Rapid differential diagnosis of Graves' disease and painless thyroiditis using total T3/T4 ratio, TSH, and total alkaline phosphatase activity

Endocrine Journal

Volumn 52, Issue 1, 2005, Pages 29-36

  Yanagisawa, Tetsuo ^a   Sato, Kanji ^a   Kato, Yoshiyuki ^a   Shimizu, Satoru ^a   Takano, Kazue ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Alkaline phosphatase; Graves' disease; Painless thyroiditis; Subacute thyroiditis

Indexed keywords

ALKALINE PHOSPHATASE; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; GRAVES DISEASE; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PAINLESS THYROIDITIS; THYROIDITIS; THYROTOXICOSIS; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADULT; ALKALINE PHOSPHATASE; FEMALE; GRAVES DISEASE; HUMANS; LIKELIHOOD FUNCTIONS; MALE; MIDDLE AGED; PAIN; THYROIDITIS; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 15744376212     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.52.29     Document Type: Article

References (33)

1. Cooper DS (2001) Treatment of thyrotoxicosis. In: Braverman LR, Utiger RD (eds) Werner & Ingbar's Thyroid. 8th ed, J. B. Lippincott Co., Philadelphia, 691-718.
2. Amino N, Yabu Y, Miki T, Morimoto S, Kumahara Y, Mori H, Iwatani Y, Nishi K, Nakatani K, Miyai K (1981) Serum ratio of triiodothyronine to thyroxine, and thyroxine-binding globulin and calcitonin concentrations in Graves' disease and destruction-induced thyrotoxicosis. J Clin Endocrinol Metab 53: 113-116.
3. Izumi Y, Hidaka Y, Tada H, Takano T, Kashiwai T, Tatsumi KI, Ichihara K, Amino N (2002) Simple and practical parameters for differentiation between destruction-induced thyrotoxicosis and Graves' thyrotoxicosis. Clin Endocrinol 57: 51-58.
4. Kasagi K, Kousaka T, Misaki T, Iwata M, Alam MS, Konishi J (1999) Comparison of serum thyrotrophin concentrations determined by a third generation assay in patients with various types of overt and subclinical thyrotoxicosis. Clin Endocrinol 50: 185-189.
5. Sayama N, Yoshida K, Mori K, Fukazawa H, Hori H, Nakazato N, Tani J, Nakagawa Y, Ito S (1998) Measurement of red blood cell zinc concentration with Zn-test kit: discrimination between hyperthyroid Graves' disease and transient thyrotoxicosis. Endocr J 45: 767-772.
6. Schott M, Feldkamp J, Bathan C, Fritzen R, Scherbaum WA, Seissler J (2000) Detecting TSH-receptor antibodies with the recombinant TBII assay: technical and clinical evaluation. Horm Metab Res 32: 429-435.
7. Costagliola S, Morgenthaler NG, Hoermann R, Badenhoop K, Struck J, Freitag D, Poertl S, Weglohner W, Hollidt JM, Quadbeck B, Dumont JE, Schumm-Draeger PM, Bergmann A, Mann K, Vassart G, Usadel KH (1999) Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease. J Clin Endocrinol Metab 84: 90-97.
8. Morita T, Tamai H, Oshima A, Mukuta T, Fukata S, Kuma K, Kumagai LF, Nagataki S (1990) The occurrence of thyrotropin binding-inhibiting immunoglobulins and thyroid-stimulating antibodies in patients with silent thyroiditis. J Clin Endocrinol Metab 71: 1051-1055.
9. Yoshimura-Noh J, Ito K, Uchimura H, Onaya T, Takasu N, Kasagi K, Yamashita K, Ochi Y, Yokoyama N, Nagataki S (1994) Clinical evaluation of thyroid stimulating antibody (TSAb) by Yamasa TSAb kit. Horumon to Rinsho 42: 167-172 (in Japanese).
10. Sato K, Yamazaki K, Yamada E, Kanaji Y, Miura M, Obara T (1999) Immunoglobulin G of untreated Graves' patients with or without TSH receptor antibody (determined by porcine thyrocytes) universally elicit potent thyroid hormone-releasing activity in cultured human thyroid follicles. Thyroid 9: 979-988.
