Protection of monkeys vaccinated with vpr- and/or nef-defective simian immunodeficiency virus strain mac/human immunodeficiency virus type 1 chimeric viruses: A potential candidate live-attenuated human AIDS vaccine

Journal of General Virology

Volumn 78, Issue 5, 1997, Pages 985-989

  Igarashi, Tatsuhiko ^a,b   Ami, Yasushi ^c   Yamamoto, Hiroshi ^d   Shibata, Riri ^a,f   Kuwata, Takeo ^a   Mukai, Ryozaburo ^c   Shinohara, Katsuaki ^e   Komatsu, Toshihiko ^e   Adachi, Akio ^a   Hayami, Masanori ^a  

^a KYOTO UNIVERSITY   (Japan)

^b The Japan Foundation   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF TOYAMA   (Japan)

^e NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE; NEUTRALIZING ANTIBODY; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENVELOPE GENE; HUMAN IMMUNODEFICIENCY VIRUS 1; KILLER CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; VACCINATION; VIRUS IMMUNITY; VIRUS RECOMBINANT;

EID: 15644374365     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-5-985     Document Type: Article

References (14)

1. Almond, N., Kent, K., Cranage, M., Rud, E., Clarke, B. & Stott, E. J. (1995). Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells. Lancet 345, 1342-1344.
2. Baba, T. W., Jeong, Y. S., Penninck, D., Bronson, R., Greene, M. F. & Ruprecht, R. M. (1995). Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1825.
3. Clements, J. E., Montelaro, R. C., Zink, M. C, Amedee, A. M., Miller, S., Trichel, A. M., Jagerski, B., Hauer, D., Martin, L. N., Bohm, R. P. & Murphy-Corb, M. (1995). Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus. Journal of Virology 69, 2737-2744.
4. Daniel, M. D., Kirchhoff, F., Czajak, S. C., Sehgal, P. K. & Desrosiers, R. C. (1992). Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258, 1938-1941.
5. Igarashi, T., Shibata, R., Hasebe, F., Ami, Y., Shinohara, K., Komatsu, T., Stahl-Hennig, C., Petry, H., Hunsmann, G., Kuwata, T., Jin, M., Adachi, A., Kurimura, T., Okada, M., Miura, T. & Hayami, M. (1994). Persistent infection with SIVmac chimeric virus having tat, rev, vpu, env and nef of HIV-1 in macaque monkeys. AIDS Research and Human Retroviruses 10, 1021-1029.
6. Igarashi, T., Kuwata, T., Takehisa, J., Ibuki, K., Shibata, R., Mukai, R., Komatsu, T., Adachi, A., Ido, E. & Hayami, M. (1996). Genomic and biological alteration of a human immunodeficiency virus type 1 (HIV-1)-simian immunodeficiency virus strain mac chimera, with HIV-1 Env, recovered from a long-term carrier monkey. Journal of General Virology 77, 1649-1658.
7. Kestler, H. W., Ringler, D. J., Mori, K., Panicali, D. L., Sehgal, P. K., Daniel, M. D. & Desrosiers, R. C. (1991). Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651-662.
8. Kuwata, T., Igarashi, T., Ido, E., Jin, M., Mizuno, A., Chen, J. & Hayami, M. (1995). Construction of human immunodeficiency virus 1/simian immunodeficiency virus strain mac chimeric viruses having vpr and/or nef of different parental origins and their in vitro and in vivo replicaton. Journal of General Virology 76, 2181-2191.
9. Lang, S. M., Weeger, M., Stahl-Hennig, C., Coulibaly, C., Hunsmann, G., Müller, J., Müller-Hermelink, H., Fuchs, D., Wachter, H., Daniel, M. M., Desrosiers, R. C. & Fleckenstein, B. (1993). Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. Journal of Virology 67, 902-912.
10. Norley, S., Beer, B., Binninger-Schinzel, D., Cosma, C. & Kurth, R. (1996). Protection from pathogenic SIVmac challenge following short-term infection with a nef-deficient attenuated virus. Virology 219, 195-205.
11. Shibata, R., Kawamura, M., Sakai, H., Hayami, M., Ishimoto, A. & Adachi, A. (1991). Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. Journal of Virology 65, 3514-3520.
12. Shibata, R., Sakai, H., Kawamura, M., Tokunaga, K. & Adachi, A. (1995). Early replication block of human immunodeficiency virus type I in monkey cells. Journal of General Virology 76, 2723-2730.
13. Wyand, M. S., Manson, K. H., Garcia-Moll, M., Montefiori, D. & Desrosiers, R. C. (1996). Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. Journal of Virology 70, 3724-3733.
14. Yamamoto, H., Miller, M. D., Tsubota, H., Watkins, D. I., Mazzara, G. P., Stallard, V., Panicali, D. L, Aldovini, A., Young, R. A. & Letvin, N. L. (1990). Studies of cloned simian immunodeficiency virus-specific T lymphocytes. Journal of Immunology 44, 3385-3391.