Synthesis and Evaluation of a Novel Synthetic Phosphocholine Lipid-AZT Conjugate that Double-Targets Wild-Type and Drug Resistant Variants of HIV

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 1-2, 2004, Pages 385-399

  Kucera, Louis S ^a   Morris Natschke, Susan L ^b   Ishaq, Khalid S ^b   Hes, Jan ^c   Iyer, Nathan ^a   Furman, Phillip A ^c   Fleming, Ronald A ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Kucera Pharmaceutical Company   (United States)

Author keywords

Antiretrovirus drug conjugates; Drug resistant HIV; Phosphocholine lipid analog conjugate

Indexed keywords

DODECYL 2 O [8 (5' MALONYLZIDOVUDINE)OCTYL]THIOGLYCERO 3 PHOSPHOCHOLINE; INK 20; LAMIVUDINE; NEVIRAPINE; SAQUINAVIR; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MULTIDRUG RESISTANCE; VIROGENESIS; VIRUS ISOLATION; VIRUS PLAQUE; VIRUS RESISTANCE; WILD TYPE;

ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; HIV; HIV INFECTIONS; HUMANS; MALONATES; PHOSPHORYLCHOLINE; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 1542784303     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120028335     Document Type: Article

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