Relationship between Clostridium septicum alpha-toxin activity and binding to erythrocyte membranes

Journal of Veterinary Medical Science

Volumn 67, Issue 1, 2005, Pages 69-74

  Hang'ombe, Mudenda B ^a   Kohda, Tomoko ^a   Mukamoto, Masafumi ^a   Kozaki, Shunji ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Alpha toxin; Clostridium septicum; Erythrocyte; Glycoprotein; Hemolysis

Indexed keywords

ANIMALIA; BOVINAE; CLOSTRIDIUM SEPTICUM; EQUIDAE; MURINAE; ORYCTOLAGUS CUNICULUS; OVIS; SUS SCROFA;

BACTERIAL TOXIN; HEMOLYSIN; HEMOLYTIC TOXIN, CLOSTRIDIUM SEPTICUM; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE;

ANIMAL; ARTICLE; CATTLE; CHICKEN; CLOSTRIDIUM; DOG; DRUG EFFECT; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; HORSE; IN VITRO STUDY; METABOLISM; MOUSE; PROTEIN BINDING; RABBIT; RAT; SHEEP; SPECIES DIFFERENCE; SWINE;

ANIMALS; BACTERIAL TOXINS; CATTLE; CHICKENS; CLOSTRIDIUM; DOGS; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HEMOLYSIN PROTEINS; HORSES; MICE; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PROTEIN BINDING; RABBITS; RATS; SHEEP; SPECIES SPECIFICITY; SWINE;

EID: 15544380339     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.67.69     Document Type: Article

References (22)

1. Amimoto, K., Ohgitani, T., Sasaki, O., Oishi, E., Katayama, S., Isogai, M. and Ota, S. 2002. Protective effect of Clostridium septicum alpha-toxoid vaccine against challenge with spores in guinea pigs. J. Vet. Med. Sci. 64: 67-69.
2. Ballard, J., Bryant, A., Stevens, D. and Tweten, R.K. 1992. Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum. Infect. Immun. 60: 784-790.
3. Ballard, J., Sokolov, Y., Yuan, W.L., Kagan, B.L. and Tweten, R.K. 1993. Activation and mechanism of Clostridium septicum alpha-toxin. Mol. Microbiol. 10: 627-634.
4. Ballard, J., Crabtree, J., Roe, B.A. and Tweten, R.K. 1995. The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect. Immun. 63: 340-344.
5. Blood, D.C. and Radostits, O.M. 1989. A Text Book of Veterinary Medicine, 7th ed., Bailliere Tindall, London.
6. Diep, B.Z., Nelson, L.K., Lawrence, S.T., Sellman, R.B., Tweten, K.R. and Buckley, T.J. 1999. Expression and properties of an aerolysin-Clostridium septicum alpha-toxin hybrid protein. Mol. Microbiol. 31: 785-794.
7. Gordon, V.M., Benz, R., Fujii, K., Leppla, S.H. and Tweten, R.K. 1997. Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect. Immun. 65: 4130-4134.
8. Gordon, V.M., Nelson, K.L., Buckley, J.T., Stevens, V.L., Tweten, R.K., Elwood, P.C. and Leppla, S.H. 1999. Clostridium septicum alpha-toxin uses glycosylphosphatidylinositol-anchored protein receptors. J. Biol. Chem. 274: 27274-27280.
9. Harlow, E. and Lane, D. 1988. Storing and purifying antibodies. pp. 283-318. In: Antibodies a laboratory manual. Cold Spring Harbor Laboratory Press, New York.
10. Hong, Y., Ohishi, K., Inoue, N., Kang, J.Y., Shime, H., Horiguchi, Y., van der Goot, F.G., Sugimoto, N. and Kinoshita, T. 2002. Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin. EMBO J. 21: 5047-5056.
11. Howard, S.P. and Buckley, J.T. 1982. Membrane glycoprotein receptor and hole-forming properties of a cytolytic protein toxin. Biochemistry 21: 1662-1667.
12. Kozaki, S., Kato, K., Asao, T., Kamata, Y. and Sakaguchi, G. 1987. Activities of Aeromonas hydrophila hemolysins and their interaction with erythrocyte membranes. Infect. Immun. 55: 1594-1599.
13. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227: 680-685.
14. McConville, M.J. and Ferguson, M.A.J. 1993. The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem. J. 294: 305-324.
15. Sellman, B.R., Kagan, B.L. and Tweten, R.K. 1997. Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha-toxin. Mol. Microbiol. 23: 551-558.
16. Smith, D.S.L. 1975. Clostridium septicum. pp. 245-255. In: The pathogenic anaerobic bacteria. Charles C. Thomas, Springfield, III.
17. Stevens, V.L. 1995. Biosynthesis of glycosylphosphatidylinositol membrane anchors. Biochem. J. 310: 361-370.
18. Thomas, J.R., Dwek, R.A. and Rademacher, T.W. 1990. Structure, biosynthesis and function of glycosylphosphatidylinositols. Biochemistry 29: 5413-5422.
19. Tweten, R.K. and Sellman, R.B. 1999. Clostridium septicum pore-forming and lethal alpha-toxin. pp. 435-442. In: The Comprehensive Sourcebook of Bacterial Protein Toxins. (Alouf, J.E. and Freer, J.H. eds.), Academic press, London, UK.
20. Tweten, R.K. 2001. Clostridium perfringens beta-toxin and Clostridium septicum alpha-toxin: their mechanisms and possible role in pathogenesis. Vet. Microbiol. 82: 1-9.
21. Wichroski, M.J., Melton, J.A., Donahue, C.G., Tweten, R.K. and Ward, G.E. 2002. Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of Glycosylphosphatidylinositol-anchored surface proteins. Infect. Immun. 70: 4353-4361.
22. Wilson, L.M. and Macfarlane, G.T. 1996. Cytotoxicity, adhesion and invasion of Clostridium septicum in cultured human epithelial cells (CACO-2, HEp-2): Pathological significance of swarm cell differentiation. Anaerobe 2: 71-79.