-
1
-
-
0142184371
-
Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 a mutation and in heterozygous FII single gene mutation alone
-
Samama M, Rached R, Horellou M, et al. Pregnancy-associated venous thromboembolism (VTE) in combined heterozygous factor V Leiden (FVL) and prothrombin (FII) 20210 A mutation and in heterozygous FII single gene mutation alone. Br J Haematol 2003; 123:327-334. A cohort study of a small series of women (n = 119) with an identified thrombophilia. It reports an increased risk of pregnancy-associated VTE among women with combined mutations.
-
(2003)
Br J Haematol
, vol.123
, pp. 327-334
-
-
Samama, M.1
Rached, R.2
Horellou, M.3
-
2
-
-
0242333862
-
Factor V Leiden, prothrombin 20210G > A, methylenetetrahydrofolate reductase 677C > T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism
-
Meglic L, Stegnar M, Milanez T, et al. Factor V Leiden, prothrombin 20210G > A, methylenetetrahydrofolate reductase 677C > T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism. Eur J Obstet Gynecol Reprod Biol 2003; 111:157-163. A small, retrospective case-control study reporting an association between inherited thrombophilia and pregnancy-related VTE.
-
(2003)
Eur J Obstet Gynecol Reprod Biol
, vol.111
, pp. 157-163
-
-
Meglic, L.1
Stegnar, M.2
Milanez, T.3
-
3
-
-
0038299175
-
Effect of hemostatic risk factors on the individual probability of thrombosis during pregnancy and the puerperium
-
Gerhardt A, Scharf R, Zotz R. Effect of hemostatic risk factors on the individual probability of thrombosis during pregnancy and the puerperium. Thromb Haemost 2003; 90:77-85. This study reports and association between VTE and inherited thrombophilia.
-
(2003)
Thromb Haemost
, vol.90
, pp. 77-85
-
-
Gerhardt, A.1
Scharf, R.2
Zotz, R.3
-
4
-
-
0034610031
-
Mutations in coagulation factors in women with unexplained late fetal loss
-
Martinelli I, Taioli E, Cetin I, et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000; 343:1015-1018.
-
(2000)
N Engl J Med
, vol.343
, pp. 1015-1018
-
-
Martinelli, I.1
Taioli, E.2
Cetin, I.3
-
5
-
-
0242579374
-
Antiphospholipid antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: A matched case-control study
-
Gris J, Perneger T, Quere I, et al. Antiphospholipid antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study. Blood 2003; 102:3504-3513. A well designed study reporting that first early pregnancy loss is associated with increased levels of autoantibodies.
-
(2003)
Blood
, vol.102
, pp. 3504-3513
-
-
Gris, J.1
Perneger, T.2
Quere, I.3
-
6
-
-
1842637313
-
The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis
-
Dudding T, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004; 91:700-711. An excellent and comprehensive systematic review on the risk of FVL in pregnancy. It ties together the findings of numerous small studies to quantify the risk of suffering an adverse pregnancy complication in women with this hereditary polymorphism.
-
(2004)
Thromb Haemost
, vol.91
, pp. 700-711
-
-
Dudding, T.1
Attia, J.2
-
7
-
-
0141763739
-
Factor V Leiden and the risk of stillbirth in a German population
-
Volzke H, Grimm R, Robinson D, et al. Factor V Leiden and the risk of stillbirth in a German population. Thromb Haemost 2003; 90:429-433. A large, population-based analysis that examined the risk of stillbirth in German women with thrombophilia.
-
(2003)
Thromb Haemost
, vol.90
, pp. 429-433
-
-
Volzke, H.1
Grimm, R.2
Robinson, D.3
-
8
-
-
0346997966
-
Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: A multicentre study
-
Hefler L, Jirecek S, Heim K, et al. Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicentre study. J Soc Gynecol Investig 2004; 11:42-44. Small study which found no relationship between thrombophilic polymorphisms and intrauterine fetal death. Authors failed to state what intrauterine fetal death definition they used for their study.
-
(2004)
J Soc Gynecol Investig
, vol.11
, pp. 42-44
-
-
Hefler, L.1
Jirecek, S.2
Heim, K.3
-
9
-
-
1642464703
-
Thrombophilia is not associated with an increase in placental abnormalities in women with intra-uterine fetal death
-
Morssink L, Santema J, Willemse F. Thrombophilia is not associated with an increase in placental abnormalities in women with intra-uterine fetal death. Acta Obstet Gynecol Scand 2004; 83:348-350. This small study failed to demonstrate an association between the presence of thrombophilic factors and pregnancies ending in intrauterine fetal death.
