Hematopoietic deficiencies and core binding factor expression in murine Ts16, an animal model for down syndrome

Clinical Immunology

Volumn 91, Issue 1, 1999, Pages 50-60

  Gjertson, Carl ^a   Sturm, Karin S ^a   Berger, Christoph N ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Alternative mRNA transcripts; Core binding factor; Down syndrome; Hematopoietic precursor cells; Murine Ts16

Indexed keywords

COMPLEMENTARY DNA; DNA BINDING PROTEIN; ONCOPROTEIN; PRIMER DNA; RUNX1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX1;

ANIMAL; ARTICLE; C57BL MOUSE; CELL LINE; DISEASE MODEL; DOWN SYNDROME; FEMALE; FETUS; GENE EXPRESSION; GENETICS; HEMATOPOIESIS; HEMATOPOIETIC SYSTEM; HUMAN; IMMUNOLOGY; MALE; MOUSE; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT;

ANIMALS; BASE SEQUENCE; CELL LINE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DISEASE MODELS, ANIMAL; DNA PRIMERS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOWN SYNDROME; FEMALE; FETUS; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC SYSTEM; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; PREGNANCY; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 15944388640     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.1998.4685     Document Type: Article

References (52)

1. Epstein, C. J., "The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models." Cambridge Univ. Press, Cambridge, 1986.
2. Murphy, M., and Epstein, L. B., Down syndrome (DS) peripheral blood contains phenotypically mature CD3 + TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS thymus. Clin. Immunol. Immunopathol. 62, 245-251, 1992.
3. Murphy, M., Insoft, R. M., Pike-Nobile, L., Derbin, K. S., and Epstein, L. B., Overexpression of LEA-1 and ICAM-1 in Down syndrome thymus. Implications for abnormal thymocyte maturation. J. Immunol. 150, 5696-5703, 1993.
4. Stewart, A., Webb, J., and Hewitt, D., A survey of childhood malignancies. Br. Med. J. 1, 1495-1508, 1985.
5. Fong, C., and Brodeur, G. M., Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet. Cytogenet. 28, 55-76, 1987.
6. Epstein, C. J., Hofmeister, B. G., Yee, D., Smith, S. A., Philip, R., Cox, D. R., and Epstein, L. B., Stem cell deficiencies and thymic abnormalities in fetal mouse trisomy 16. J. Exp. Med. 162, 695-712, 1985.
7. Berger, C. N., Huang, T.-T., and Epstein, C. J., Mouse models of human Trisomy 21 (Down syndrome). In "Genetically Defined Animal Models of Neurobehavioral Dysfunction" (P. Driscoll, Ed.). Birkhäuser, Boston, 1990.
8. Lyon, M. F., Cocking, Y., and Gao, X., Mouse chromosome atlas. Mouse Genome 95, 29-77, 1997.
9. Nucifora, G., Begy, C. R., Erickson, P., Drabkin, H. A., and Rowley, J. D., The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. Proc. Natl. Acad. Sci. USA 90, 7784-7788, 1993.
10. Miyoshi, H., Kozu, T., Shimizu, K., Enomoto, K., Maseki, N., Kaneko, Y., Kamada, N., and Ohki, M., The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J. 12, 2715-2721, 1993.
11. Mitani, K., Ogawa, S., Tanaka, T., Miyoshi, H., Kurokawa, M., Mano, H., Yazaki, Y., Ohki, M., and Hirai, H., Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J. 13, 504-510, 1994.
12. Romana, S. P., Mauchauffe, M., Le Coniat, M., Chumakov, I., Le Paslier, D., Berger, R., and Bernard, O. A., The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85, 3662-3670, 1995.
13. Kurokawa, M., Tanaka, T., Tanaka, K., Ogawa, S., Mitani, K., Yazaki, Y., and Hirai, H., Overexpression of the AML1 protooncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies. Oncogene 12, 883-892, 1996.
