A mathematical model of alveolar gas exchange in partial liquid ventilation

Journal of Biomechanical Engineering

Volumn 127, Issue 1, 2005, Pages 46-59

  Suresh, Vinod ^a   Anderson, Joseph C ^a   Grotberg, James B ^a   Hirschl, Ronald B ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Convection; Gas Exchange; Liquid Breathing; Partial Liquid Ventilation; Perfluorocarbon

Indexed keywords

BLOOD; CARBON DIOXIDE; DIFFUSION; FLUOROCARBONS; MATHEMATICAL MODELS; OSCILLATIONS; PARTIAL PRESSURE; RESPIRATORY SYSTEM; TISSUE; VENTILATION;

MASS CONSERVATION; PARTIAL LIQUID VENTILATION; PERFLUOROCARBON (PFC); RESPIRATORY RATES (RR);

BIOMECHANICS;

CARBON DIOXIDE; FLUOROCARBON; OXYGEN;

ARTICLE; BLOOD GAS; BREATHING RATE; EQUILIBRIUM CONSTANT; FUNCTIONAL RESIDUAL CAPACITY; GAS TRANSPORT; LIQUID VENTILATION; LUNG ALVEOLUS; LUNG GAS EXCHANGE; MATHEMATICAL MODEL; PRESSURE GRADIENT; SOLUBILITY; THERMODYNAMICS; TIDAL VOLUME;

ADULT; COMPUTER SIMULATION; FLUOROCARBONS; HUMANS; LIQUID VENTILATION; MODELS, BIOLOGICAL; OXYGEN; PULMONARY ALVEOLI; PULMONARY GAS EXCHANGE; RESPIRATORY MECHANICS;

EID: 16244366140     PISSN: 01480731     EISSN: None     Source Type: Journal    
DOI: 10.1115/1.1835352     Document Type: Article

References (39)

