Cysteine is the initial site of modification of α-crystallin by kynurenine

Biochemical and Biophysical Research Communications

Volumn 276, Issue 1, 2000, Pages 216-223

  Aquilina, J A ^a   Truscott, R J W ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Ageing; Cataract; Kynurenine; Lens; Protein modification

Indexed keywords

ALPHA CRYSTALLIN; CYSTEINE; KYNURENINE;

AGING; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CATTLE; LENS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN STABILITY;

ANIMALIA; BOS TAURUS;

EID: 0034675384     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3461     Document Type: Article

References (21)

1. Changes in proteins of the human lens in development and aging
2. Dynamic light scattering in the intact rabbit lens. Its relation to protein concentration
3. Short-range order of crystallin proteins accounts for eye lens transparency
4. Expression of recombinant bovine γB-, γC- and γD-crystallins and correlation with native proteins
5. Posttranslational modifications of water soluble human lens crystallins from young adults
6. Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometry
7. Age-related changes in human lens crystallins identified by HPLC and mass spectrometry
8. Stepwise degradations and deamidation of the eye lens protein alpha-crystallin in ageing
9. Oxidation of glycated proteins: Age-dependent accumulation of N(ε)-(carboxymethyl)lysine in lens proteins
10. Truncation of alpha A-crystallin from the human lens
11. Non-tryptophan fluorescence of crystallins from normal and cataractous lenses
12. Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens
13. Human lens coloration and aging. Evidence for crystallin modification by the major ultraviolet filter, 3-hydroxykynurenine o-β-D-glucoside
14. Non-oxidative modification of lens crystallins by kynurenine: A novel post-translational protein modification with possible relevance to ageing and cataract
15. UV filter compounds in human lenses: The origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanol acid O-beta-D-glucoside
16. Protein bound kynurenine in human lenses
17. Synthesis of human ultraviolet filter compounds: O-beta-D-Glucopyranosides of 3-hydroxykynurenine and 2-amino-3-hydroxy-gamma-oxobenzenebutanoic acid
18. Elucidation of the primary structures of proteins by mass spectrometry
19. Direct measurement of pH in the rat lens by ion-sensitive microelectrodes