Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation

Journal of Cell Biology

Volumn 132, Issue 5, 1996, Pages 937-944

  Ferns, Michael ^a,b,c   Deiner, Michael ^a   Hall, Zach ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c MONTREAL GENERAL HOSPITAL   (Canada)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; CHOLINERGIC RECEPTOR; STAUROSPORINE;

ARTICLE; BETA CHAIN; MAMMAL CELL; NERVE ENDING; NEUROMUSCULAR SYNAPSE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA SPLICING;

AGRIN; ALKALOIDS; ANIMALS; BENZOQUINONES; CELLS, CULTURED; ENZYME INHIBITORS; LACTAMS, MACROCYCLIC; MICE; MUSCLES; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; QUINONES; RECEPTOR AGGREGATION; RECEPTORS, CHOLINERGIC; SIGNAL TRANSDUCTION; STAUROSPORINE;

EID: 0029928633     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.132.5.937     Document Type: Article

References (35)

1. Adams, M.E., M.H. Butler, T.M. Dwyer, M.F. Peters, A.A. Murnane, and S.C. Froehner. 1993. Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 11: 531-540.
2. Bowe, M.A , K.A. Deyst, J.D. Leszyk, and J.R. Fallon. 1994. Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans. Neuron. 12:1173-1180.
3. Campanelli, J.T., M.J. Ferns, W. Hoch, F. Rupp, M. von Zastrow, Z. Hall, and R.H. Scheller. 1993. Agrin: a synaptic basal lamina protein that regulated development of the neuromuscular junction. Cold Spring Harbor Symp. Quant. Biol. LVII:461-472.
4. Campanelli, J.T., S.L. Roberds, K.P. Campbell, and R.H. Scheller. 1994 A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell 77:663-674.
5. Fallon, J.R., and Z.W. Hall 1994. Building synapses: agrin and dystroglycan stick together. Trends Neurosci. 17:469-473.
6. Ferns, M.J., and Z.W. Hall. 1992. How many agrins does it take to make a synapse? Cell. 70:1-3.
7. Ferns, M.J., J.T. Campanelli, W. Hoch, R.H. Scheller, and Z. Hall. 1993. The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron. 11:491-502.
8. Froehner, S.C. 1991. The submembrane machinery for nicotinic acetylcholine receptor clustering. J. Cell Biol. 114:1-7.
9. Froehner, S.C., C.W. Luetje, P.B. Scotland, and J. Patrick. 1990. The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes. Neuron. 5:403-410.
10. Gee, S.H., F. Montanaro, M.H. Lindenbaum, and S. Carbonetto. 1994. Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor. Cell. 77:675-686.
11. Gordon, H., and Z.W. Hall. 1989. Glycosaminoglycan variants in the C2 muscle cell line. Dev. Biol. 135:1-11.
12. Gordon, H., M. Lupa, D. Bowen, and Z. Hall. 1993. A muscle cell variant defective in glycosaminoglycan biosynthesis forms nerve-induced, but not spontaneous clusters of the acetylcholine receptor and the 43kD protein. J. Neurosci 13:586-595.
13. Gumbiner, B.M. 1993. Proteins associated with the cytoplasmic surface of adhesion molecules. Neuron 11:551-564.
14. Hall, Z.W., and J.R. Sanes. 1993. Synaptic structure and development: the neuromuscular junction. Neuron 10(Suppl.) 99-121.
15. Hoch, W., M. Ferns, J.T. Campanelli, Z.W. Hall, and R.H. Scheller. 1993. Developmental regulation of highly active alternatively spliced forms of agrin. Neuron. 11:479-490.
16. Huganir, R.L., and K. Miles. 1989 Protein phosphorylation of nicotinic acetylcholine receptors. Crit. Rev. Biochem. Mol. Biol. 24:183-215.
17. Ibraghimov-Beskrovnaya, O., J.M. Ervasti, C.J. Leveille, C.A. Slaughter, S.W. Sernett, and K.P Campbell. 1992. Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature (Lond.). 355.696-702.
18. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell. 76:253-262.
19. McMahan, U.J. 1990. The agrin hypothesis. Cold Spring Harbor Symp. Quant Biol LV:407-418.
20. Phillips, W.P., C. Kopta, P. Blount, P.D. Gardner, J.H. Steinbach, and J.P. Merlie. 1991. ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kilodalton protein. Science (Wash. DC). 251:568-570.
21. Qu, Z., and R.L. Huganir. 1994. Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor. J. Neurosci. 14:6834-6841.
22. Qu, Z., E Moritz, and R.L. Huganir. 1990. Regulation of tyrosine phosphoryiation of the nicotinic acetylcholine receptor at the rat neuromuscular junction. Neuron. 2:367-378.
23. Ruegg, M.A., K.W.K. Tsim, S.E. Horton, S. Kroger, G. Escher, E.M. Gensch, and U.J. McMahan. 1992. The agrin gene codes for a family of basal lamina proteins that differ in function and distribution. Neuron. 8:691-699
24. Schlessinger, J , and A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron. 9:383-391.
25. Sealock, R., and S.C. Froehner. 1994. Dystrophin-associated proteins and synapse formation: is a-dystroglycan the agrin receptor? Cell. 77 617-619.
26. Sugiyama, J., D.C. Bowen, and Z.W. Hall. 1994. Dystroglycan binds nerve and muscle agrin. Neuron. 13:1-20.
27. Tsim, K W.K , M.A. Ruegg, G. Escher, S. Kroger, and U.J. McMahan. 1992. cDNA that encodes active agrin. Neuron. 8:677-689.
28. Wagner, K., K. Edson, L. Heginbotham, M. Post, R.L. Huganir, and A.J. Czernik. 1991. Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor. J. Biol Chem. 266:23784-23789.
29. Wagner, K.R., J.B. Cohen, and R.L. Huganir. 1993. The 87K postsynaptic membrane protein from Torpedo is a protein-tyrosine kinase substrate homologous to dystrophin. Neuron 10.511-522
30. Wallace, B.G. 1989. Agrin-induced specializations contain cytoplasmic, membrane, and extracellular matrix-associated components of the postsynaptic apparatus J. Neurosci. 9:1294-1302.
31. Wallace, B.G 1994. Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation. J. Cell Biol. 125 661-668.
32. Wallace, B.G. 1995. Regulation of the interaction of nicotinic acetylcholine receptors with the cytoskeleton by agrin-activated protein tyrosine kinase J Cell Biol. 128:1121-1129.
33. Wallace, B G., Z. Qu, and R.L. Huganir. 1991. Agrin induces phosphorylation of the nicotinic acetylcholine receptor. Neuron. 6:869-878.
34. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
35. Yu, X.-M., and Z.W. Hall. 1994 The role of the cytoplasmic domains of individual subunits of the acetylcholine receptor in 43 kDa protein-induced clustering in COS cells. J. Neurosci. 14:785-795.