Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods

Journal of Photochemistry and Photobiology B: Biology

Volumn 79, Issue 1, 2005, Pages 25-34

  Neumann, Norbert J ^a   Blotz, Andrea ^a,b   Wasinska Kempka, Grazyna ^b   Rosenbruch, Martin ^b   Lehmann, Percy ^a   Ahr, Hans Jürgen ^b   Vohr, Hans Werner ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

Acute phototoxicity assay; In vitro phototoxicity assay; Integrated model for the differentiation of skin reactions; Photo hen's egg test; Photoallergic; Photosensitizer; Phototoxic; Quinolone

Indexed keywords

8 CHLORO 1 CYCLOPROPYL 7 (2,8 DIAZABICYCLO[4.3.0]NON 8 YL) 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; ACRIDINE; CHLORPROMAZINE; CIPROFLOXACIN; ENOXACIN; HEMATOPORPHYRIN; LOMEFLOXACIN; METHOXSALEN; MOXIFLOXACIN; OFLOXACIN; OLAQUINDOX; PHOTOSENSITIZING AGENT; PROMETHAZINE; PROTOPORPHYRIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN; TOXIC SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG SCREENING; FEMALE; FIBROBLAST 3T3 TEST; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; INTEGRATED MODEL FOR THE DIFFERENTIATION OF SKIN REACTION; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; PHOTO HEN EGG TEST; PHOTOALLERGY; PHOTOTOXICITY; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ANIMALS; CELL LINE; CHICK EMBRYO; DERMATITIS, PHOTOALLERGIC; DERMATITIS, PHOTOTOXIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; GUINEA PIGS; MICE; MICE, INBRED BALB C; PHARMACEUTICAL PREPARATIONS; ULTRAVIOLET RAYS;

EID: 15844424324     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2004.11.014     Document Type: Article

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