Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease

Journal of Small Animal Practice

Volumn 46, Issue 3, 2005, Pages 121-130

  Smith, P J ^a,e   French, A T ^a   Van Israel N ^a,f   Smith, S G W ^b   Swift, S T ^c   Lee, A J ^d   Corcoran, B M ^a   Dukes McEwan, J ^a,g  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Derby   (United Kingdom)

^c Cheadle Hulme Veterinary Hospital   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e Martin Referral Services   (United Kingdom)

^f Animal Cardiopulmonary Consultancy   (Belgium)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; PIMOBENDAN; RAMIPRIL; VASODILATOR AGENT; VASOTOP; VETMEDIN; CARDIOTONIC AGENT; PYRIDAZINE DERIVATIVE;

ANIMAL LAMENESS; ARTICLE; ASCITES; COLLAPSE; CONFIDENCE INTERVAL; CONFUSION; CONTROLLED STUDY; DIARRHEA; DOG; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HEART FAILURE; HEART SUPRAVENTRICULAR ARRHYTHMIA; MALE; MITRAL VALVE DISEASE; NONHUMAN; OUTCOMES RESEARCH; POLYDIPSIA; PRURITUS; RASH; RISK; SNEEZING; TREATMENT FAILURE; VOMITING; ANIMAL; ANIMAL DISEASE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; DOG DISEASE; ELECTROCARDIOGRAPHY; MITRAL VALVE; MITRAL VALVE REGURGITATION; PATHOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SAFETY; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME;

ANIMALIA; CANIS FAMILIARIS;

ANIMALS; CARDIOTONIC AGENTS; DOG DISEASES; DOGS; ELECTROCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; MITRAL VALVE; MITRAL VALVE INSUFFICIENCY; ODDS RATIO; PROSPECTIVE STUDIES; PYRIDAZINES; RAMIPRIL; SAFETY; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 15944422122     PISSN: 00224510     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-5827.2005.tb00302.x     Document Type: Article

References (34)

