Structure-function study of a chlorotoxin-chimer and its activity on Kv1.3 channels

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 803, Issue 1, 2004, Pages 67-73

  Huys, Isabelle ^a   Waelkens, Etienne ^a   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Chlorotoxin chimer; Kv1.3 channels; Structure function study

Indexed keywords

AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; CLONING;

CHIMERS; VENOM;

TOXIC MATERIALS;

AMINO ACID; CHLOROTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SCORPION VENOM; TOXIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CHIMERA; CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FACTOR XA; KV1.3 POTASSIUM CHANNEL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RECOMBINANT FUSION PROTEINS; SCORPION VENOMS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

LEIURUS QUINQUESTRIATUS; SCORPIONES;

EID: 1542719191     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.11.029     Document Type: Article

References (27)

1. DeBin J.A., Strichartz G.R. Toxicon. 29:1991;1403.
2. DeBin J.A., Maggio J.E., Strichartz G.R. Am. J. Physiol. 264:1993;C361.
3. Tytgat J., Debont T., Rostoll K., Muller G.J., Verdonck F., Daenens P., van der Walt J.J., Possani L.D. FEBS Lett. 441:1998;387.
4. Ullrich N., Gillespie G.Y., Sontheimer H. NeuroReport. 7:1995;343.
5. Ullrich N., Sontheimer H. Am. J. Physiol. 270:1996;C1511.
6. Ullrich N., Sontheimer H. Am. J. Physiol. 273:1997;C1290.
7. Ullrich N., Bordey A., Gillespie G.Y., Sontheimer H. Neuroscience. 83:1998;1161.
8. Soroceanu L., Manning T.J. Jr., Sontheimer H. J. Neurosci. 19:1999;5942.
9. Lippens G., Najib J., Wodak S.J., Tartar A. Biochemistry. 34:1995;13.
10. Bontems F., Roumestand C., Gilquin B., Menez A., Toma F. Science. 254:1991;1521.
11. Tytgat J., Chandy K.G., Garcia M.L., Gutman G.A., Martin-Eauclaire M.F., van der Walt J.J., Possani L.D. Trends Pharmacol. Sci. 20:1999;444.
12. Garcia M.L., Garcia-Calvo M., Hidalgo P., Lee A., MacKinnon R. Biochemistry. 33:1994;6834.
13. Huys I., Dyason K., Waelkens E., Verdonck F., van Zyl J., du Plessis J., Muller G.J., van der Walt J., Clynen E., Schoofs L., Tytgat J. Eur. J. Biochem. 269:2002;1854.
14. Swanson R., Marshall J., Smith J.S., Williams J.B., Boyle M.B., Folander K., Luneau C.J., Antanavage J., Oliva C., Buhrow S.A.et al. Neuron. 4:1990;929.
15. Vita C., Roumestand C., Toma F., Menez A. Proc. Natl. Acad. Sci. U.S.A. 92:1995;6404.
16. Drakopoulou E., Zinn-Justin S., Guenneugues M., Gilqin B., Menez A., Vita C. J. Biol. Chem. 271:1996;11979.
17. Vita C., Drakopoulou E., Vizzavona J., Rochette S., Martin L., Menez A., Roumestand C., Yang Y.S., Ylisastigui L., Benjouad A., Gluckman J.C. Proc. Natl. Acad. Sci. U.S.A. 96:1999;13091.
18. Sabatier J.M., Lecomte C., Mabrouk K., Darbon H., Oughideni R., Canarelli S., Rochat H., Martin-Eauclaire M.F., van Rietschoten J. Biochemistry. 35:1996;10641.
19. Zhu Q., Liang S., Martin L., Gasparini S., Menez A., Vita C. Biochemistry. 41:2002;11488.
20. Calabro V., Sabatier J.M., Blanc E., Lecomte C., Van Rietschoten V., Darbon H. J. Pept. Res. 50:1997;39.
21. Drakopoulou E., Vizzavona J., Neyton J., Aniort V., Bouet F., Virelizier H., Menez A., Vita C. Biochemistry. 37:1998;1292.
22. Flinn J.P., Murphy R., Johns R.B., Kunze W.A., Angus J.A. Int. J. Pept. Protein Res. 45:1995;320.
23. Bonmatin J.M., Bonnat J.L., Gallet X., Vovelle F., Ptak M., Reichhart J.M., Hoffmann J.A., Keppi E., Legrain M., Achstetter T. J. Biomol. NMR. 2:1992;235.
24. Bruix M., Jimenez M.A., Santoro J., Gonzalez C., Colilla F.J., Mendez E., Rico M. Biochemistry. 32:1993;715.
25. Caldwell J.E., Abildgaard F., Dzakula Z., Ming D., Hellekant G., Markley J.L. Nat. Struct. Biol. 5:1998;427.
26. Ceciliani F., Bortolotti F., Menegatti E., Ronchi S., Ascenzi P., Palmieri S. FEBS Lett. 342:1994;221.
27. Huys I., Tytgat J. Eur. J. Neurosci. 17:2003;1786.