Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation

Immunology Letters

Volumn 98, Issue 1, 2005, Pages 63-72

  Noh, Kahwa ^a   Lim, Hyunja ^a   Moon, Sung Kyu ^a   Kang, Jae Seung ^a   Lee, Wang Jae ^a   Lee, Dongsup ^a   Hwang, Young Il ^a  

^a Seoul National University   (South Korea)

Author keywords

Delayed type hypersensitivity; Isotype; Mega dose; T cell activation; Th1 polarization; Vitamin C

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ASCORBIC ACID; GAMMA INTERFERON; HEMAGGLUTININ; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 2; INTERLEUKIN 4; THYMIDINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; IMMUNIZATION; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 15744381035     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.10.012     Document Type: Article

References (50)

1. J.V. Hidgon, and B. Frei Vitamin C an introduction L. Packer M.G. Traber K. Kraemer B. Frei The antioxidant Vitamins C and E 2002 AOCS Press Illinois 1 16 Chapter 1
2. K.A. Naidu Vitamin C in human health and disease is still a mystery? An overview Nutr J 2 2003 7
3. R. Anderson, and O.C. Dittrich Effects of ascorbate on leucocytes: Part IV, Increased neutrophil function and clinical improvement after oral ascorbate in 2 patients with chronic granulomatous disease S Afr Med J 56 1979 476 480
4. R. Anderson, R. Oosthuizen, R. Maritz, A. Theron, and A.J. Van Rensburg The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers Am J Clin Nutr 33 1980 71 76
5. M. De La Fuente, M.D. Ferrandez, M.S. Burgos, A. Soler, A. Prieto, and J. Miquel Immune function in aged women is improved by ingestion of Vitamins C and E Can J Physiol Pharmacol 76 1988 373 380
6. M. Del Rio, G. Ruedas, S. Medina, V.M. Victor, and M. De La Fuente Improvement by several antioxidants of macrophage function in vitro Life Sci 63 1998 871 881
7. B. Kennes, I. Dumont, D. Brohee, C. Hubert, and P. Neve Effect of Vitamin C supplements on cell-mediated immunity in old people Gerontology 29 1983 305 310
8. B.V. Siegel, and J.I. Morton Vitamin C and the immune response Experientia 33 1977 393 395
9. J.D. Campbell, M. Cole, B. Bunditrutavorn, and A.T. Vella Ascorbic acid is a potent inhibitor of various forms of T cell apoptosis Cell Immunol 194 1999 1 5
10. I. Perez-Cruz, J.M. Carcamo, and D.W. Golde Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells Blood 102 2003 336 343
11. G. Heuser, and A. Vojdani Enhancement of natural killer cell activity and T and B cell function by buffered Vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C Immunopharmacol Immunotoxicol 19 1997 291 312
12. A. Vojdani, M. Bazargan, E. Vojdani, and J. Wright New evidence for antioxidant properties of Vitamin C Cancer Detect Prev 24 2000 508 523
13. A. Nandi, C.K. Mukhopadhyay, M.K. Ghosh, D.J. Chattopadhyay, and I.B. Chatterjee Evolutionary significance of Vitamin C biosynthesis in terrestrial vertebrates Free Radic Biol Med 22 1997 1047 1054
14. M. Levine, C. Conry-Cantilena, Y. Wang, R.W. Welch, P.W. Washko, K.R. Dhariwal, J.B. Park, A. Lazarev, J.F. Graumlich, J. King, and L.R. Cantilena Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance Proc Natl Acad Sci USA 93 1996 3704 3709
15. C.M. Loria, M.J. Klag, L.E. Caulfield, and P.K. Whelton Vitamin C status and mortality in US adults Am J Clin Nutr 72 2000 139 145
16. K.T. Khaw, S. Bingham, A. Welch, R. Luben, N. Wareham, S. Oakes, and N. Day Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study European prospective investigation into cancer and nutrition Lancet 357 2001 657 663
17. K.A. Head Ascorbic acid in the prevention and treatment of cancer Altern Med Rev 3 1998 174 186
18. B. Frei On the role of Vitamin C and other antioxidants in atherogenesis and vascular dysfunction Proc Soc Exp Biol Med 222 1999 196 204
19. S.A. Bsoul, and G.T. Terezhalmy Vitamin C in health and disease J Contemp Dent Pract 5 2004 1 14
20. X. Wang, R. Willen, and T. Wadstrom Astaxanthin-rich algal meal and Vitamin C inhibit Helicobacter pylori infection in BALB/cA mice Antimicrob Agents Chemother 44 2000 2452 2457
21. W.D. Du, Z.R. Yuan, J. Sun, J.X. Tang, A.Q. Cheng, D.M. Shen, C.J. Huang, X.H. Song, X.F. Yu, and S.B. Zheng Therapeutic efficacy of high-dose Vitamin C on acute pancreatitis and its potential mechanisms World J Gastroenterol 9 2003 2565 2569
22. C.S. Johnston Biomarkers for establishing a tolerable upper intake level for Vitamin C Nutr Rev 57 1999 71 77
23. K.H. Noh, H.G. Kim, Y.A. Shin, H.J. Lim, S.K. Moon, Y.T. Lee, W.J. Lee, D.S. Lee, and Y.I. Hwang The effects of high-dose Vitamin C administration on the cell-mediated immune response in mice Immune Network 3 2003 211 218
24. F.S. Dhabhar, and B.S. McEwen Stress-induced enhancement of antigen-specific cell-mediated immunity J Immunol 156 1996 2608 2615