-
(2004)
Acta Obstet Gynecol Scand
, vol.83
, pp. 348-350
-
-
Morssink, L.1
Santema, J.2
Willemse, F.3
-
10
-
-
0030940343
-
First-trimester repeated abortion is not associated with activated protein C resistance
-
Balasch J, Reverter JC, Fabregues F, et al. First-trimester repeated abortion is not associated with activated protein C resistance. Hum Reprod 1997; 12:1094-1097.
-
(1997)
Hum Reprod
, vol.12
, pp. 1094-1097
-
-
Balasch, J.1
Reverter, J.C.2
Fabregues, F.3
-
11
-
-
0035017316
-
Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage
-
Rai R, Shlebak A, Cohen H, et al. Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage. Hum Reprod 2001; 16:961-965.
-
(2001)
Hum Reprod
, vol.16
, pp. 961-965
-
-
Rai, R.1
Shlebak, A.2
Cohen, H.3
-
12
-
-
0033964464
-
Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy
-
Murphy RP, Donoghue C, Nallen RJ, et al. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in pregnancy. Arterioscler Thromb Vasc Biol 2000; 20:266-270.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 266-270
-
-
Murphy, R.P.1
Donoghue, C.2
Nallen, R.J.3
-
13
-
-
0343092039
-
Factor V Leiden as a risk factor for miscarriage and reduced fertility
-
Bare SN, Poka R, Balogh I, Ajzner E. Factor V Leiden as a risk factor for miscarriage and reduced fertility. Aust N Z J Obstet Gynecol 2000; 40:186-190.
-
(2000)
Aust N Z J Obstet Gynecol
, vol.40
, pp. 186-190
-
-
Bare, S.N.1
Poka, R.2
Balogh, I.3
Ajzner, E.4
-
14
-
-
0033973640
-
Activated protein C resistance and factor V Leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss
-
Younis JS, Brenner B, Ohel G, et al. Activated protein C resistance and factor V Leiden mutation can be associated with first- as well as second-trimester recurrent pregnancy loss. Am J Reprod Immunol 2000; 43:31-35.
-
(2000)
Am J Reprod Immunol
, vol.43
, pp. 31-35
-
-
Younis, J.S.1
Brenner, B.2
Ohel, G.3
-
15
-
-
0033955432
-
Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages
-
Foka ZJ, Lambropoulos AF, Saravelos H, et al. Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod 2000; 15:458-462.
-
(2000)
Hum Reprod
, vol.15
, pp. 458-462
-
-
Foka, Z.J.1
Lambropoulos, A.F.2
Saravelos, H.3
-
16
-
-
0030928377
-
Factor V Leiden is associated with repeated and recurrent unexplained fetal losses
-
Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost 1997; 77:822-824.
-
(1997)
Thromb Haemost
, vol.77
, pp. 822-824
-
-
Grandone, E.1
Margaglione, M.2
Colaizzo, D.3
-
17
-
-
0035139803
-
Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss
-
Raziel A, Kornberg Y, Friedler S, et al. Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss. Am J Reprod Immunol 2001; 45:65-71.
-
(2001)
Am J Reprod Immunol
, vol.45
, pp. 65-71
-
-
Raziel, A.1
Kornberg, Y.2
Friedler, S.3
-
18
-
-
0034919759
-
Thrombophilic gene mutations and recurrent spontaneous abortion: Prothrombin mutation increases the risk in the first trimester
-
Pihusch R, Buchholz T, Lohse P, et al. Thrombophilic gene mutations and recurrent spontaneous abortion: prothrombin mutation increases the risk in the first trimester. Am J Reprod Immunol 2001; 46:124-131.
-
(2001)
Am J Reprod Immunol
, vol.46
, pp. 124-131
-
-
Pihusch, R.1
Buchholz, T.2
Lohse, P.3
-
19
-
-
1542287296
-
Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: A meta-analysis
-
Kovalevsky G, Gracia C, Berlin J, et al. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Int Med 2004; 164:558-563. An exceptionally well executed systematic review with very important information on the risk of recurrent pregnancy loss with hereditary thrombophilias.
-
(2004)
Arch Int Med
, vol.164
, pp. 558-563
-
-
Kovalevsky, G.1
Gracia, C.2
Berlin, J.3
-
20
-
-
0038300096
-
Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage
-
Hohlagschwandtner M, Unfried G, Heinze G, et al. Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage. Fertil Steril 2003; 79:1141-1148. A well executed study that presents detailed results and a statistical analysis.