11. Sato K, Han DC, Fujii Y, Tsushima T, Shizume K (1987) Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3′-triiodo-L-thyronine nuclear receptors. Endocrinology 120: 1873-1881.
12. Abu SO, Bord S, Horner A, Chatterjee VK, Compaton JE (1997) The expression of thyroid hormone receptors in human bone. Bone 21: 137-142.
13. Britto JM, Fenton AJ, Holloway WR, Nicholson GC (1994) Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption. Endocrinology 134: 169-176.
14. 3 in osteoclast formation. Biochem Biophys Res Commun 291: 987-994.
15. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345-357.
16. Eriksen EF, Mosekilde L, Melsen F (1985) Trabecular bone remodeling and bone balance in hyperthyroidism. Bone 6: 421-428.
17. Hasling C, Eriksen EF, Charles P, Mosekilde L (1987) Exogenous triiodothyronine activates bone remodeling. Bone 8: 65-69.
18. Smith SR, Lovejoy JC, Rood J, Most M, Wickersham PJ, Volaufova J, Ryan D, Tulley R, Bray GA (2003) The effects of triiodothyronine on bone metabolism in healthy ambulatory men. Thyroid 13: 357-364.
19. Cooper DS, Kaplan MM, Ridgway EC, Maloof F, Daniels GH (1979) Alkaline phosphatase isoenzyme patterns in hyperthyroidism. Ann Intern Med 90: 164-168.
20. Siddiqi A, Burrin JM, Noonan K, James I, Wood DF, Price CP, Monson JP (1997) A longitudinal study of markers of bone turnover in Graves' disease and their value in predicting bone mineral density. J Clin Endocrinol Metab 82: 753-759.
21. Jaeschke R, Guyatt G, Lijmer J (2002) Diagnosis tests. In Guyatt G, Rennie D (eds) User's Guides to the Medical Literature, ch.1C2, Chicago: American Medical Association. 187-217.
22. Ito M, Takamatsu J, Yoshida S, Murakami Y, Sakane S, Kuma K, Ohsawa N (1997) Incomplete thyrotroph suppression determined by third generation thyrotropin assay in subacute thyroiditis compared to silent thyroiditis or hyperthyroid Graves' disease. J Clin Endocrinol Metab 82: 616-619.
23. Salvatore D, Tu H, Harney JW, Larsen PR (1996) Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 15: 962-968.
24. Murakami M, Araki O, Hosoi Y, Kamiya Y, Morimura T, Ogiwara T, Mizuma H, Mori M (2001) Expression and regulation of type II iodothyronine deiodinase in human thyroid gland. Endocrinology 142: 2961-2967.
25. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23: 38-89.
26. Hofbauer LC, Heufelder AE (2000) The role of receptor activator of nuclear factor-kB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone disease. J Clin Endocrinol Metab 85: 2355-2363.
27. Mose DW (1997) Physicochemical and pathophysiological factors in the release of membrane-bound alkaline phosphatase from cells. Clin Chim Acta 3: 133-140.
28. Henthorn PS, Paula SH (1996) Alkaline phosphatase. In Bilezikian JP, Raisz LG, Rodan GA (eds), Principles of Bone Biology, first ed, San Diego, CA, Academic Press, 197-206.
29. Banovac K, Koren E (2000) Triiodothyronine stimulates the release of membrane-bound alkaline phosphatase in osteoblastic cells. Calcif Tissue Int 67: 460-465.
30. Frevert EU, Biester A, Muller MJ, Schmidt-Gayk H, von zur Muhlen A, Brabant G (1994) Markers of bone metabolism during short-term administration of thyroxine in healthy volunteers. Eur J Endocrinol 131: 145-149.
31. Emerson CH, Farwell AP (2001) Sporadic silent thyroiditis, postpartum thyroiditis, and subacute thyroiditis. In: Braverman LE, Utiger RD (eds) Werner & Ingbar's the Thyroid, ed 8, Philadelphia, Lippincott, 578-589.
32. Kimura M, Amino N, Takeda K, Miyai K (1989) Subacute thyroiditis associated with systemic multi-organ disorders. Endocrinol Jpn 36: 859-864.
33. Potasman I, Bassan H, Rosenfeld T (1983) Alkaline phosphatase activity in subacute thyroiditis and hyperthyroidism. Isr J Med Sci 19: 571-574.