25. M. Krasteva, J. Kehren, F. Horand, H. Akiba, G. Choquet, M.T. Ducluzeau, R. Tedone, J.L. Garrigue, D. Kaiserlian, and J.F. Nicolas Dual role of dendritic cells in the induction and down-regulation of antigen-specific cutaneous inflammation J Immunol 160 1998 1181 1190
26. K. Kobayashi, K. Kaneda, and T. Kasama Immunopathogenesis of delayed-type hypersensitivity Microsc Res Tech 53 2001 241 245
27. K.M. Murphy, and S.L. Reiner The lineage decisions of helper T cells Nat Rev Immunol 2 2002 933 944
28. K.L. Buchanan, and J.W. Murphy Kinetics of cellular infiltration and cytokine production during the efferent phase of a delayed-type hypersensitivity reaction Immunology 90 1997 189 197
29. J. Marcinkiewicz Cell-mediated immunity: role of IL-3 and IL-6 in the regulation of contact sensitivity reaction Folia Histochem Cytobiol 28 1990 107 119
30. D.P. Steenvoorden, and G. Beijersbergen van Henegouwen Protection against UV-induced systemic immunosuppression in mice by a single topical application of the antioxidant Vitamins C and E Int J Radiat Biol 75 1999 747 755
31. W.C. Quevedo Jr., T.J. Holstein, J. Dyckman, C.J. McDonald, and E.L. Isaacson Inhibition of UVR-induced tanning and immunosuppression by topical applications of Vitamins C and E to the skin of hairless (hr/hr) mice Pigment Cell Res 13 2000 89 98
32. O. Cetinkale, O. Senel, and R. Bulan The effect of antioxidant therapy on cell-mediated immunity following burn injury in an animal model Burns 25 1999 113 118
33. E.M. Bulger, I. Garcia, and R.V. Maier Intracellular antioxidant activity is necessary to modulate the macrophage response to endotoxin Shock 18 2002 58 63
34. B.M. Winklhofer-Roob, H. Ellemunter, M. Fruhwirth, S.E. Schlegel-Haueter, G. Khoschsorur, M.A. van't Hof, and D.H. Shmerling Plasma Vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation Am J Clin Nutr 65 1997 1858 1866
35. A.G. Bowie, and L.A. O'Neill Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase J Immunol 165 2000 7180 7188
36. J.W. Horton, D.J. White, D.L. Maass, D.P. Hybki, S. Haudek, and B. Giroir Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion J Traumatol 50 2001 397 408
37. J.M. Carcamo, A. Pedraza, O. Borquez-Ojeda, and D.W. Golde Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting Ikappa B alpha phosphorylation Biochemistry 41 2002 12995 13002
38. T. Renno, A. Attinger, S. Locatelli, T. Bakker, S. Vacheron, and H.R. MacDonald Cutting edge: apoptosis of superantigen-activated T cells occurs preferentially after a discrete number of cell divisions in vivo J Immunol 162 1999 6312 6315
39. F. Vasseur, A. Le Campion, J.H. Pavlovitch, and C. Penit Distribution of cycling T lymphocytes in blood and lymphoid organs during immune responses J Immunol 162 1999 5164 5172
40. N.D. Penn, L. Purkins, J. Kelleher, R.V. Heatley, B.H. Mascie-Taylor, and P.W. Belfield The effect of dietary supplementation with Vitamins A C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial Age Ageing 20 1991 169 174
41. K.J. Malmberg, R. Lenkei, M. Petersson, T. Ohlum, F. Ichihara, B. Glimelius, J.E. Frodin, G. Masucci, and R. Kiessling A short-term dietary supplementation of high doses of Vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer Clin Cancer Res 8 2002 1772 1778
42. A.K. Abbas, K.M. Murphy, and A. Sher Functional diversity of helper T lymphocytes Nature 383 1996 787 793
43. T.R. Mosmann, and S. Sad The expanding universe of T cell subsets: Th1 Th2 and more Immunol Today 17 1996 138 146
44. K. Takatsu Cytokines involved in B-cell differentiation and their sites of action Proc Soc Exp Biol Med 215 1997 121 133
45. W. Prinz, R. Bortz, B. Bregin, and M. Hersch The effect of ascorbic acid supplementation on some parameters of the human immunological defence system Int J Vitam Nutr Res 47 1977 248 257
46. G.A. Feigen, B.H. Smith, C.E. Dix, C.J. Flynn, N.S. Peterson, L.T. Rosenberg, S. Pavlovic, and B. Leibovitz Enhancement of antibody production and protection against systemic anaphylaxis by large doses of Vitamin C Res Commun Chem Pathol Pharmacol 38 1982 313 333
47. R. Anderson, R. Oosthuizen, R. Maritz, A. Theron, and A.J. Van Rensburg The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers Am J Clin Nutr 33 1980 71 76
48. W. Prinz, J. Bloch, G. Gilich, and G. Mitchell A systematic study of the effect of Vitamin C supplementation on the humoral immune response in ascorbate-dependent mammals I. The antibody response to sheep red blood cells (a T-dependent antigen) in guinea pigs Int J Vitam Nutr Res 50 1980 294 357
49. R. Anderson, I. Hay, H. van Wyk, R. Oosthuizen, and A. Theron The effect of ascorbate on cellular humoral immunity in asthmatic children S Afr Med J 58 1980 974 977
50. K.Z. Long, and J.I. Santos Vitamins and the regulation of the immune response Pediatr Infect Dis J 18 1999 283 290