1. BENCH STUDY GROUP (1999) The effect of benazepril on survival times and clinical signs of dogs with congestive heart failure: results of a multicenter, prospective, randomized, double-blinded, placebo-controlled, long-term clinical trial. Journal of Veterinary Cardiology 1, 7-18
2. CORSINI, W. A., HOOK, J. B. & BAILIE, M. D. (1975) Control of renin secretion in the dog. Effects of furosemide on the vascular and mascula densa receptors. Circulation Research 37, 464-470
3. COVE STUDY GROUP (1995) Controlled clinical evaluation of enalapril in dogs with heart failure: results of the Cooperative Veterinary Enalapril Study Group. Journal of Veterinary Internal Medicine 9, 243-252
4. DARKE, P. G. G. (1995) Mitral valve disease in Cavalier King Charles Spaniels. In: Kirk's Current Veterinary Therapy. 12th edn. Eds J. D. Bonagura and R. W. Kirk. W. B. Saunders, Philadelphia, pp 837-841
5. DUKES-MCEWAN, J., FRENCH, A. T. & CORCORAN, B. M. (2002) Doppler echocardiography in the dog: measurement variability and reproducibility. Veterinary Radiology & Ultrasound 43, 154-165
6. ECKBERG, D. L., GUALT, J. H., BOUCHARD, R. L., KARLINER, J. S. & Ross, R. (1973) Mechanics of left ventricular contraction in chronic severe mitral regurgitation. Circulation XLVII, 1252-1259
7. ENRIQUEZ-SARANO, M., BASMADJIAN, A-J., ROSSI, A., BAILEY, K. R., SEWARD, J. B. & TAJIK, A. J. (1999) Progression of mitral regurgitation. Journal of the American College of Cardiology 34, 1137-1144
8. EPOCH STUDY GROUP (2002) Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure. Circulation 66, 149-157
9. ERLEMEIER, H. H., KUPPER, W. & BLEIFELD, W. (1991) Comparison of hormonal and haemodynamic changes after long-term oral therapy with pimobendan or enalapril - a double-blind randomized study. European Heart Journal 12, 889-899
10. FITTON, A. & BROGDEN, R. N. (1994) Pimobendan. A review of its pharmacology and therapeutic potential in congestive heart failure. Drugs and Aging 4, 417-441
11. HAGGSTROM, J., HASSON, K. & KVART, C. (1992) Chronic valvular disease in the Cavalier King Charles spaniel in Sweden. Veterinary Record 131, 549
12. HAMLIN, R. L. & NAKAYAMA, T. (1998) Comparison of some pharmacokinetic parameters of 5 angiotensin-converting enzyme inhibitors in normal beagles. Journal of Veterinary Internal Medicine 12, 93-95
13. IMPROVE STUDY GROUP (1995) Acute and short-term haemodynamic, echocardiographic, and clinical effects of enalapril maleate in dogs with naturally acquired heart failure: results of the invasive multicenter prospective veterinary evaluation of enalapril study. Journal of Veterinary Internal Medicine 9, 234-242
14. KIRKWOOD, B. R. & STERNE, J. A. C. (2003) Link analysis to study design: summary of methods. In: Essential Medical Statistics. 2nd edn. Blackwell Science, Massachusetts, p 401
15. KITTLESON, M. D., EYSTER, G. E., KNOWLEN, G. G., OLIVIER, N. B. & ANDERSON, L. K. (1984) Myocardial function in small dogs with chronic mitral regurgitation and severe congestive heart failure. Journal of the American Veterinary Medical Association 184, 455-459
16. KITTLESON, K. D. & KIENLE, R. D. (1998a) Myxomatous atrioventricular valvular degeneration. In: Small Animal Cardiovascular Medicine. Eds M. D. Kittleson, P. Pion, R. Kienle and L. Duncan. Mosby, USA. p 304
17. KITTLESON, K. D. & KIENLE, R. D. (1998b) Pathophysiology of heart failure. In: Small Animal Cardiovascular Medicine. Eds M. D. Kittleson, P. Pion, R. Kienle and L. Duncan. Mosby, USA. p 140
18. KVART, C., HAGGSTROM, J., PEDERSON, J. K., HANSSON, K., ERIKSSON, A., JARVINEN, A-K., TIDHOLM, A., BSENKO, K., AHLGREN, E., ILVES, M., ABLAD, B., FALK, T., BJERKAS, E., GUNDLER, S., LORD, P., WEGELAND, G., ADOLFSSON, E. & CORFITZEN, J. (2002) Efficacy of enalapril for prevention of congestive heart failure in dogs with myxomatous valve disease and asymptomatic mitral regurgitation. Journal of Veterinary Internal Medicine 16, 80-88
19. LIVE STUDY GROUP (1998) Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. Journal of the American Veterinary Medical Association 213, 1573-1577
20. LOMBARD, C. W. (2000) Clinical experience with pimobendan. Proceedings of the Veterinary Cardiovascular Society Pre-BSAVA Meeting. Birmingham, April.
21. LORD, P., ERIKSSON, A., HAGGSTROM, J., JARVINEN, A-K. & KVART, C. (2003) Increased pulmonary transit times in dogs with mitral regurgitation indicate decreased pump function before failure. Journal of Veterinary Internal Medicine 17, 824-829
22. LUIS FUENTES, V., CORCORAN, B., FRENCH, A., SCHOBER, K. E., KLEEMAN, R. & JUSTUS, C. (2002) A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy. Journal of Veterinary Internal Medicine 16, 255-261
23. LYNCH, J. J., KITZEN, J. M., HOFF, P. T. & LUCCHESI, B. R. (1988) Effects of pimobendan (UD-CG 115 BS), a new positive inotropic agent, on ventricular tachycardia and ischaemic ventricular fibrillation in a conscious model of recent myocardial infarction. Journal of Cardiovascular Pharmacology 12, 547-554
24. MATHEW, L. & KATZ, S. D. (1998) Calcium sensitizing agents in heart failure. Drugs and Aging 12, 191-204
25. NAGATSU, M., ZILE, M. R., TSUTSUI, H., SCHMID, P. G., DEFREYTE, G., COOPER, G. & CARABELLO, B. A. (1994) Native β-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function. Circulation 89, 818-826
26. O'ROURKE, R. A., HANRATH, P., HENRY, W. N. & HUGENHOLTZ, P. G. (1984) Report of the Joint International Society and Federation of Cardiology/World Health Organization Task Force on recommendations for standardization of measurements from M-mode echocardiograms. Circulation 69, 854A-857A
27. i. Molecular Pharmacology 33, 441-448
28. PICO INVESTIGATORS (1996) Effect of pimobendan on exercise capacity in patients with heart failure: main results from the pimobendan in congestive heart failure (PICO) trial. Heart 76, 223-231
29. SCHILLER, N. B. (1991) Two-dimensional echocardiographic determination of left ventricular volume, systolic function and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography. Circulation 84, 1280-1287
30. SCHILLER, N. B. & FOSTER, E. (1996) Analysis of left ventricular systolic function. Heart 75, 17-26
31. SCHILLER, N. B., SHAH, P. M., CRAWFORD, M., DEMARIA, A., DEVEREUX, R., FEIGENBAUM, H., GUTGESELL, H., REICHEK, N., SAHN, D. & SCHNITTGER, I. (1989) Recommendations for quantification of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantification of Two-Dimensional Echocardiograms. Journal of the American Society of Echocardiography 2, 358-367
32. 2+ sensitivity induced by UD-CG 212 Cl, an active metabolite of pimobendan, in canine ventricular myocardium. Journal of Cardiovascular Pharmacology 37, 209-218
33. THOMAS, W. P., GABER, C. E., JACOBS, G. J., KAPLAN, P. M., LOMBARD, C. W., MOISE, N. S. & MOSES, B. L. (1993) Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Journal of Veterinary Internal Medicine 7, 247-252
34. URABE, Y., MANN, L., KENT, R. L., NAKANO, K., TOMANEK, R. J., CARABELLO, B. A. & COOPER, G. (1992) Cellular and ventricular contractile dysfunction in experimental canine mitral regurgitation. Circulation Research 70, 131-147