14. Kamachi, Y., Ogawa, E., Asano, M., Ishida, S., Murakami, Y., Satake, M., Ito, Y., and Shigesada, K., Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64, 4808-4819, 1990.
15. Wijmenga, C., Speck, N. A., Dracopoli, N. C., Hofker, M. H., Liu, P., and Collins, F. S., Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. Genomics 26, 611-614, 1995.
16. Levanon, D., Negreanu, V., Bernstein, Y., Bar Am, I., Avivi, L., and Groner, Y., AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics 23, 425-432, 1994.
17. Bae, S. C., Ogawa, E., Maruyama, M., Oka, H., Satake, M., Shigesada, K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Ito, Y., PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol. Cell. Biol. 14, 3242-3252, 1994.
18. Kryszke, M. H., Piette, J., and Yaniv, M., Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells. Nature 328, 254-256, 1987.
19. Piette, J., and Yaniv, M., Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also inter-acts with the SV40 and c-fos enhancers. EMBO J. 6, 1331-1337, 1987.
20. Bae, S. C., Yamaguchi Iwai, Y., Ogawa, E., Maruyama, M., Inuzuka, M., Kagoshima, H., Shigesada, K., Satake, M., and Ito, Y., Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene 8, 809-814, 1993.
21. Tanaka, K., Tanaka, T., Ogawa, S., Kurokawa, M., Mitani, K., Yazaki, Y., and Hirai, H., Increased expression of AML1 during retinoic-acid-induced differentiation of U937 cells. Biochem. Biophys. Res. Commun. 211, 1023-1030, 1995.
22. Zhang, Y. W., Bae, S. C., Huang, G., Fu, Y. X., Lu, J., Ahn, M. Y., Kanno, Y., Kanno, T., and Ito, Y., A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dc13 myeloid cells. Mol. Cell. Biol. 17, 4133-4145, 1997.
23. Meyers, S., Lenny, N., and Hiebert, S. W., The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Mol. Cell. Biol. 15, 1974-1982, 1995.
24. Zhang, D. E., Hohaus, S., Voso, M. T., Chen, H. M., Smith, L. T., Hetherington, C. J., and Tenen, D. G., Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters. Curr. Topics Microbiol. Immunol. 211, 137-147, 1996.
25. Uchida, H., Zhang, J., and Nimer, S. D., AML1A and AML1B can transactivate the human IL-3 promoter. J. Immunol. 158, 2251-2258, 1997.
26. Frank, R., Zhang, J., Uchida, H., Meyers, S., Hiebert, S. W., and Nimer, S. D., The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 11, 2667-2674, 1995.
27. Takahashi, A., Satake, M., Yamaguchi Iwai, Y., Bae, S. C., Lu, J., Maruyama, M., Zhang, Y. W., Oka, H., Arai, N., Arai, K., et al., Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood 86, 607-616, 1995.
28. Klampfer, L., Zhang, J., Zelenetz, A. O., Uchida, H., and Nimer, S. D., The AML1/ETO fusion protein activates transcription of BCL-2. Proc. Natl. Acad. Sci. USA 93, 14059-14064, 1996.
29. Nuchprayoon, I., Meyers, S., Scott, L. M., Suzow, J., Hiebert, S., and Friedman, A. D., PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol. 14, 5558-5568, 1994.
30. Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T. L., Huang, X., Bushweller, J. H., Bories, J. C., Alt, F. W., Ryan, G., Liu, P. P., Wynshaw-Boris, A., Binder, M., Marin-Padilla, M., Sharpe, A. H., and Speck, N. A., The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 87, 697-708, 1996.
31. Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., and Speck, N. A., Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Natl. Acad. Sci. USA 93, 3444-3449, 1996.
32. Berger, C. N., and Epstein, C. J., Delayed thymocyte maturation in the trisomy 16 mouse fetus. J. Immunol. 143, 389-396, 1989.
