Research development on the bone affinity compound related to bone-targeted drugs

Yaoxue Xuebao

Volumn 38, Issue 1, 2003, Pages 75-78

  Zheng, Hu ^a   Huang, Wen Cai ^a   Lou, Rong Liang ^a,b   Weng, Ling Ling ^a  

^a SICHUAN UNIVERSITY   (China)

^b Rensselaer Polytechnic Institute   (United States)

Author keywords

Bone affinity; Bone targeted drugs; Carrier; Hydroxyapatite

Indexed keywords

EID: 15744377497     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Pierce WM, Leonard WC. Bone targeted inhibitors of carbonic anhydrase [P]. Eur Patent: 201057, 1986-11-12.
2. Perrin RA. Binding of tetracycline to bone [J]. Nature, 1965,208(11):787-788.
3. Misra DD. Adsorption and orientation of tetracycline on hydroxyapatite [J]. Calcif Tissue Int, 1991,48(5):362-367.
4. Bando N, Kawai T, Hamazaki T, et al. Preparation of tetracycline derivatives as collagenase inhibitors [P]. Jpn Pat: 04178359, 1992-06-25.
5. Hanne B, David R. Conjugated for targeted delivery of bone growth factors [P]. Eur Pat: 512844, 1992-11-11.
6. a. Zheng H, Weng LL. The compound that can be used to prepare bone-targeted drugs bearing estrogen structure [P]. China Pat: 94111687.5, 1993-11-09.
7. b. Zheng H, Weng LL. Bone resorption inhibition/osteogenesis promotion pharmaceutical composition [P]. US Pat: 5698542, 1997-12-16.
8. Orme MW, Labroo VM. Synthesis of α-estradiol-3-benzoate-17- (succinyl-12α-tetracycline): a potential bone-seeking estrogen [J]. Bioorg Med Chem Lett, 1994,4(11):1375-1380.
9. Thompson WJ, Thompson DD, Anderson PS, et al. Polymalonic acids as bone affinity agents [P]. Eur Pat: 341961, 1989-11-15.
10. Fleisch H. Bisphosphonates: Mechanisms of action [J]. Endocr Rev, 1998,19(1):80-100.
11. Rogers MJ, Frith JC, Luckman SP, et al. Molecular mechanisms of action of bisphosphonates [J]. Bone, 1999, 24(5):73-79(suppl).
12. Fujisaki J, Tilunage Y, Kagayama A, et al. Preparation of diphosphonic acid derivatives-modified pharmaceuticals with improved bio-availabilities in bone [P]. Jpn Pat: 02268190, 1990-11-01.
13. Takashi K, Hideyuki H, Akira S, et al. New bone-seeking estrogen derivatives [P]. Eur Pat: 0827951, 1998-3-11.
14. Uluday H, Kousinioris N, Gao TJ, et al. Bisphosphonate conjugation to proteins as a means to impart bone affinity [J]. Biotechnol Prog, 2000,16(2):258-267.
15. Laurent G, Han YX, Rejean R, et al. Prostaglandin-bisphosphonate conjugates: their preparation and their use in treating or preventing bone disease [P]. World Pat: 0031084, 2000-06-02.
16. Dixon HBF, Mikhallov S, Nelly P, et al. Biphosphonate conjugates and methods of making and using the same [P]. US Pat: 6214812, 2001-04-10.
17. Willon TM, Paul SC, Anthony DB, et al. Bone targeted drugs 1. Identification of heterocycles with hydroxyapatite affinity [J]. Bioorg Med Chem Lett, 1996,6(9):1043-1046.
18. Kasugai S, Fujisawa R, Waki Y, et al. Selctive drug delivery system to bone: small peptide (Asp) 6 conjugation [J]. J Bone Miner Res, 2000,15(5):936-943.