Williams MA, Trambley J, Ha J, et al. Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts. J Immunol 2000; 165: 6849.
3. Li Y, Li XC, Zheng XX, et al. Blocking both signal 1 and signal 2 of T cell activation prevents of apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature Med 1999; 5: 1298.
4. Ransom JT. Mechanism of action of mycophenolate mofetil. Ther Drug Monit 1995; 17: 681.
5. Quemeneur L, Flacher M, Gerland LM, et al. Mycophenolic acid inhibits IL-2-dependent T cell proliferation, but not IL-2-dependent survival and sensitization to apoptosis. J Immunol 2002; 169: 2747.