33. Berger, C. N., and Sturm, K. S., Estimation of the number of hematopoietic precursor cells during fetal mouse development by covariance analysis. Blood 88, 2502-2509, 1996.
34. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., and Papaioannou, V. E., RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877, 1992.
35. Wang, B., Biron, C., She, J., Higgins, K., Sunshine, M. J., Lacy, E., Lonberg, N., and Terhorst, C., A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc. Natl. Acad. Sci. USA 91, 9402-9406, 1994.
36. Kasai, M., Hirokawa, K., Kajino, K., Ogasawara, K., Tatsumi, M., Hermel, E., Monaco, J. J., and Mizuochi, T., Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur. J. Immunol. 26, 2101-2107, 1996.
37. Unkeless, J. C., Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150, 580-596, 1979.
38. Berger, C. N., and Sturm, K. S., Self renewal of embryonic stem cells in the absence of feeder cells and exogenous leukaemia inhibitory factor. Growth Factors 14, 145-159, 1997.
39. Tomida, M., Yamamoto-Yamaguchi, Y., and Hozumi, M., Purification of a factor inducing differentiation of mouse myeloid leukemia Ml cells from conditioned medium of mouse fibroblast L929 cells. J. Biol. Chem. 259, 10978-10982, 1984.
40. Laskov, R., Kim, J. K., Woods, V. L., McKeever, P. E., and Asofsky, R., Membrane immunoglobulins of spontaneous B lymphomas of aged BALB/c mice. Eur. J. Immunol. 11, 462-468, 1981.
41. Groettrup, M., Baron, A., Griffiths, G., Palacios, R., and von Boehmer, H., T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. EMBO J. 11, 2735-2745, 1992.
42. Hyman, R., and Stallings, V., Characterization of a TL- variant of a homozygous TL+ mouse lymphoma. Immunogen. 3, 75-84, 1976.
43. Berger, C. N., Tan, S.-S., and Sturm, K. S., Simultaneous detection of β-galactosidase activity and surface antigen expression in viable haematopoietic cells. Cytometry 17, 216-223, 1994.
44. Dudov, K. P., and Perry, R. P., The gene family encoding the mouse ribosomal protein L32 contains a uniquely expressed intron-containing gene and an unmutated processed gene. Cell 37, 457-468, 1984.
45. Petersen, M. B., Antonarakis, S. E., Hassold, T. J., Freeman, S. B., Sherman, S. L., Avramopoulos, D., and Mikkelsen, M., Paternal nondisjunction in trisomy 21: Excess of male patients. Hum. Mol. Genet. 2, 1691-1695, 1993.
46. Moore, M. A. S., and Metcalf, D., Ontogeny of the haematopoietic system: Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br. J. Haematol. 18, 279-296, 1970.
47. Medvinsky, A., and Dzierzak, E., Definitive hematopoiesis is autonomously initiated by the AGM region. Cell 86, 897-906, 1996.
48. Cumano, A., Dieterlen-Lievre, F., and Godin, I., Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell 86, 907-916, 1996.
49. Yoder, M. C., Hiatt, K., Dutt, P., Mukherjee, P., Bodine, D. M., and Orlic, D., Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac. Immunity 7, 335-344, 1997.
50. Tanaka, T., Tanaka, K., Ogawa, S., Kurokawa, M., Mitani, K., Nishida, J., Shibata, Y., Yazaki, Y., and Hirai, H., An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J. 14, 341-350, 1995.
51. Holtzman, D. M., Bayney, R. M., Li, Y., Khosrovi, H., Berger, C. N., Epstein, C. J., and Mobley, W. C., Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. EMBO J. 11, 619-627, 1992.
52. Miyoshi, H., Ohira, M., Shimizu, K., Mitani, K., Hirai, H., Imai, T., Yokoyama, K., Soeda, E., and Ohki, M., Alternative splicing and genomic structure of the AML1 gene involved in acute my eloid leukemia. Nucl. Acid Res. 23, 2762-2769, 1995.