Cloning and expression of 5, 10-Methylenetetrahydrofolate reductase (MTHFR) gene

Science in China, Series C: Life Sciences

Volumn 41, Issue 6, 1998, Pages 636-643

  Chen, Guanghui ^a   Zhang, Chenhui ^a   Zhang, Xiaoyu ^a   Zhu, Yanqing ^a   Tang, Jian ^a   Meng, Zhaoheng ^a   Li, Zhu ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cloning and expression; MTHFR

Indexed keywords

EID: 1542526985     PISSN: 10069305     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02882906     Document Type: Article

References (16)

1. Jacques, P. F., Bostom, A. G., Williams, R. R. et al., Relation between folate status, a common mutation in methyleenete-trahydrofolate reductase, and plasma homocysteine concentrations, Circulation, 1996, 93: 7.
2. Refsum, H., Ueland, P. M., Clinical significance of pharmacological modulation of homocysteine metabolism, Trends-Pharmacol Sci., 1990, 11: 411.
3. Czeizel, A. E., Congenital abnormalities are preventable, Epidemiology, 1995, 6: 205.
4. Motulsky, A. G., Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid, Am. J. Hum. Genet., 1996, 58: 17.
5. Drown, D. J., Homocysteine: an independent risk factor associated with coronary disease and other arterial occlusive diseases in adults, Prog. Cardiovascular Disease, 1995, 10: 37.
6. Zhu Huiping, Chen Guanghui, Li Zhu, Molecular pathogenesis of neural tube of deformity, Journal of Improving Birth Outcome and Child Development of China, 1996, 3: 185.
7. Kluijtman, L. A., Lambert, P., Godfied, H. J. et al., Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease, Am. J. Hum. Genet., 1996, 58: 35.
8. Goyette, P., Sumner, J. S., Milos, R. et al., Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification, Nature Genet., 1994, 7: 196.
9. Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning: A Laboratory Mannual, 2nd ed., New York: Cold Spring Harbor Laboratory Press, 1989.
10. Zhang Chenhui, Li Qianhong, Zhang Jifeng et al., Semiquantitative detection and application about the expression of nitric oxide synthase gene, Acta Physiologica Sinica, 1994, 46: 347.
11. Roll, P. H., Friggi, A., Barlatier, A. et al., Hyperhomocysteinemia-induced vascular damage in the minipig: Captopril-hydrochlorothiazide combination prevents elastic alterations, Circulation, 1995, 91: 1161.
12. Matthias, D., Becker, C. H., Riezler, R. et al., Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine, Atherosclerosis, 1996, 122: 201.
13. Frosst, P., Blom, H. J., Milos, R. et al., A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, Nature Genet., 1995, 10: 111.
14. Lucock, M. D., Wild, J., Schorah, C. J. et al., The methylfolate axis in neural tube defects: in vitro characterization of an clinical investigation, Biochem. Med. and Metab. Biol., 1994, 52: 101.
15. Meng Zhaoheng, Li Zhu, Chen Guanghui et al., Preparation and application of antibodies against 5, 10-methylenete-trahydrofolate reductase (MTHFR), Chinese Biochemical Journal, 1998, 14(5): 59.
16. Ross, R., The pathogenesis of atherosclerosis: a perspective for the 1990s, Nature, 1993, 362: 801.