1. Clark, L. C., and Gollan, F., 1966, "Survival of Mammals Breathing Organic Liquids Equilibrated With Oxygen at Atmospheric Pressure." Science, 152, p. 1755.
2. Curtis, S., Peek, J., and Kelly, D., 1993, "Partial Liquid Breathing With Perflubron Improves Arterial Oxygenation in Acute Canine Lung Injury," J. Appl. Physiol., 75, pp. 2696-2702.
3. Hirschl, R. B. et al., 1995, "Improvement of Gas Exchange, Pulmonary Function, and Lung Injury With Partial Liquid Ventilation. A Study Model in a Setting of Severe Respiratory Failure," Chest, 108, pp. 500-508.
4. Leach, C. L. et al., 1993, "Perfluorocarbon-Associated Gas Exchange (Partial Liquid Ventilation) in Respiratory Distress Syndrome: A Prospective, Randomized, Controlled Study," Crit. Care Med., 21, pp. 1270-1278.
5. Papo, M. C. et al., 1996, "Perfluorocarbon-Associated Gas Exchange Improves Oxygenation, Lung Mechanics, and Survival in a Model of Adult Respiratory Distress Syndrome," Crit. Care Med., 24, pp. 466-474.
6. Quintel, M. et al., 1998, "Computer Tomographic Assessment of Perfluorocarbon and Gas Distribution During Partial Liquid Ventilation for Acute Respiratory Failure," Crit. Care Med., 158, pp. 249-255.
7. Gauger, P. G. et al., 1996, "Initial Experience With Partial Liquid Ventilation in Pediatric Patients With the Acute Respiratory Distress Syndrome," Crit. Care Med., 24, pp. 16-22.
8. Greenspan, J. S. et al., 1999, "Partial Liquid Ventilation in Critically Ill Infants Receiving Extracorporeal Life Support," Pediatrics, 99, p. E2.
9. Hirschl, R. B. et al., 1996, "Initial Experience With Partial Liquid Ventilation in Adult Patients With the Acute Respiratory Distress Syndrome," JAMA, J. Am. Med. Assoc., 275, pp. 383-389.
10. Hirschl, R. B. et al., 2002, "Prospective, Randomized, Controlled Pilot Study of Partial Liquid Ventilation in Adult Acute Respiratory Distress Syndrome," Am. J. Respir. Crit. Care Med., 165, pp. 781-787.
11. Leach, C. L. et al., 1996, "Partial Liquid Ventilation With Perflubron in Premature Infants With Severe Respiratory Distress Syndrome: The LiquiVent Study Group," N. Engl. J. Med., 335, pp. 761-767.
12. Doctor, A. et al., 1998, "Pulmonary Blood Flow Distribution During Partial Liquid Ventilation," J. Appl. Physiol., 84, pp. 1540-1550.
13. Morris, K. P. et al., 2002, "Distribution of Pulmonary Blood Flow in the Perfluorocarbon-Filled Lung," Intensive Care Med., 26, pp. 756-763.
14. Mates, E. A. et al., 1997, "Shunt and Ventilation-Perfusion Distribution During Partial Liquid Ventilation in Healthy Piglets," J. Appl. Physiol., 82, pp. 933-942.
15. Lim, C. M. et al., 2001, "Effect of Increasing Perfluorocarbon Dose on V(Over Dot)A/Q(Over Dot) Distribution During Partial Liquid Ventilation in Acute Lung Injury," Anesthesiology, 94, pp. 637-642.
16. Harris, R. S. et al., 2002, "Regional VA, Q, and VA/Q During PLV: Effects of Nitroprusside and Inhaled Nitric Oxide," J. Appl. Physiol., 92, pp. 297-312.
17. van Lobensels, E. M., Anderson, J. C., Hildebrandt, J., and Hlastala, M. P., 1999, "Modeling Diffusion Limitation of Gas Exchange in Lungs Containing Perfluorocarbon," J. Appl. Physiol., 86, pp. 273-284.
18. Cox, P. N. et al., 1997, "Concealed Air Leak Associated With Large Tidal Volumes in Partial Liquid Ventilation," Am. J. Respir. Crit. Care Med., 156, pp. 992-997.
19. Doctor, A. et al., 2001, "High-Frequency Oscillatory Ventilation of the Perfluorocarbon-Filled Lung: Dose-Response Relationships in an Animal Model of Acute Lung Injury," Crit. Care Med., 29, pp. 847-854.
20. Gothberg, S. et al., 2002, "High-Frequency Oscillatory Ventilation and Partial Liquid Ventilation After Acute Lung Injury in Premature Lambs With Respiratory Distress Syndrome," Crit. Care Med., 28, pp. 2450-2456.
21. Smith, K. M. et al., 1997, "Partial Liquid Ventilation: a Comparison Using Conventional and High-Frequency Techniques in an Animal Model of Acute Respiratory Failure," Crit. Care Med., 25, pp. 1179-1186.
22. Smith, K. M. et al., 1997, "Prolonged Partial Liquid Ventilation Using Conventional and High-Frequency Ventilatory Techniques: Gas Exchange and Lung Pathology in an Animal Model of Respiratory Distress Syndrome," Crit. Care Med., 25, pp. 1888-1897.
23. Sukumar, M. et al., 1998, "High-Frequency Partial Liquid Ventilation in Respiratory Distress Syndrome: Hemodynamics and Gas Exchange," J. Appl. Physiol., 84, pp. 327-334.
24. Gefen, A., Elad, D., and Shiner, R. J., 1999, "Analysis of Stress Distribution in the Alveolar Septa of Normal and Simulated Emphysematic Lungs," J. Biomed. Opt., 32, pp. 891-897.
25. Guyton, A. C., 1986, Textbook of Medical Physiology, 7th ed., W. B. Saunders Company, Philadelphia.
26. 2 Dissociation Computations," J. Appl. Physiol.: Respir., Environ. Exercise Physiol., 46, pp. 599-602.
27. 2 Content," Respir. Physiol., 3, pp. 111.
28. Weibel, E. R., 1963, Morphometry of the Human Lung, Academic, New York, p. 151.
29. Haefeli-Bleuer, B., and Weibel, E. R., 1988, "Morphometry of the Human Pulmonary Acinus," Anat. Rec., 220, pp. 401-414.
30. Hernan, L. J. et al., 1996, "Perfluorocarbon-Associated Gas Exchange in Normal and Acid-Injured Large Sheep," Crit. Care Med., 24, pp. 475-481.
31. Overbeck, M. C. et al., 1996, "Efficacy of Perfluorocarbon Partial Liquid Ventilation in a Large Animal Model of Acute Respiratory Failure," Crit. Care Med., 24, pp. 1208-1214.
32. Baden, H. P. et al., 1997, "High-Frequency Oscillatory Ventilation With Partial Liquid Ventilation in a Model of Acute Respiratory Failure," Crit. Care Med., 25, pp. 299-302.
33. Hoskyns, E. W., Milner, A. D., and Hopkin. I. E., 1992, "Measurement of Tidal Lung Volumes in Neonates During High-Frequency Oscillation," J. Biomed. Eng., 14, pp. 16-20.
34. Scalfaro, P. et al., 2001, "Reliable Tidal Volume Estimates at the Airway Opening With an Infant Monitor During High-Frequency Oscillatory Ventilation," Crit. Care Med., 29, pp. 1925-1930.
35. Lango, T., Morland, T., and Brubakk, A. O., 1996, "Diffusion Coefficients and Solubility Coefficients for Gases in Biological Fluids and Tissues: A Review," Undersea Hyperbaric Med., 23, pp. 247-272.
36. 2 in Fluorinated Ethers," J. Chem. Eng. Data, 18, pp. 411-412.
37. Paiva, M., 1973, "Gas Transport in Human Lung," J. Appl. Physiol., 35, pp. 401-410.
38. Davidson, M. R., and Fitz-Gerald, J. M., 1972, "Flow Patterns in Models of Small Airway Units of Lung," J. Fluid Mech., 52, p. 161.
39. Wei, H. H., and Grotberg, J. B., "Flow and Transport in a Rhythmically Breathing Alveolus Partially Filled With Liquid," Phys. Fluids (Submitted).