-
(2003)
Fertil Steril
, vol.79
, pp. 1141-1148
-
-
Hohlagschwandtner, M.1
Unfried, G.2
Heinze, G.3
-
21
-
-
0041767403
-
Association of Leiden mutation in factor V gene with hypertension in pregnancy and pre-eclampsia: A meta-analysis
-
Kosmas I, Tatsioni A, Ioannidis J. Association of Leiden mutation in factor V gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. J Hypertens 2003; 21:1221-1228. A comprehensive metaanalysis investigating the role of FVL in hypertension in pregnancy. Authors investigate results fully and advise how to interpret results of a systematic review.
-
(2003)
J Hypertens
, vol.21
, pp. 1221-1228
-
-
Kosmas, I.1
Tatsioni, A.2
Ioannidis, J.3
-
22
-
-
0036253127
-
Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: Results from a large population-based study and systematic review
-
Morrison ER, Miedzybrodzka ZH, Campbell DM, et al. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Thromb Haemost 2002; 87:779-785.
-
(2002)
Thromb Haemost
, vol.87
, pp. 779-785
-
-
Morrison, E.R.1
Miedzybrodzka, Z.H.2
Campbell, D.M.3
-
23
-
-
1642504829
-
Ethnic differences in the association of factor V Leiden mutation and the C677T methylene-tetrahydrofolate reductase gene polymorphism with preeclampsia
-
Prasmusinto D, Skrablin S, Fimmers R, van der Ven K. Ethnic differences in the association of factor V Leiden mutation and the C677T methylene-tetrahydrofolate reductase gene polymorphism with preeclampsia. Eur J Obstet Gynecol Reprod Biol 2004; 112:162-169. A relatively small case-control study that examined the risk of preeclampsia and inherited thrombophilia in two different ethnic populations.
-
(2004)
Eur J Obstet Gynecol Reprod Biol
, vol.112
, pp. 162-169
-
-
Prasmusinto, D.1
Skrablin, S.2
Fimmers, R.3
Van Der Ven, K.4
-
24
-
-
17944398370
-
Factor V Leiden in pregnancies complicated by placental abruption
-
Prochazka M, Happach C, Marsal K, et al. Factor V Leiden in pregnancies complicated by placental abruption. BJOG 2003; 110:462-466. Retrospective study that does not exclude women with other adverse pregnancy complications.
-
(2003)
BJOG
, vol.110
, pp. 462-466
-
-
Prochazka, M.1
Happach, C.2
Marsal, K.3
-
25
-
-
0038743409
-
Inherited thrombophilias are not increased in 'idiopathic' small-for-gestational-age pregnancies
-
McCowan L, Craigie S, Taylor R, et al. Inherited thrombophilias are not increased in 'idiopathic' small-for-gestational-age pregnancies. Am J Obstet Gynecol 2003; 188:981-985. Case-control study reporting no increase in thrombophilia in women with IUGR pregnancies. First study to investigate the prevalence of inherited thrombophilias in IUGR babies and mothers.
-
(2003)
Am J Obstet Gynecol
, vol.188
, pp. 981-985
-
-
McCowan, L.1
Craigie, S.2
Taylor, R.3
-
26
-
-
0042877163
-
Association of maternal and/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction
-
Schlembach D, Beinder E, Zingsem J, et al. Association of maternal and/or fetal factor V Leiden and G20210A prothrombin mutation with HELLP syndrome and intrauterine growth restriction. Clin Sci 2003; 105:279-285. Examines the association of IUGR and inherited thrombophilias. Almost half of the cases also have HELLP syndrome.
-
(2003)
Clin Sci
, vol.105
, pp. 279-285
-
-
Schlembach, D.1
Beinder, E.2
Zingsem, J.3
-
27
-
-
0037704395
-
Inherited thrombophilias and anticoagulation in pregnancy
-
Bowles L, Cohen H. Inherited thrombophilias and anticoagulation in pregnancy. Best Pract Res Clin Obstet Gynaecol 2003; 17:471-489. Authors discuss anticoagulation for women with inherited thrombophilic disorders, define criteria for thromboprophylaxis and explore other therapeutic options for the management of thrombophilia in pregnancy.
-
(2003)
Best Pract Res Clin Obstet Gynaecol
, vol.17
, pp. 471-489
-
-
Bowles, L.1
Cohen, H.2
-
28
-
-
0033901546
-
Thrombophilia in pregnancy
-
Walker ID. Thrombophilia in pregnancy. J Clin Pathol 2000; 53:573-580.
