Furin directly cleaves proMMP-2 in the trans-golgi network resulting in a nonfunctioning proteinase

Journal of Biological Chemistry

Volumn 280, Issue 12, 2005, Pages 10974-10980

  Cao, Jian ^a,d   Rehemtulla, Alnawaz ^b   Pavlaki, Maria ^a   Kozarekar, Pallavi ^a   Chiarelli, Christian ^c  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; DNA; MATRIX ALGEBRA; MEMBRANES; TISSUE; TUMORS;

FURIN; SCISSILE BOND; TRANS-GOLGI NETWORK; TUMORIGENESIS;

PROTEINS;

AMINO ACID; COMPLEMENTARY DNA; FURIN; GELATINASE A; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; PROTEINASE; STROMELYSIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CELL LYSATE; CELL STRAIN COS1; CHEMICAL BOND; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; TRANS GOLGI NETWORK;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; ENZYME PRECURSORS; FURIN; GELATINASES; HUMANS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; TRANS-GOLGI NETWORK;

ANIMALIA;

EID: 15744404638     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412370200     Document Type: Article

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