Polymorphisms in the Vitamin D Receptor Gene, Ultraviolet Radiation, and Susceptibility to Prostate Cancer

Environmental and Molecular Mutagenesis

Volumn 43, Issue 2, 2004, Pages 121-127

  Bodiwala, Dhaval ^a,b   Luscombe, Christopher J ^a   French, Michael E ^a   Liu, Samson ^a   Saxby, Mark F ^a   Jones, Peter W ^c   Fryer, Anthony A ^b   Strange, Richard C ^b  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b KEELE UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

Author keywords

Prostate cancer; Prostate cancer susceptibility; Ultraviolet radiation; Vitamin D receptor

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; VITAMIN D; VITAMIN D RECEPTOR;

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSTATE CANCER; ULTRAVIOLET RADIATION;

DISEASE SUSCEPTIBILITY; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RECEPTORS, CALCITRIOL; RISK FACTORS; ULTRAVIOLET RAYS;

EID: 1542618519     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20000     Document Type: Article

References (34)

1. Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P. 2001. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels. Cancer Causes Control 11:847-852.
2. Arai H, Miyamoto KI, Yoshida M, Yamamoto H, Taketani Y, Morita K, Kubota M, Yoshida S, Ikeda M, Watabe F, Kanemasa Y, Takeda E. 2001. The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene. J Bone Miner Res 16:1256-1264.
3. Blazer DG, Umbach DM, Bostick RM, Taylor JA. 2000. Vitamin D receptor polymorphisms and prostate cancer. Mol Carcinog 27:18-23.
4. Bodiwala D, Luscombe CJ, Liu S, Saxby M, French M, Jones PW, Fryer AA, Strange RC. 2003a Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sunlight. Cancer Lett 192:145-149.
5. Bodiwala D, Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Ramachandran S, Fryer AA, Strange RC. 2003b. Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type. Carcinogenesis 24:711-717.
6. Chen TC, Holick MF. 2003. Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 14:423-430.
7. Colhoun HM, McKeigue PM, Smith GD. 2003. Problems of reporting genetic associations with complex outcomes. Lancet 361:865-872.
8. Correa-Cerro L, Berthon P, Haussler J, Bochum S, Drelon E, Mangin P, Fournier G, Paiss T, Cussenot O, Vogel W. 1999. Vitamin D receptor polymorphisms as markers in prostate cancer. Hum Genet 105:281-287.
9. Crofts LA, Hancock MS, Morrison NA, Eisman JA. 1998. Multiple promoters direct the tissue-specific expression of novel N-terminal variant vitamin D receptor gene transcripts. Proc Natl Acad Sci USA 95:10529-10534.
10. Fijneman RJ, Jansen RC, van der Valk MA, Demant P. 1998. High frequency of interactions between lung cancer susceptibility genes in the mouse: mapping of Sluc5 to Sluc14. Cancer Res 58:4794-4798.
11. Feldman D, Zhao X-Y, Krishnan AV. 2000. Vitamin D and prostate cancer. Endocrinology 141:5-9.
12. Frankel WN, Schork NJ. 1996. Who's afraid of epistasis? Nat Genet 14:371-373.
13. Grant WB. 2002. An estimate of premature cancer mortality in the United States due to inadequate doses of solar ultraviolet-B radiation, a source of vitamin D. Cancer 94:1867-1875.
14. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D. 1996. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res 11:1850-1855.
15. Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D. 1998. The vitamin D receptor gene start codon polymorphism: a functional analysis of Fok1 variants. J Bone Miner Res 13:1691-1699.
16. Gsur A, Madersbacher S, Haidinger G, Schatzl G, Marberger M, Vutuc C, Micksche M. 2002. Vitamin D receptor gene polymorphism and prostate cancer risk. Prostate 51:30-34.
17. Hanchette CL, Schwartz GG. 1992. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 70:2861-2869.
18. Holtgrewe HL. 2001. Lower urinary tract symptoms and benign prostatic hyperplasia. In: Syrigos KN, editor. Prostate cancer: biology, diagnosis, and management. New York: Oxford University Press. p 35-49.
19. Hutchinson PE, Osbourne J, Lear JT, Smith AG, Bowers PW, Morris PN, Jones PW, York C, Strange RC, Fryer AA. 2000. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. Clin Cancer Res 6:498-504.
20. Ingles SA, Ross RK, Yu MC, Irvine RA, La Pera G, Haile RW, Coetzee GA. 1997. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst 89:166-170.
21. Kibel AS, Isaacs SD, Isaacs WB, Bova GS. 1998. Vitamin D receptor polymorphisms and lethal prostate cancer. J Urol 160:1405-1409.
22. Krill D, DeFlavia P, Dhir R, Luo J, Becich MJ, Lehman E, Getzenberg RH. 2001. Expression patterns of vitamin D receptor in human prostate. J Cell Biochem 82:566-572.
23. Luscombe CJ, Fryer AA, French ME, Liu S, Saxby MF, Jones PW, Strange RC. 2001a. Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. Lancet 358:641-642.
24. Luscombe CJ, French ME, Liu S, Saxby MF, Jones PW, Fryer AA, Strange RC. 2001b. Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. Br J Cancer 85:1504-1509.
25. Ma J, Stampfer MJ, Gann PH, Hough HL, Giovannucci E, Kelsey KT, Hennekens CH, Hunter DJ. 1998. Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians. Cancer Epidemiol Biomarkers Prev 7:385-390.
26. Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, Lopes C. 2002. The role of vitamin D receptor gene polymorphisms in the susceptibility to prostate cancer of a southern European population. J Hum Genet 47:413-418.
27. Rosenberger WF. 1996. dealing with multiplicities in pharmaco-epidemiologic studies. Pharmacoepidemiol Drug Safety 5:95-100.
28. Schatzl G, Gsur A, Bernhofer G, Haidinger G, Hinteregger S, Vutuc C, Haitel A, Micksche M, Marberger M, Madersbacher S. 2001. Association of vitamin D receptor and 17 hydroxylase gene polymorphisms with benign prostatic hyperplasia and benign prostatic enlargement. Urology 57:567-572.
29. Studzinski GP, Moore DC. 1995. Sunlight - can it prevent as well as cause cancer? Cancer Res 55:4014-4022.
30. Taylor JA, Hirvonen A, Watson M, Pittman G, Mohler JL, Bell DA. 1996. Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Res 56:4108-4110.
31. Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HTL, Haussler CA, Galligan MA, Thatcher ML, Dominguez CE, Haussler MR. 2001. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol 177:145-159.
32. Xu Y, Shibata A, McNeal JE, Stanley TA, Feldman D, Peehl DM. 2003. Vitamin D receptor start codon polymorphism (Fok1) and prostate cancer progression. Cancer Epidemiol Biomarkers Prog 12:23-27.
33. Young JM, Muscatello DJ, Ward JE. 2000. Are men with lower urinary tract symptoms at increased risk of prostate cancer? A systematic review and critique of the available evidence. Br J Urol Int 85:1037-1048.
34. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG. 2001. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 53:79-91.