-
(2000)
J Clin Pathol
, vol.53
, pp. 573-580
-
-
Walker, I.D.1
-
29
-
-
0034791001
-
Investigation and management of heritable thrombophilia
-
Walker ID, Greaves M, Preston FE, on behalf of the Haemostasis and Thrombosis Task Force British Committee for Standards in Haematology. Investigation and management of heritable thrombophilia. Br J Haematol 2001; 114:512-528.
-
(2001)
Br J Haematol
, vol.114
, pp. 512-528
-
-
Walker, I.D.1
Greaves, M.2
Preston, F.E.3
-
31
-
-
2342637715
-
Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - No
-
Middeldorp S. Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - no. J Thromb Haemost 2003; 1:2073-2074. Short review article highlighting the need for further placebo-controlled trials to determine the most effective therapeutic regimen in preventing recurrent pregnancy loss in women with thrombophilia.
-
(2003)
J Thromb Haemost
, vol.1
, pp. 2073-2074
-
-
Middeldorp, S.1
-
32
-
-
0037334440
-
Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies
-
Triolo G, Ferrante A, Ciccia F, et al. Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis Rheum 2004; 48:728-731.
-
(2004)
Arthritis Rheum
, vol.48
, pp. 728-731
-
-
Triolo, G.1
Ferrante, A.2
Ciccia, F.3
-
33
-
-
0029790186
-
Randomized trial of aspirin versus aspirin and heparin in pregnant women with the antiphospholipid syndrome
-
Cohen H. Randomized trial of aspirin versus aspirin and heparin in pregnant women with the antiphospholipid syndrome. Ann Med Interne (Paris) 1996; 147 (Suppl).
-
(1996)
Ann Med Interne (Paris)
, vol.147
, Issue.SUPPL.
-
-
Cohen, H.1
-
34
-
-
0031022366
-
Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
-
Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314:253-257.
-
(1997)
BMJ
, vol.314
, pp. 253-257
-
-
Rai, R.1
Cohen, H.2
Dave, M.3
Regan, L.4
-
35
-
-
0029934389
-
Antiphospholipid antibody-associated recurrent pregnancy loss: Treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone
-
Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996; 174:1584-1589.
-
(1996)
Am J Obstet Gynecol
, vol.174
, pp. 1584-1589
-
-
Kutteh, W.H.1
-
36
-
-
0029970670
-
A clinical trial for the treatment of antiphospholipid antibody-associated recurrent pregnancy loss with lower dose heparin and aspirin
-
Kutteh WH, Ermel LD. A clinical trial for the treatment of antiphospholipid antibody-associated recurrent pregnancy loss with lower dose heparin and aspirin. Am J Reprod Immunol 1996; 35:402-407.
-
(1996)
Am J Reprod Immunol
, vol.35
, pp. 402-407
-
-
Kutteh, W.H.1
Ermel, L.D.2
-
37
-
-
2342633147
-
Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder
-
Gris J, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103:3695-3699. This prospective trial was the first study in which previous pregnancy loss was not used as a comparison. Low-molecular-weight heparin was associated with a higher rate of live births in all women and also in each group with FVL, prothrombin or protein S deficiency.
-
(2004)
Blood
, vol.103
, pp. 3695-3699
-
-
Gris, J.1
Mercier, E.2
Quere, I.3
-
38
-
-
0033859751
-
Laboratory testing for heritable thrombophilia: Impact on clinical management of thrombotic disease [miscellaneous]
-
Greaves M, Baglin T. Laboratory testing for heritable thrombophilia: impact on clinical management of thrombotic disease [miscellaneous]. Br J Haematol 2000; 109:699-703.
-
(2000)
Br J Haematol
, vol.109
, pp. 699-703
-
-
Greaves, M.1
Baglin, T.2
-
39
-
-
0034628535
-
Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium
-
Gerhardt A, Scharf RE, Beckmann MW, et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med 2000; 342:374-380.
-
(2000)
N Engl J Med
, vol.342
, pp. 374-380
-
-
Gerhardt, A.1
Scharf, R.E.2
Beckmann, M.W.3
-
40
-
-
0036606079
-
Cost-effectiveness of screening for the factor V Leiden mutation in pregnant women
-
Clark P, Twaddle S, Walker ID, et al. Cost-effectiveness of screening for the factor V Leiden mutation in pregnant women. Lancet 2002; 359:1919-1920.
-
(2002)
Lancet
, vol.359
, pp. 1919-1920
-
-
Clark, P.1
Twaddle, S.2
Walker, I.D.3
|